Abstract: A method of growing a transition metal dichalcogenide includes providing a substrate and positioning the substrate in a furnace. The method also includes reducing a transition metal compound to produce a plurality of reduced transition metal compounds. The plurality of reduced transition metal compounds is electrostatically aligned on the substrate. The method further includes reacting the plurality of reduced transition metal compounds with a chalcogen precursor to form one or more layers of a transition metal dichalcogenide.

Abstract: The present disclosure relates to single molecule tracking methods, including high throughput methods, for analyzing molecules in cell-free samples. The present disclosure further provides systems for performing such methods.

Abstract: The present disclosure provides methods and system for generating perspective data between two or more oral representations, comprising: presenting a first oral representation and a second oral representation on a digital display, wherein the second oral representation is configured to be manipulated by a user via a user input device; and generating perspective data between the manipulated second oral representation and the first oral representation, wherein the second oral representation is overlaid on the first oral representation such that the first representation is still visible on the digital display.

Abstract: A strainer basket system may include a reservoir in which a strainer basket is positioned and a chemical dispensing docking station. The chemical dispensing docking station may have a cavity that receives a container of chemical to be dispensed and a retention mechanism that is configured to mechanically engage and retain the container of chemical, when inserted into the cavity. The docking station may also include a piercing member positioned to pierce the container of chemical as the container of chemical is inserted into the cavity, thereby releasing chemical into the reservoir and/or strainer basket.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: High Throughput Single Molecule Tracking (htSMT) systems and methods are described wherein the htSMT workflows are adapted to characterize both known and novel pathway contributions to interaction networks in live cells, such as protein signaling interaction networks.

Abstract: The present disclosure provides, in some aspects, a humanized immunodeficient mouse model of human fibrosis. A humanized immunodeficient mouse model provided herein may be used, for example, for modeling human fibrosis, predicting human fibrosis, and testing putative fibrosis treatments.

Abstract: Techniques for monitoring a physiological condition of a patient are provided. In some embodiments, the techniques may involve obtaining a predictive association model associated with the patient, wherein the predictive association model comprises an association of two or more categorical state values that are predictive of the patient consuming a meal. The techniques may further involve obtaining real-time data associated with the patient. The techniques may further involve determining a current state of the patient based at least in part on the real-time data by transforming the real-time data into two or more current state categorical values. The techniques may further involve predicting consumption of a meal in response to determining the two or more current state categorical values match the two or more categorical state values of the association.

Abstract: This disclosure provides novel methods and systems for obtaining a retirement-oriented insurance product using the equity of residential property through a home equity insurance financing solutions (HEIFS) subsystem. In particular, the amount of equity of the residential property available for financing the insurance premium is not leveraged through the debt product, and the disclosed methods and systems do not require payments from the homeowner until the homeowner passes away or permanently moves out of the residential property.

Abstract: Systems and methods treat a heart valve using a magnetically adjustable annuloplasty ring attached to or near a cardiac valve annulus. A changing magnetic field may be used to selectively increase or decrease a circumference of, or otherwise modify the shape of, the implanted annuloplasty ring. The adjustable annuloplasty ring includes a tubular body member, one or more adjustable members, and an internal magnet within the tubular body member. The tubular body member and the one or more adjustable members form a ring shape. The internal magnet is configured to rotate in response to a rotating external magnetic field. The internal magnet is coupled to the one or more adjustable members to change a dimension of the ring shape as the internal magnet rotates. A system for treating a heart valve may include an external adjustment device having one or more external magnets to generate the rotating external magnetic field.

Abstract: A method includes receiving first information associated with a patient, second information associated with a provider, and third information associated with an order, and determining, using a multi-layer neural network, a medical indication corresponding to the order responsive to receiving the first information, the second information, and the third information.

Abstract: The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods treat a heart valve using a magnetically adjustable annuloplasty ring attached to or near a cardiac valve annulus. A changing magnetic field may be used to selectively increase or decrease a circumference of, or otherwise modify the shape of, the implanted annuloplasty ring. The adjustable annuloplasty ring includes a tubular body member, one or more adjustable members, and an internal magnet within the tubular body member. The tubular body member and the one or more adjustable members form a ring shape. The internal magnet is configured to rotate in response to a rotating external magnetic field. The internal magnet is coupled to the one or more adjustable members to change a dimension of the ring shape as the internal magnet rotates. A system for treating a heart valve may include an external adjustment device having one or more external magnets to generate the rotating external magnetic field.

Abstract: Rapidly administered emergency drug therapy represents life-saving treatment for a range of acute conditions including hypoglycemia, anaphylaxis, and cardiac arrest. A miniaturized (e.g., <3 cm3), lightweight (e.g., <2 g), minimally invasive fully wireless, emergency rescue device for the storage and active burst-release of indefinitely stable particulate forms of peptide and hormone drugs into subcutaneous sites for direct reconstitution in interstitial biofluids is disclosed. The device demonstrates a fast (e.g., <5 minutes) therapeutic effect. The device may deliver a drug across fibrotic tissue, which commonly accumulates following in vivo implantation, thereby accelerating systemic delivery. Fully wireless delivery of dry particulate glucagon in vivo is demonstrated, providing emergency hypoglycemic rescue in diabetic mice. Additionally, triggered delivery of epinephrine is demonstrated in vivo.

Abstract: In one embodiment of an audio system, the audio system comprises signal summation of two MEMS microphones in close acoustical proximity for speech frequencies to provide various benefits and improvements, including improvements to: speech intelligibility, signal-to-noise ratio, effective equivalent input noise, and at-a-distance acoustic signal reception.

Abstract: A laryngeal mask airway device (LMA) is disclosed comprising a ventilation conduit having operatively upper and lower ends, and a mask at the operatively lower end of the ventilation conduit. The mask has an inner surface forming a receptacle that is in fluid communication with the ventilation conduit, and an outer oropharyngeal surface facing away from the receptacle. The device includes a separate oropharyngeal suction conduit having an operatively lower end forming a collector defining a plurality of suction openings that extends across the oropharyngeal surface of the mask. In use secretions may be drawn through the suction openings into the oropharyngeal suction conduit for removal from the patient through the oropharyngeal suction conduit.