Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.

Abstract: The disclosed methods, systems, and kits provide the ability to deliver entire clean sheet designs from concept to first hot fire in under six weeks with instant specific impulses above 330 seconds in some of our engines. In examples, thrusters can be delivered that are at less than half of the mass budget allowable for them and they can be delivered in weeks.

Abstract: The present invention is directed to a cryogenic cooler that may include a cold finger coupled to a cooling source, an insulating vessel having an inner wall, an outer wall and an interior area formed within the inner wall, where the cold finger may be positioned at least partially within the interior area. The cryogenic cooler may also have a fitting positioned on the outer wall and configured for coupling to a gas source, and a passageway formed between the coupling and the inner wall and configured to allow the transfer of a gas from the gas source to the interior area. The cryogenic cooler may also have an opening is formed in the interior area so as to allow the transfer of the gas around the cold finger and out of the interior area.

Abstract: An illustrative embodiment of the invention relates to a mechanical shock suppressor sensitive to velocity or acceleration of a predetermined level capable of restraining relative movement associated therewith of structures supported by the suppressor. The suppressor comprises frictional engaging portions having compressive means disposed thereon which increase the frictional restraining force only during movements of a predetermined level.