Patents by Inventor Daniel Adriano SILVA MANZANO

Daniel Adriano SILVA MANZANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • De novo design of potent and selective interleukin mimetics
    Patent number: 12240880
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: March 4, 2025
    Assignees: UNIVERSITY OF WASHINGTON, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • Split interleukin mimetics and their use
    Patent number: 12234572
    Abstract: Conditionally active receptor agonists that, when activated, bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor a subunit (IL˜13 R?) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: February 25, 2025
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Alfredo Quijano Rubio, Daniel Adriano Silva Manzano, David Baker, Umut Ulge, Marc Joseph Lajoie
  • De novo design of potent and selective interleukin mimetics
    Patent number: 12227553
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: March 21, 2023
    Date of Patent: February 18, 2025
    Assignees: UNIVERSITY OF WASHINGTON, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20240076342
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: March 21, 2023
    Publication date: March 7, 2024
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Kevin Jude, Brian Weitzner
  • Interleukin-2 Receptor Beta (IL-2RB) Binding Polypeptides
    Publication number: 20230340071
    Abstract: The present invention is related to, inter alia, de novo IL-2R13 binding polypeptides.
    Type: Application
    Filed: March 12, 2021
    Publication date: October 26, 2023
    Applicants: Neoleukin Therapeutics, Inc., University of Washington
    Inventors: Daniel Adriano Silva Manzano, Alfredo Quijano Rubio, Jesus Renan Vergara Gutierrez, Thomas Linsky, Jorgen Nelson
  • COMBINATION THERAPY USING AN IL-2 RECEPTOR AGONIST AND AN IMMUNE CHECKPOINT INHIBITOR
    Publication number: 20230331858
    Abstract: The present disclosure is directed to, inter alia, methods for modulating an immune response in a subject in need thereof using an IL-2 receptor agonist in combination with an immune checkpoint inhibitor.
    Type: Application
    Filed: November 9, 2020
    Publication date: October 19, 2023
    Inventors: Carl WALKEY, Jonathan DRACHMAN, Umut ULGE, Daniel Adriano SILVA MANZANO
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11655278
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: May 23, 2023
    Assignees: UNIVERSITY OF WASHINGTON, THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Umut Ulge
  • METHODS OF ADMINISTRATION OF IL-2 RECEPTOR AGONISTS
    Publication number: 20220370563
    Abstract: The present invention provides, inter alia, treatment regimens for administration of an IL-2 receptor agonist. The present invention is directed to, inter alia, methods for modulating an immune response in a subject in need thereof with an IL-2 receptor agonist. In some aspects, the immune response is an anti-cancer immune response.
    Type: Application
    Filed: October 22, 2020
    Publication date: November 24, 2022
    Inventors: Carl WALKEY, Jonathan DRACHMAN, Umut ULGE, Daniel Adriano SILVA MANZANO
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11401313
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?cheterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: August 2, 2022
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20220235110
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 28, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl WALKEY
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20220056095
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: September 13, 2021
    Publication date: February 24, 2022
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, David Baker, Kenan Christopher Garcia, Jamie Spangler, Alfredo Quijano Rubio
  • SPLIT INTERLEUKIN MIMETICS AND THEIR USE
    Publication number: 20220017588
    Abstract: Conditionally active receptor agonists that, when activated, bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor a subunit (IL˜13 R?) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.
    Type: Application
    Filed: November 19, 2019
    Publication date: January 20, 2022
    Inventors: Alfredo QUIJANO RUBIO, Daniel Adriano SILVA MANZANO, David BAKER, Umut ULGE, Marc Joseph LAJOIE
  • De novo design of potent and selective interleukin mimetics
    Patent number: 11117944
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: September 14, 2021
    Assignees: University Of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Brian Weitzner
  • De novo design of potent and selective interleukin mimetics
    Patent number: 10844105
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: November 24, 2020
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200347109
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??cheterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 23, 2020
    Publication date: November 5, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Brian Weitzner
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200339648
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 29, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey, Alfredo Quijano Rubio, Kevin Jude, Brian Weitzner
  • De Novo Design of Potent and Selective Interleukin Mimetics
    Publication number: 20200317744
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Application
    Filed: June 23, 2020
    Publication date: October 8, 2020
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl WALKEY
  • De novo designed hemagglutinin binding proteins
    Patent number: 10766929
    Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: September 8, 2020
    Assignee: University of Washington
    Inventors: David Baker, Aaron Arthur Chevalier, Gabriel Jacob Rocklin, Christopher David Bahl, Lance Joseph Stewart, Daniel Adriano Silva Manzano, Deborah L. Fuller, Merika Treants Koday, Jason Gilmore
  • De novo design of potent and selective interleukin mimetics
    Patent number: 10703791
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: July 7, 2020
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • DE NOVO DESIGNED HEMAGGLUTININ BINDING PROTEINS
    Publication number: 20200017552
    Abstract: Polypeptides that bind to viral hemagglotinin are disclosed and methods for their use in treating or limiting influenza infection, and diagnosing influenza infection.
    Type: Application
    Filed: March 15, 2018
    Publication date: January 16, 2020
    Inventors: David BAKER, Aaron Arthur CHEVALIER, Gabriel Jacob ROCKLIN, Christopher David BAHL, Lance Joseph STEWART, Daniel Adriano SILVA MANZANO, Deborah L. FULLER, Merika TREANTS KODAY, Jason GILMORE