Abstract: In some aspects, the invention relates to methods of treating conditions associated with sleep disorders, comprising administering an agent that modulates the activity of a neuropeptide receptor or a neuropeptide receptor ligand. In some aspects, the invention relates to methods of screening agents that modulate the activity of a neuropeptide receptor in an organism, optionally using cells or organisms comprising a genetic modification that affects a neuropeptide signaling pathway. In some aspects, the invention relates to methods of characterizing a condition associated with a sleep disorder comprising sequencing a nucleic acid encoding either a neuropeptide receptor or a neuropeptide receptor ligand and comparing the sequence with a reference sequence.

Abstract: An auxiliary shirt cuff which can be applied to virtually any type of shirt. It does not require any modification to the shirt. When applied, the cuff gives the appearance of a high-quality french cuff shirt. It can be applied to a shirt already having a french cuff, or to one having a conventional button cuff. Different fabrics and colors can be employed to make the cuff, thereby creating a pleasing and fashionable contrast with the fabric and color of the shirt to which the cuff is applied.

Abstract: A vehicle has a plurality of studs secured to its frame at predetermined locations. At least one groups of wires used to electrically interconnect electrical components of the vehicle are taped together and routed along the vehicle frame. Clips, each having a beam including a beam opening with a gripping device in the opening, are forced down onto the studs to secure the clips onto the studs. At least one wire of the group of wires is secured to the clip and therefore to the stud. The other wires of the group of wires, which are taped to the at least one wire, are according secured to the stud. A method of securing groups of wires to the vehicle frame incorporates use of the clips.