Patents by Inventor Daniel Aird

Daniel Aird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use
    Patent number: 11524009
    Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 13, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Daniel Aird, Laura Corson, Ping Zhu, Markus Warmuth, Silvia Buonamici, Peter Gerard Smith, Peter Fekkes
  • COMBINATION COMPRISING AT LEAST ONE SPLICEOSOME MODULATOR AND AT LEAST ONE INHIBITOR CHOSEN FROM BCL2 INHIBITORS, BCL2/BCLXL INHIBITORS, AND BCLXL INHIBITORS AND METHODS OF USE
    Publication number: 20200352937
    Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.
    Type: Application
    Filed: October 30, 2018
    Publication date: November 12, 2020
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Daniel AIRD, Laura CORSON, Ping ZHU, Markus WARMUTH, Silvia BUONAMICI, Peter Gerard SMITH, Peter FEKKES
  • Parallel proximity ligation event analysis
    Patent number: 8481698
    Abstract: The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular components as determined by ligation of their respective nucleotide barcodes. As such, an intracellular component contact map may be constructed to fingerprint specific physiological and/or pharmacological intracellular conditions.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: July 9, 2013
    Assignees: The President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Erez Lieberman, Andreas Gnirke, Daniel Aird
  • Parallel Proximity Ligation Event Analysis
    Publication number: 20100240101
    Abstract: The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular components as determined by ligation of their respective nucleotide barcodes. As such, an intracellular component contact map may be constructed to fingerprint specific physiological and/or pharmacological intracellular conditions.
    Type: Application
    Filed: March 19, 2009
    Publication date: September 23, 2010
    Inventors: Erez Lieberman, Andreas Gnirke, Daniel Aird