Abstract: 1. Analogs of 1-desamino-8-D-arginyl vasopressin with the following general formula: Mpa-Tyr-Phe-X-Y-Cys-Pro-D-Arg-Gly-NH2 wherein, X is an amino acid of the group consisting of alanine, asparagine, glutamine, isoleucine, leucine and valine; and Y is an amino acid of the group consisting of asparagine, glutamine, isoleucine, leucine and valine. 2. Analogs of 1-desamino-8-D-arginyl vasopressin, as claim 1, with the following general formula: wherein, X is an amino acid of the group consisting of alanine, asparagine, glutamine, isoleucine, leucine and valine; and is an amino acid of the group consisting of asparagine, glutamine, isoleucine, leucine and valine.

Abstract: A process for the production of cladribine, 2-chloro-2′-deoxyadenosine, is provided which involves the direct glycosylation of 2-chloro-6-aminopurine with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-&agr;-D-erythropentofuranose. The process is carried out by first forming the sodium salt of 2-chloro-6-aminopurine and allowing the sodium salt to react with 1-chloro-2-deoxy-3,5-di-O-p-toluoyl-&agr;-D-erythropentofuranose in the presence of a moderately polar solvent such as acetone. The final product, cladribine, is produced by removal of the p-toluoyl groups by the action of methanolic ammonia or methanolic sodium methoxide.