Abstract: A bone material dispensing system is provided. The bone material dispensing system comprises a funnel having a proximal portion, the proximal portion comprising a top end and a bottom end, the top end opposite the bottom end, the top end comprising a surface having a protrusion configured to receive a locking member of a bone material dispensing device and the bottom end comprising a connector configured to secure the funnel to the bone material dispensing device. A bone material dispensing system comprises a pusher and a holder is provided. A method of dispensing bone material with the bone material dispensing system is also provided.

Abstract: A bone implant for enclosing bone material is provided. The bone implant comprises a covering, which can be a biodegradable mesh. The covering is configured to be rolled into a diameter to at least partially enclose the bone material within the covering. In some embodiments, the covering includes a body portion and a closure portion adjacent to the body portion. The closure portion is configured to hold the covering in a rolled configuration to a predetermined diameter to at least partially enclose the bone material. A kit and a method of using the bone implant are also provided.

Abstract: A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having one or more pores, an inner surface and an outer surface opposing the inner surface, the inner surface configured to receive a bone material when the inner surface of the mesh is in an open configuration; and a plurality of projections disposed on or in at least a portion of the inner surface of the mesh, the outer surface of the mesh or both the inner surface and outer surface of the mesh.

Abstract: A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis, the proximal end having a first opening and the distal end comprising a frame having a front wall, a back wall, and an air gap, the back wall having a back opening and the front wall having a second opening such that the first opening, the back opening and the second opening are configured to slidably receive at least a portion of a plunger, the front wall comprising a generally flat contact surface configured to engage a funnel; and a locking member pivotably connected to an upper surface of the housing and extending adjacent to the upper surface of the housing, the locking member comprising a locking surface extending adjacent to the distal end of the housing, the locking member being movable in a locking position to lock the portion of the funnel with the housing.

Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

Abstract: A bone implant holding and shaping tray is provided. The tray includes a first segment having a distal end and a first surface sized to hold and shape at least a portion of the bone implant with bone material. The tray includes a second segment having a second surface sized to hold and shape at least a portion of the bone implant with bone material, the second segment having a proximal end configured to be coupled to the distal end of the first segment so as to extend the first surface to hold and shape the bone implant. Methods of making and using the bone implant holding and shaping tray are also provided.

Abstract: A bone implant for enclosing bone material is provided. The bone implant comprises a covering, which can be a biodegradable mesh. The covering is configured to be rolled into a diameter to at least partially enclose the bone material within the covering. In some embodiments, the covering also includes a closure member, the closure member configured to hold the covering in a rolled configuration to a predetermined diameter to at least partially enclose the bone material. A kit and a method of using the bone implant are also provided.

Abstract: A method according to one embodiment includes: determining a volume of a harvested autograft, the determining including: receiving an image depicting an anatomical element, the image segmented into a plurality of voxels with each voxel of the plurality of voxels labeled with either a first bone volume label representing a first volume type or a second bone volume label representing a second volume type; and summing a first set of voxel values labeled as having the first volume type and through which an operative portion of a navigated tool passes to determine the volume of the harvested autograft; and determining a total volume of a bone graft for a surgical task, the determining including: identifying a portion of a patient eligible for the bone graft; and summing a second set of voxel values associated with the portion of the patient to determine the total volume of the bone graft.

Abstract: A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis, the proximal end having a first opening and the distal end comprising a frame having a front wall, a back wall, and an air gap, the back wall having a back opening and the front wall having a second opening such that the first opening, the back opening and the second opening are configured to slidably receive at least a portion of a plunger, the front wall comprising a generally flat contact surface configured to engage a funnel; and a locking member pivotably connected to an upper surface of the housing and extending adjacent to the upper surface of the housing, the locking member comprising a locking surface extending adjacent to the distal end of the housing, the locking member being movable in a locking position to lock the portion of the funnel with the housing.

Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

Abstract: A bone growth composition may include a cancellous portion and a noncancellous portion. The cancellous portion may be processed with an antimicrobial agent contact step and subsequent contact with a cryopreservative solution. In an embodiment, the cryopreservative solution is glycerol. In an embodiment, the bone growth composition includes a mix of cancellous chip formed from the cancellous portion and demineralized fibers formed from the noncancellous portion.

Abstract: A method of making an electron beam irradiated osteoinductive implant is provided. The method comprises exposing an osteoinductive implant containing demineralized bone matrix (DBM) fibers to electron beam radiation at a dose of from about 10 kilograys to 100 kilograys for a period of time. The electron beam irradiation reduces microorganisms in the osteoinductive implant, and the electron beam irradiated osteoinductive implant retains osteoinductive properties. Methods of implantation and an irradiated osteoinductive implant are also disclosed.

Abstract: A bone material dispensing apparatus for preparing, mixing, and dispensing bone material into a foldable container is provided. In some embodiments, the dispensing apparatus comprises a tray and a foldable container. The tray includes a mixing surface, a dispensing surface and a means to measure the amount of material to be dispensed. A kit including a tray, a foldable container, and a spatula are also provided. A method of using the dispensing apparatus to deliver the bone material to a bone detect is also provided.

Abstract: A bone implant holding and shaping tray is provided. The tray includes a first segment having a distal end and a first surface sized to hold and shape at least a portion of the bone implant with bone material. The tray includes a second segment having a second surface sized to hold and shape at least a portion of the bone implant with bone material, the second segment having a proximal end configured to be coupled to the distal end of the first segment so as to extend the first surface to hold and shape the bone implant. Methods of making and using the bone implant holding and shaping tray are also provided.

Abstract: Ablation devices useful for removing nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a cannula having an opening at a distal tip of the cannula, the opening configured for suction of a surgical site, and a movable tissue capture member having a portion disposed within the opening or adjacent to the cannula, the movable tissue capture member configured to capture tissue when moved in a first position. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.

Abstract: A device for hydrating particulate bone material is provided. The device comprises a tubular member having an interior surface and an exterior surface. The interior surface is configured to receive the particulate bone material and a hydration fluid. The exterior surface has a plurality of pores configured to allow the hydration fluid to flow into the interior surface of the tubular member and hydrate the particulate bone material. The plurality of pores are smaller in size than the particulate bone material. Methods of dispensing particulate the bone material are also provided.

Abstract: A surgical injection device includes at least one tubular element defining a passageway. The passageway is configured for disposal of a selected volume of an agent and an evacuator disposed within the passageway. An actuator is engageable with the evacuator to entirely expel the selected volume of the agent from the passageway to a selected site. Spinal constructs, implants, systems and methods are disclosed.

Abstract: A bone material dispensing system is provided. The bone material dispensing system comprises a loading device having a perimeter surrounding a base plane and a rim, the perimeter comprising a side wall extending along a longitudinal axis and a bar joining the side wall at a corner of the perimeter and extending in a direction transverse to the longitudinal axis, the base plane comprising a loading surface bordered by the side wall along the longitudinal axis, the loading surface having an end edge extending in a direction transverse to the longitudinal axis such that the side wall, the bar and the end edge form a rim adjacent to the loading surface and the bar. A method of loading bone material with the bone material dispensing system is also provided.

Abstract: A method for treating a spine comprises the steps of: inserting a surgical instrument into a tissue cavity, the surgical instrument including an image guide oriented relative to a sensor to communicate a signal representative of a position of the surgical instrument relative to the tissue cavity; displaying a selected configuration with a distal end of the surgical instrument in the tissue cavity; tracking movement of the selected configuration in the tissue cavity with a tracking device that communicates with a processor to generate data for display of the movement; and determining a volume of the tissue cavity based on the data. Systems, spinal constructs, implants and surgical instruments are disclosed.

Abstract: A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.