Patents by Inventor Daniel A. Jacobson

Daniel A. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial quantitative trait-locus mapping
    Patent number: 12362039
    Abstract: This disclosure provides methods for performing quantitative-trait loci (QTL) analysis in bacteria. The methods of the instant disclosure utilize multiple rounds of protoplast fusion-induced genomic recombination to break genetic linkages in bacterial genomes. The methods of the instant disclosure allow determining which genetic elements (QTL) are associated with phenotypic al features.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: July 15, 2025
    Assignee: UT-Battelle, LLC
    Inventors: Joshua K. Michener, Daniel A. Jacobson, Delyana Vasileva, Jared Streich
  • METHODS FOR CONTROLLING CELL WALL BIOSYNTHESIS AND GENETICALLY MODIFIED PLANTS
    Publication number: 20240076686
    Abstract: The present disclosure provides methods of producing plants with preferred levels of cell wall biosynthesis; and uses of such plants. The inventors have identified that the GFR9, CCoAOMT and MYB41 genes are major regulators of the cell wall biosynthesis pathway. Plants with modulated cell wall biosynthesis, based on modulation of the expression or activity of the GFR9, CCoAOMT and MYB41 genes, have divergent uses including pulp and paper production, and bioproduct production.
    Type: Application
    Filed: June 15, 2023
    Publication date: March 7, 2024
    Inventors: Timothy J. Tschaplinski, Daniel A. Jacobson, David Kainer, Deborah A. Weighill, Anna K. Furches
  • Microorganisms engineered for muconate production
    Patent number: 11781107
    Abstract: Disclosed herein are the genetically modified Pseudomonas with improved tolerance to hydroxycinnamic acids.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: October 10, 2023
    Assignees: Alliance for Sustainable Energy, LLC, UT-Battelle, LLC
    Inventors: Gregg Tyler Beckham, Christopher W. Johnson, Allison Jean Zimont Werner, Davinia Salvachúa Rodríguez, Daniel A. Jacobson, Erica Teixeira Prates, Elsayed Tharwat Tolba Mohamed, Adam Michael Feist
  • Methods for controlling cell wall biosynthesis and genetically modified plants
    Patent number: 11725215
    Abstract: The present disclosure provides methods of producing plants with preferred levels of cell wall biosynthesis; and uses of such plants. The inventors have identified that the GFR9, CCoAOMT and MYB41 genes are major regulators of the cell wall biosynthesis pathway. Plants with modulated cell wall biosynthesis, based on modulation of the expression or activity of the GFR9, CCoAOMT and MYB41 genes, have divergent uses including pulp and paper production, and bioproduct production.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: August 15, 2023
    Assignees: UT-Battelle, LLC, University of Tennessee Research Foundation
    Inventors: Timothy J. Tschaplinski, Daniel A. Jacobson, David Kainer, Deborah A. Weighill, Anna K. Furches
  • SPECIFIC STRUCTURAL VARIANTS DISCOVERED WITH NON-MENDELIAN INHERITANCE
    Publication number: 20220101945
    Abstract: The present disclosure is directed to methods of identifying structural variants (SVs) from single nucleotide polymorphisms (SNPs) that demonstrate non-Mendelian inheritance pattern (NMI) and finding the biological relevance of the SVs through machine learning. Also disclosed are processors programmed to identify biologically-relevant SVs and computer-readable storage devices comprising instructions to identify biologically-relevant SVs.
    Type: Application
    Filed: September 28, 2021
    Publication date: March 31, 2022
    Inventors: Michael R. Garvin, Daniel A. Jacobson, David Kainer, Erica Teixeira Prates
  • METHODS OF TREATING COVID-19 PATHOGENESIS
    Publication number: 20220008380
    Abstract: This disclosure provides methods for treating a SARS-CoV-2 infection in a subject comprising administering to the subject an effective amount of an inhibitor of COVID-induced RAS imbalance, that downregulates, for example, the Bradykinin system, the Renin-Angiotensin system, the hyaluronan synthesis pathway, or the fibrinogenesis pathway.
    Type: Application
    Filed: July 7, 2021
    Publication date: January 13, 2022
    Inventors: Daniel A. Jacobson, Erica Teixeira Prates, John I. Miller, Michael R. Garvin
  • MICROORGANISMS ENGINEERED FOR MUCONATE PRODUCTION
    Publication number: 20210261911
    Abstract: Disclosed herein are the genetically modified Pseudomonas with improved tolerance to hydroxycinnamic acids.
    Type: Application
    Filed: February 24, 2021
    Publication date: August 26, 2021
    Inventors: Gregg Tyler BECKHAM, Christopher W. JOHNSON, Allison Jean ZIMONT WERNER, Davinia SALVACHÚA RODRÍGUEZ, Daniel A. JACOBSON, Erika TEIXEIRA PRATES, Elsayed Tharwat Tolba MOHAMED, Adam Michael FEIST
  • METHODS FOR CONTROLLING CELL WALL BIOSYNTHESIS AND GENETICALLY MODIFIED PLANTS
    Publication number: 20200102571
    Abstract: The present disclosure provides methods of producing plants with preferred levels of cell wall biosynthesis; and uses of such plants. The inventors have identified that the GFR9, CCoAOMT and MYB41 genes are major regulators of the cell wall biosynthesis pathway. Plants with modulated cell wall biosynthesis, based on modulation of the expression or activity of the GFR9, CCoAOMT and MYB41 genes, have divergent uses including pulp and paper production, and bioproduct production.
    Type: Application
    Filed: October 2, 2019
    Publication date: April 2, 2020
    Inventors: Timothy J. Tschaplinski, Daniel A. Jacobson, David Kainer, Deborah A. Weighill, Anna K. Furches