Abstract: The invention provides a long-acting parathyroid hormone peptide (PTH) that is retained in a subject's blood serum for periods of time that greatly exceed the natural hormone. The long-acting PTH is conjugated to at the carbon 3 position of a non-hormonal vitamin D via a scaffold of discreet length that facilitates its purification, detection, solubility, and efficacy at the PTH receptor (PTHR). The PTH may be conjugated to the non-hormonal vitamin D via a 36 mer poly(ethylene glycol) moiety (PTH-PEG36-VitD). The invention also provides optimized manufacturing methods and formulations. The PTH-PEG36-VitD has a vastly-improved serum half-life and bioavailability when compared to a non-conjugated PTH peptide. PTH-PEG36-VitD also significantly increases serum calcium, reduces urinary calcium, and reduces serum phosphate.

Abstract: A compressor including a housing, a shaft configured to be rotated relative to the housing to compress a refrigerant, a motor configured to drive the shaft, a lubrication system configured to supply lubricant to the compressor, and a bearing configured to support the shaft. The shaft includes a wear-resistant sleeve-like treatment on at least a portion of an outer surface of the shaft adjacent the bearing. The lubricant is a lubricant blend composition that includes two or more lubricants, the two or more lubricants including a first lubricant and a second lubricant. The first lubricant is present at a higher volume percentage than the second lubricant, and the first lubricant includes a higher viscosity than the second lubricant.

Abstract: A compressor including a housing, a shaft configured to be rotated relative to the housing to compress a refrigerant, a motor configured to drive the shaft, a lubrication system configured to supply lubricant to the compressor, and a bearing configured to support the shaft. The shaft includes a wear-resistant sleeve-like treatment on at least a portion of an outer surface of the shaft adjacent the bearing. The lubricant is POE oil or a lubricant blend composition that includes two or more lubricants, the two or more lubricants including a first lubricant and a second lubricant.

Abstract: A bioprocessing system comprising a series of processing stations for performing operations for bioprocessing is disclosed. The bioprocessing system includes an automated system comprising means for manipulating a fluid connection between a first container and a separable second container whereby to create an aseptic connection that enables a controlled transfer of fluid or cell material between the first container and the second container, wherein the means for manipulating a fluid connection is configured to create an aseptic connection that can be disconnected after the transfer of fluid or cell material is complete to enable a further such fluid connection to be manipulated between the first container and a separable third container, and means for controlling an automated sequence of operation of the processing stations.

Abstract: A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

Abstract: A counting mechanism (100) for a dispenser comprising: a first and a second housing part (110, 120) that are rotatable relative to each other; and a counting ring (130) disposed between the housing parts. The first housing part has a protrusion (111) which abuts the counting ring, holding a portion of the counting ring in contact with the second housing part. The relative rotation of the housing parts causes the protrusion to slide against the surface of the counting ring to drive a rolling movement of the counting ring around the circumference of the second housing part, such that a predefined rotation of the housing parts produces an incremental rotational displacement between the counting ring and second housing part to record a count. The counting mechanism provides a large gear reduction ratio in a compact form which is straightforward to manufacture and provides an accurate and reliable record of counts.

Abstract: A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material, and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

Abstract: Compositions, methods, systems, and applications herein are directed to lubricant blends that balance solubility and viscosity of a refrigerant, where in some cases the lubricant blends herein help reduce solubility of a refrigerant. A lubricant blend includes a mixture of two or more different types of lubricants to reduce refrigerant solubility.

Abstract: A variable orifice flow device controls the flow of refrigerant into a compressor motor housing in a compressor. The variable orifice flow device may include, for example, an electronic expansion valve, a thermal expansion valve, or a shuttling valve controlling the flow of refrigerant into a compressor motor housing. One or more flows of refrigerant may be through a fixed orifice, a valve seat of the variable orifice flow device, or leakage through a seal of the compressor motor housing, providing a baseline refrigerant flow to the inside of the compressor motor housing in addition to the flow through the variable orifice flow device.

Abstract: A counting mechanism (100) for a dispenser comprising: a first and a second housing part (110, 120) that are rotatable relative to each other; and a counting ring (130) disposed between the housing parts. The first housing part has a protrusion (111) which abuts the counting ring, holding a portion of the counting ring in contact with the second housing part. The relative rotation of the housing parts causes the protrusion to slide against the surface of the counting ring to drive a rolling movement of the counting ring around the circumference of the second housing part, such that a predefined rotation of the housing parts produces an incremental rotational displacement between the counting ring and second housing part to record a count. The counting mechanism provides a large gear reduction ratio in a compact form which is straightforward to manufacture and provides an accurate and reliable record of counts.

Abstract: A counting mechanism (100) for a dispenser comprising: a first and a second housing part (110, 120) that are rotatable relative to each other; and a counting ring (130) disposed between the housing parts. The first housing part has a protrusion (111) which abuts the counting ring, holding a portion of the counting ring in contact with the second housing part. The relative rotation of the housing parts causes the protrusion to slide against the surface of the counting ring to drive a rolling movement of the counting ring around the circumference of the second housing part, such that a predefined rotation of the housing parts produces an incremental rotational displacement between the counting ring and second housing part to record a count. The counting mechanism provides a large gear reduction ratio in a compact form which is straightforward to manufacture and provides an accurate and reliable record of counts.

Abstract: Compositions, methods, systems, and applications herein are directed to lubricant blends that balance solubility and viscosity of a refrigerant, where in some cases the lubricant blends herein help reduce solubility of a refrigerant. A lubricant blend includes a mixture of two or more different types of lubricants to reduce refrigerant solubility.

Abstract: Compositions, methods, systems, and applications herein are directed to lubricant blends that balance solubility and viscosity of a refrigerant, where in some cases the lubricant blends herein help reduce solubility of a refrigerant. A lubricant blend includes a mixture of two or more different types of lubricants to reduce refrigerant solubility.

Abstract: A counting mechanism (100) for a dispenser comprising: a first and a second housing part (110, 120) that are rotatable relative to each other; and a counting ring (130) disposed between the housing parts. The first housing part has a protrusion (111) which abuts the counting ring, holding a portion of the counting ring in contact with the second housing part. The relative rotation of the housing parts causes the protrusion to slide against the surface of the counting ring to drive a rolling movement of the counting ring around the circumference of the second housing part, such that a predefined rotation of the housing parts produces an incremental rotational displacement between the counting ring and second housing part to record a count. The counting mechanism provides a large gear reduction ratio in a compact form which is straightforward to manufacture and provides an accurate and reliable record of counts.

Abstract: A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material, and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

Abstract: A variable orifice flow device controls the flow of refrigerant into a compressor motor housing in a compressor. The variable orifice flow device may include, for example, an electronic expansion valve, a thermal expansion valve, or a shuttling valve controlling the flow of refrigerant into a compressor motor housing. One or more flows of refrigerant may be through a fixed orifice, a valve seat of the variable orifice flow device, or leakage through a seal of the compressor motor housing, providing a baseline refrigerant flow to the inside of the compressor motor housing in addition to the flow through the variable orifice flow device.

Abstract: According to a first aspect of the disclosure, a spray device is provided for generating an aerosol. The spray device comprises a reservoir for containing a store of a liquid; a delivery chamber for containing a dose of the liquid received from the reservoir prior to ejection; a perforate element comprising one or more nozzles; a drive mechanism configured to drive liquid from the delivery chamber through the one or more nozzles; and a fluid metering system. The fluid metering system comprises an actuated valve that is actuatable between a closed position and an open position. The opening and closing of the actuated valve can be sequenced to control the flow of fluid from the reservoir to the delivery chamber.

Abstract: A nozzle assembly, configured to receive fluid at pressures of greater than 1 bar. The nozzle assembly comprises a first perforate element (1) comprising one or more orifices (2), each orifice having an inlet and an outlet and a diameter of no more than 100 ?m, and at least one second perforate element (4) further comprising a plurality of orifices of a smaller size than the one or more orifices of the first perforate element (1) and having a larger number of orifices than the first perforate element (1). The second perforate element (4) is configured to act as a filter and the second perforate element (4) is attached to the first perforate element (1). A perpendicular distance between the first and second perforate elements (4) is less than the diameter of the largest orifice of the first perforate element (1).

Abstract: Compositions, methods, systems, and applications herein are directed to lubricant blends that balance solubility and viscosity of a refrigerant, where in some cases the lubricant blends herein help reduce solubility of a refrigerant. A lubricant blend includes a mixture of two or more different types of lubricants to reduce refrigerant solubility.

Abstract: A coolant sub-assembly is provided for use in a DNP apparatus. The sub-assembly comprises a plurality of concentric jackets surrounding an inner bore tube having first and second opposed ends. The jackets are adapted to inhibit heat flow to the inner bore tube, a DNP working region being defined within the inner bore tube where a DNP process will be performed on a sample in the DNP working region. A coolant supply path extends adjacent an outer surface of the inner bore tube at the DNP working region in order to cool said outer surface, whereby a sample holder assembly can be inserted through the first end of the inner bore tube to bring a sample holder into the DNP working region and can be moved through the second end of the inner bore tube. An auxiliary coolant supply path supplies coolant to a sample, located in use in the sample holder at the DNP working region, through at least one aperture in the inner bore tube wall at the DNP working region.