Patents by Inventor Daniel A. Harki

Daniel A. Harki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE BRD4-DEGRADER MOLECULES
    Publication number: 20240051938
    Abstract: The invention provides a compound of formula (I): or a salt thereof wherein B, L, and X have any of the values defined in the specification, as well as compositions comprising a compound of formula (I) or a salt thereof. The compounds selectively degrade BRD4, and are useful as to treat cancer and inflammatory conditions.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 15, 2024
    Applicant: Regents of the University of Minnesota
    Inventors: Huarui Cui, Anand Divakaran, Daniel A. Harki, William C. K. Pomerantz
  • COMPOUNDS THAT DEGRADE KINASES AND USES THEREOF
    Publication number: 20220233702
    Abstract: The disclosure is directed to compounds of the Formula (I) or (II): A—L1—B, A?—L1—B, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein A is an Aurora A ligand, A? is a CDK4/6 ligand; B is an E3 ligase ligand; and L1 is a linker, as well as pharmaceutical compositions comprising such compounds, and methods for treating cancer using such compounds.
    Type: Application
    Filed: June 3, 2020
    Publication date: July 28, 2022
    Inventors: Daniel A. Harki, Jian Tang, Ramkumar Moorthy, Rommie E. Amaro, Ozlem Demir
  • Inhibitors for steroid response elements and RNA polymerase II and related methods
    Patent number: 9630950
    Abstract: The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The present invention also relates to polyamides capable of modulating the activity of RNA polymerase II and p53. The invention also relates to methods to treat diseases related to ARE-, GRE- and ERE-mediated gene regulation and to RNA polymerase II and p53 activity.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 25, 2017
    Assignee: California Institute of Technology
    Inventors: Peter B. Dervan, Nicholas G. Nickols, Claire S. Jacobs, Michelle E. Farkas, Daniel A. Harki
  • METHODS AND MATERIALS FOR ASSESSING ENZYME-NUCLEIC ACID COMPLEXES
    Publication number: 20170003289
    Abstract: Materials and methods for assessing the presence, absence, and/or amount of an enzyme-nucleic acid complex in a sample are provided. Also provided are materials and methods for making and using an anti-enzyme-nucleic acid covalent complex antibody.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Daniel A. Harki, Scott H. Kaufmann, Angela Lyn Perkins-Harki
  • CYTOSINE DEAMINASE MODULATORS FOR ENHANCEMENT OF DNA TRANSFECTION
    Publication number: 20140275224
    Abstract: Compounds and methods are provided for enhancing or boosting the transfection rate or efficiency of mammalian cells by foreign DNA, such as bacterial plasmid DNA. Compounds, including natural products and inventive synthetic compounds can increase the effectiveness of uptake and incorporation of foreign DNA by mammalian cells, such as human cells, by suppression of DNA cytosine deamination, which is believed to be a mechanism by which these cells eliminate foreign DNA. Inhibition of the cytosine deaminase enzymes by compounds as described herein serves to provide more effective transfection of eukaryotic cells by plasmids including engineered gene sequences. Transfection can be used to study cellular processes, or to cure genetic diseases in human patients. The inventive materials and methods increase the efficiency and effectiveness of such transfection techniques.
    Type: Application
    Filed: November 3, 2011
    Publication date: September 18, 2014
    Applicant: Regents of the University of Minnesota
    Inventors: Reuben S. Harris, Daniel A. Harki, Angela L. Perkins-Harki, Michael A. Carpenter, Ming Li
  • Polyamides with tail structures capable of binding DNA
    Patent number: 7935530
    Abstract: The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: May 3, 2011
    Assignee: California Institute of Technology
    Inventors: Peter B. Dervan, Claire S. Jacobs, Nicholas G. Nickols, Daniel A. Harki
  • Polyamides with tail structures
    Publication number: 20080269138
    Abstract: The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research.
    Type: Application
    Filed: November 28, 2007
    Publication date: October 30, 2008
    Inventors: Peter B. Dervan, Claire S. Jacobs, Nicholas G. Nickols, Daniel A. Harki