Abstract: Compounds of formula (I) wherein RF1, RF2, Z, R1, R2, Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain.

Abstract: Compounds of general formula: wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Compounds of general formula (I) wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R1, R2, RF1, RF2 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared.

Abstract: Compounds of formula (I) wherein RF1, RF2, Z, R1, R2, Ar, X and Y are as dcfined in thc specification as wcll as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain.

Abstract: Compounds of Formulae (IA), (IB) or pharmaceutically acceptable salts thereof; wherein Het, X1, R1, R2, R3, R3a and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, R4, n and Ar are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Devices and method for reproducing sound and transmitting a first sound signal and a second sound signal includes a producer having a means for coding the second sound signal, and a means for combining the first sound signal and the coded second sound signal into a composite sound signal that can be reproduced by reproducing means in such a manner that the second sound signal is inaudible to the human ear. A transmitter is provided including a first reproducing means, and a receiver having a means for receiving the composite signal, a means for extracting the coded second sound signal from the composite signal, a decoding means, and a second reproducing means.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: A head protection system comprises a helmet shell, a visor mounting for pivotally mounting a visor to the shell to enable the visor to be moved between raised and lowered positions, and a retainer for releasably retaining the visor to the helmet. The system includes a visor adapted for mounting on the shell which comprises a substrate of transparent thermoplastic material and a backing substrate comprising a plurality of layers of high performance, ballistic resistant material. The system may further include a second visor which can be releasably connected to the shell using the same visor mounting and which may have a different construction and primary function.

Abstract: Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R1, R2, RF1, RF2 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: An artificial seedbed used in growing vegetation. The artificial seedbed comprises a base layer formed of a biodegradable product having a porosity and wet density that permit a root of the desired vegetation to penetrate the base layer and establish the vegetation for growing. The artificial seedbed also comprises an intermediate layer comprising a plurality of seeds for use in growing the desired vegetation. A cover layer cooperates with the base layer to form an envelope about the intermediate layer. The cover layer can be coextensive with the base layer and secured to the base layer by a bonding agent. The cover layer is formed of the same or different biodegradable product as the base layer. The material used in the cover layer permits the sprouting vegetation to penetrate it during the growing process.

Abstract: Compounds of general formula (1) wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: A water quality detection system for distributed water supply network. The system, 1, comprises a multiplicity of detectors, 5, wherein each detector of the detectors is capable of monitoring at least one attribute of water and providing a signal related to the attribute. A controller, 7, is provided which is capable of receiving each signal and comparing the signal to a control signal for the attribute. A response mechanism, 9, is responsive to the controller and activated when at least one signal matches the control signal. An access gate, 10, limits access to at least one of the detector, the controller or the response mechanism. An access key, 13, is provided for comparing a user attribute with a stored attribute wherein when the user attribute matches the stored attribute access is provided into the access gate.

Abstract: A valve lock has a body and a moveable jaw for releasably gripping a lever handle of the valve against the body. The jaw has a threaded shaft that extends through a hole in the body, and a locking cleat is slidable on the threaded shaft. An arm is attached to the shaft between the body and the locking cleat, and is rotatable about the shaft to abut either the valve or a pipe connected to the valve. A hand wheel is threaded onto the shaft and can be tightened against the locking cleat which then forces the arm against the body to inhibit rotation of the arm about the shaft. The locking cleat has an aperture for receiving the shackle of a padlock, and the hand wheel has a plurality of notches in an exterior surface with one of the notches receiving the shackle to restrict movement of the wheel along the shaft.

Abstract: A tooth flossing device for making the task of flossing teeth easier, neater, and more effective. A handle, designed for being gripped by a hand of a user, carries a removable, replaceable cartridge attached to one end. This cartridge contains a length of dental floss stretched between two pole pieces which are just far enough apart to pass a tooth between them. A user inserts the cartridge end of the flosser into his mouth, pressing the length of floss between two adjacent teeth, repeating the action until the spaces between all teeth have been cleaned. A used cartridge can be quickly and easily removed from the handle and replaced by a new one by pressing a detent and sliding the old cartridge from engagement with the handle. When the fresh cartridge is inserted, the detent automatically locks it into position.