Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

Abstract: The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.

Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

Abstract: One aspect of the present invention is directed to conjugates that comprise a linear polymer carrier, a linker and one or more drugs or imaging agents, as well as pharmaceutical compositions that include such conjugates. The drug may be a platinum-containing drug with a linker comprised of a modified amino acid. The conjugate may alternatively include a metal complexing ligand with a metal used for imaging or chemotherapeutic purposes. Another aspect of the invention is directed to formulations and processes for lyophilization of hyaluronan conjugates. Another aspect of the invention is directed to methods for treating and/or inhibiting cancer utilizing the conjugates and compositions described herein.

Abstract: The present invention is directed to drug conjugates of mTOR inhibitors comprising an mTOR inhibitor, such as rapamycin, conjugated to hyaluronic acid by a linker comprising an ester, carbonate, or carbamate. The present invention is also directed to pharmaceutical compositions comprising the drug conjugates, and methods of making and using the drug conjugates and the pharmaceutical compositions.

Abstract: An ergonomic electric guitar includes a neck frets, a plurality of strings, and a body. The body includes a bridge having a nominal string anchor point for the strings, an upper bass bout including a front strap attachment mechanism having a front strap attachment point that is disposed within a predefined region. The body also includes a rear strap attachment mechanism having a rear strap attachment point disposed within a predefined region and a lower bass bout including a generally wedge-shaped region disposed between a medial portion of a front face of the lower bass bout and extending to a peripheral side wall of the lower bass bout and the lower bass bout extends substantially beyond a first arc and is substantially within a second arc. The strings extend in a first direction from the bridge to a distal portion of the neck.

Abstract: A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820.

Abstract: An ergonomic electric guitar includes a neck frets, a plurality of strings, and a body. The body includes a bridge having a nominal string anchor point for the strings, an upper bass bout including a front strap attachment mechanism having a front strap attachment point that is disposed within a predefined region. The body also includes a rear strap attachment mechanism having a rear strap attachment point disposed within a predefined region and a lower bass bout including a generally wedge-shaped region disposed between a medial portion of a front face of the lower bass bout and extending to a peripheral side wall of the lower bass bout and the lower bass bout extends substantially beyond a first arc and is substantially within a second arc. The strings extend in a first direction from the bridge to a distal portion of the neck.