Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: The disclosure generally relates to ultra high molecular weight poly(ethylene) (“UHMWPE”) tubes with an average wall thickness of 0.2 mm or less; a tensile stress at break greater than 40 MPa; and a storage modulus of greater than 500 MPa at 23° C. The disclosure further relates to preparing and using such tubes and to constructions (e.g., catheter constructions) and components thereof including such tubes.

Abstract: A method for providing Cheon-resistance security for a static elliptic curve Diffie-Hellman cryptosystem (ECDH), the method including providing a system for message communication between a pair of correspondents, a message being exchanged in accordance with ECDH instructions executable on computer processors of the respective correspondents, the ECDH instructions using a curve selected from a plurality of curves, the selecting including choosing a range of curves; selecting, from the range of curves, curves matching a threshold efficiency; excluding, within the selected curves, curves which may include intentional vulnerabilities; and electing, from non-excluded selected curves, a curve with Cheon resistance, the electing comprising a curve from an additive group of order q, wherein q is prime, such that q?1=cr and q+1=ds, where r and s are primes and c and d are integer Cheon cofactors of the group, such that cd?48.

Abstract: An elliptic curve random number generator avoids escrow keys by choosing a point Q on the elliptic curve as verifiably random. An arbitrary string is chosen and a hash of that string computed. The hash is then converted to a field element of the desired field, the field element regarded as the x-coordinate of a point Q on the elliptic curve and the x-coordinate is tested for validity on the desired elliptic curve. If valid, the x-coordinate is decompressed to the point Q, wherein the choice of which is the two points is also derived from the hash value. Intentional use of escrow keys can provide for back up functionality. The relationship between P and Q is used as an escrow key and stored by for a security domain. The administrator logs the output of the generator to reconstruct the random number with the escrow key.

Abstract: The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.

Abstract: A method for verification at a computing device of a signed message received from a first party over a public communications channel, the method including extracting a message digest “a” belonging to a semigroup from the signed message; obtaining a public key [c,e] for the first party, including a fixed value checker “c” and an endpoint “e”, checker “c” and endpoint “e” belonging to the semigroup and the endpoint comprising a multiplication of a private key “b” for the first party and the checker “c”, multiplying the message digest “a” and the endpoint “e” to create an endmatter “ae”; extracting a signature “d” from the signed message, the signature “d” belonging to the semigroup and being a multiplication of message digest “a” and private key “b”; multiplying the signature “d” and the checker “c” to create a signcheck “dc”; and verifying that the endmatter “ae” matches the signcheck “dc”.

Abstract: A fluid ejector for ejecting discrete volumes of ejectant includes a body with opposing first and second surfaces. One or more nozzles are defined as conduits extending through the body between the surfaces to connect first and second orifices at the first and second surfaces respectively. The fluid ejector further includes a gas supply means having a gas outlet and an ejectant supply means. The ejectant supply means supplies the ejectant to the nozzles at a pressure above ambient via their supply orifices. The supply orifice is defined in a conduit's side or is the second orifice. Relative movement of the gas supply means and body exposes first orifices to the gas outlet allowing the gas supply means to supply gas at a pressure above ambient, wherein a pressure difference thereby created between the first and second orifices causes ejection of the ejectant from the nozzles through the second orifices.

Abstract: A computing system retrieves ball-by-ball data for a plurality of sporting events. The computing system generates a trained neural network based on ball-by-ball data supplemented with ball-by-ball data with ball-by-ball match context features and personalized embeddings based on a batsman and a bowler for each delivery. The computing system receives a target batsman and a target bowler for a pitch to be delivered in a target event. The computing system identifies target ball-by-ball data for a window of pitches preceding the to be delivered pitch. The computing system retrieves historical ball-by-ball data for each of the target batsman and the target bowler. The computing system generates personalized embeddings for both the target batsman and the target bowler based on the historical ball-by-ball data. The computing system predicts a shot type for the pitch to be delivered based on the target ball-by-ball data and the personalized embeddings.

Abstract: The present invention provides a crystalline form of (2R,3S)-N-((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinimide, represented by the structure of Compound (1), wherein the crystalline form comprises N-2 crystalline form, IPA2-1 crystalline form, M3-1 crystalline form, P4 crystalline form, P5 crystalline form, P6 crystalline form, or any combination thereof. The present invention also provides processes for the preparation of a the crystalline form, and pharmaceutical compositions comprising one or more of the crystalline forms.

Abstract: A segmentation firewall executing on a host enforces a segmentation policy. In a co-existence mode, the segmentation firewall operates in co-existence with a system firewall that enforces a security policy. The segmentation firewall is configured to either drop packets that do not match any permissive rule or pass packets that match a permissive rule to the system firewall to enable the system firewall to determine whether to drop or accept the passed packets. To enable efficient operation of the segmentation firewall when operating in co-existence with the system firewall, the segmentation firewall may include a plurality of rule chains and may be configured to exit a chain and bypass remaining rule chains upon an input packet matching a permissive rule of the segmentation policy.

Abstract: A method for key agreement between a first party and a second party over a public communications channel, the method including selecting, by the first party, from a semigroup, a first value “a”; multiplying the first value “a” by a second value “b” to create a third value “d”, the second value “b” being selected from the semigroup; sending the third value “d” to the second party; receiving, from the second party, a fourth value “e”, the fourth value comprising the second value “b” multiplied by a fifth value “c” selected by the second party from the semigroup; and creating a shared secret by multiplying the first value “a” with the fourth value “e”, wherein the shared secret matches the third value “d” multiplied by the fifth value “c”.

Abstract: A system can validate multiple nonvolatile random-access memory (NVRAM) devices in parallel. The system can concurrently write a first data to a first volatile memory of a first NVRAM device and a second NVRAM device. The system can modify a first electrical power source that provides an electrical power output that is received by the first NVRAM device and is received by the second NVRAM device to modify a voltage of the electrical power from a first value to a second value to initiate the first NVRAM device and the second NVRAM device to respectively perform a vault. The system can reset the first electrical power source, causing the first NVRAM device and the second NVRAM device to reset. The system can verify whether the first NVRAM device and the second NVRAM device respectively store the first data in volatile memory subsequent to performing the resetting.

Abstract: The present disclosure includes methods of using a sacrificial, protective head overcoat during the manufacture of sliders. In some embodiments, the final trailing edge topography of the transducer devices is formed before applying the sacrificial, protective head overcoat. In some embodiments, the final trailing edge topography of the transducer devices is formed after removing the sacrificial, protective head overcoat.

Abstract: A segmentation firewall executing on a host enforces a segmentation policy. In a co-existence mode, the segmentation firewall operates in co-existence with a system firewall that enforces a security policy. The segmentation firewall is configured to either drop packets that do not match any permissive rule or pass packets that match a permissive rule to the system firewall to enable the system firewall to determine whether to drop or accept the passed packets. To enable efficient operation of the segmentation firewall when operating in co-existence with the system firewall, the segmentation firewall may include a plurality of rule chains and may be configured to exit a chain and bypass remaining rule chains upon an input packet matching a permissive rule of the segmentation policy.

Abstract: A portable railroad spike remover comprises a claw assembly extractor that is shaped to engage and secure a railroad spike previously installed into a rail tie. The claw assembly extractor may include a pair of jaw members that are pivotally connected to each other by a pivoting pin and a rotating pin. Each jaw member may include a lower end configured to contact and secure a railroad spike and a pair of upper members interlocked with each other and pivotally connected to the clevis fastener with the rotating pin. When the drive shaft is rotated, the claw assembly extractor and the mounting flange may move inside the main housing in a vertical direction to extract the railroad spike from the rail tie.

Abstract: Disclosed is crystalline Form B of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl) amino)-N-(methyl-d3)pyridazine-3-carboxamide. Form B is the HCl salt of a neat crystalline form. Characterization data for Form B are disclosed.

Abstract: A computing system retrieves ball-by-ball data for a plurality of sporting events. The computing system generates a trained neural network based on ball-by-ball data supplemented with ball-by-ball data with ball-by-ball match context features and personalized embeddings based on a batsman and a bowler for each delivery. The computing system receives a target batsman and a target bowler for a pitch to be delivered in a target event. The computing system identifies target ball-by-ball data for a window of pitches preceding the to be delivered pitch. The computing system retrieves historical ball-by-ball data for each of the target batsman and the target bowler. The computing system generates personalized embeddings for both the target batsman and the target bowler based on the historical ball-by-ball data. The computing system predicts a shot type for the pitch to be delivered based on the target ball-by-ball data and the personalized embeddings.