Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: A styrenic block copolymer composition comprising a hydrogenated high vinyl block copolymer and/or a high vinyl styrene-ethylene/butylene-styrene (SEBS) copolymer is mixed with a thermoplastic resin to form a thermoplastic elastomer (TPE) composition. TPE compositions comprising hydrogenated high vinyl block copolymers with relatively high molecular weight compounded with polypropylene provide compounds with high flow properties, high clarity, low haze, which exhibit higher tensile strength and elongation at break than prior art compositions.

Abstract: Described is a passenger seat having a seat bottom, a seat back, and a privacy divider. The seat back may have a stationary portion and a moveable portion, wherein the moveable portion is substantially upright in stowed position and is substantially horizontal over the seat bottom in a deployed position. The privacy divider may be coupled to at least an upper surface of the moveable portion in the deployed position.

Abstract: Polar modifier systems based on a blend of DTHFP, ETE, TMEDA, DMTHFMA and/or functionally similar compounds with BDMAEE and SMT are used to make block copolymers having high levels of pendant vinyl double bond repeat units, which is through highly selective 1,2-bond butadiene addition, low vinylcyclopentane formation, unimodal narrow molecular weight distribution, and a low level of randomized co-monomer repeat units. The block copolymers have very high levels of 1,2-vinyl content and high 3,4-vinyl bond addition of the conjugated diene monomer and low vinylcyclopentane content. The polar modifier systems provide a fast polymerization rate, with a unimodal narrow molecular weight distribution. The polar modifier systems allow operation at a higher temperature than in prior art systems, which reduces cooling requirements.

Abstract: Dual composition block copolymers made from conjugated diene and monovinyl aromatic monomers in batch organolithium initiated polymerization show advantageous performance in the production of crosslinked microcellular rubber compounds and pressure sensitive hot melt adhesives. The dual composition block copolymers are partially coupled with a coupling agent linking inner monovinyl aromatic blocks. Their un-coupled low molecular weight fraction has greater monovinyl aromatic repeating unit content than their coupled high molecular weight fraction. Crosslinked microcellular rubber articles made from the dual composition block copolymers exhibit lower density, smaller and more homogeneous cell size, higher softness and higher resiliency than prior art block copolymers. Rubber compounding of formulations comprising the dual composition block copolymers proceed at slightly lower torque and slightly lower temperature than with prior art block copolymers.

Abstract: Dual composition block copolymers made from conjugated diene and monovinyl aromatic monomers in batch organolithium initiated polymerization show advantageous performance in the production of crosslinked microcellular rubber compounds and pressure sensitive hot melt adhesives. The dual composition block copolymers are partially coupled with a coupling agent linking inner monovinyl aromatic blocks. Their un-coupled low molecular weight fraction has greater monovinyl aromatic repeating unit content than their coupled high molecular weight fraction. Crosslinked microcellular rubber articles made from the dual composition block copolymers exhibit lower density, smaller and more homogeneous cell size, higher softness and higher resiliency than prior art block copolymers. Rubber compounding of formulations comprising the dual composition block copolymers proceed at slightly lower torque and slightly lower temperature than with prior art block copolymers.

Abstract: Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.

Abstract: The present invention provides a controller for hydraulic apparatus (100). The controller is configured to determine (310) that an energy return criteria has been met by movement of a first movement component of a first hydraulic actuator. In response thereto, the controller is further configured to select (320) at least one among a plurality of energy control strategies based on at least one operational characteristic of the hydraulic apparatus, and to control (330) the hydraulic apparatus to implement the energy control strategy during movement of the first movable component in such a way as to meet the energy return criteria. The plurality of energy control strategies comprises a first energy control strategy and a second energy control strategy. The at least one operational characteristic of the hydraulic apparatus comprises an indication of an expected energy recovery of one or more of the energy control strategies.

Abstract: The present invention provides a controller for a hydraulic apparatus. The controller is configured to determine (410) that a mode change criteria has been met for the hydraulic apparatus. In response to the determination, the controller is configured to control (420) a valve arrangement to change a first actuator chamber of a hydraulic actuator between being fluidly connected to a hydraulic machine and fluidly isolated from a second chamber of the hydraulic actuator, and being fluidly connected to both the second actuator chamber and the hydraulic machine. Further in response to the determination, the controller is configured to control (430) the hydraulic machine to change a flow rate of hydraulic fluid flowing through the hydraulic machine to regulate a movement of the hydraulic actuator during the control of the valve arrangement.

Abstract: A method of the producing nanocrystalline silicon particulate from a silicate source includes removing contaminants, such as organics and heavy metals, and alumina from the silicate source by treating the silicate source with first and second acidic leaching solutions to form a first intermediate product. The first intermediate product is then reduced by reacting with a magnesium vapor to provide porous magnesiated silicon particulates as a second intermediate product. The second intermediate product is treated with a third leaching solution to remove magnesium and magnesium containing compounds form the second intermediate to thereby provide a third intermediate. The third intermediate is treated with a fourth leaching solution for removing remnant silica to thereby provide nanocrystalline porous silicon particles.

Abstract: Described is a mountable tray table assembly having a base attachable to a seat back of a passenger seat via an attachment mechanism. The base may include an opening for receiving a tray table and a projection for retaining the tray table within the base. The attachment mechanism may maintain the base at a set angle relative to a floor of a vehicle when the seat back is in an upright position and a reclined position.

Abstract: Described is a passenger seat having a seat bottom, a seat back, and a privacy divider. The seat back may have a stationary portion and a moveable portion, wherein the moveable portion is substantially upright in stowed position and is substantially horizontal over the seat bottom in a deployed position. The privacy divider may be coupled to at least an upper surface of the moveable portion in the deployed position.

Abstract: This invention relates to an electrolyte composition for a lithium ion battery comprising a lithium salt in a non-aqueous solvent containing an additive comprising a compound of formula R3SiOP(O)nF2; wherein each R independently is a hydrocarbyl group; and n is 0 or 1; and wherein the additive is substantially free from (R3SiO)3P(O)n and (R3SiO)2P(O)nF. Electrochemical cells and batteries also are described.

Abstract: Passenger seat assemblies may be used in vehicles such as aircraft. The passenger seat assembly includes a first wall, a second wall opposite from the first wall, and a passenger seat having a first side and a second side opposite from the first side. The passenger seat is positioned between the first wall and the second wall. The passenger seat assembly is positionable between a forward-facing configuration and an aft-facing configuration. In both the forward-facing configuration and the aft-facing configuration, the first wall is proximate to the first side of the passenger seat and the second wall is proximate to the second side of the passenger seat.

Abstract: Lithium tetrafluoro(malonato)phosphate compounds are useful as additives in lithium ion battery applications. The compounds are represented by Formula (I): MPF4[—O(C?O)—(CX?X?)—(C?O)O—]; wherein M is Li or Na; each X? and X? independently is selected from the group consisting of H, alkyl, fluoro-substituted alkyl, and F; or wherein the X? and X? together are —CR2—(CR?2)m—CR?2—; each R, R? and R? independently is selected from the group consisting of H methyl, trifluoromethyl, and F; and in is 0 or 1. These compounds can be prepared in high purity and a high yield by reaction of a metal hexafluorophosphate with a bis-silyl malonate compound. A similar oxalato compound, lithium tetrafluoro(oxalato)phosphate), can be made in the same manner, but using a bis-silyl oxalate in place of the bis-silyl malonate. Advantageously, the compounds can be formed, in situ, in a LiPF6-containing electrolyte solution.

Abstract: Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.

Abstract: A computer-implemented method for monitoring teeth position during treatment includes segmenting three-dimensional dental X-ray image data of teeth in a first treatment state and segmenting optical-scan (OS) image data of the teeth in a second treatment state. The position and orientation of each segmented X-ray crown is compared with the position and orientation of each segmented OS crown to determine any relative position differences and any relative orientation differences. Each segmented X-ray root is repositioned and/or reoriented according to the relative position differences and/or any relative orientation differences, if any, between the corresponding segmented OS and X-ray crowns. The OS crown and the X-ray root are then fused so simulate the roots in the second treatment state without exposing the patient to additional radiation.

Abstract: An electronically commutated hydraulic machine is coupled to a drivetrain. Working chambers of the hydraulic machine are connected to low and high pressure manifold through electronically controlled valves. The phase of opening and closing of the valves has a default. In order to avoid cycle failure due to acceleration events, for example due to backlash in the drivetrain, the phase of opening or closing of the electronically controlled valves is temporarily advanced or retarded from the default timing.