Patents by Inventor Daniel Arlow

Daniel Arlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REVERSIBLE TERMINATORS
    Publication number: 20240140977
    Abstract: The present application is directed to, in part, nucleotide analogs with a novel design of a 3?-OH reversible terminator that comprises an enzyme-cleavable linkage.
    Type: Application
    Filed: February 25, 2022
    Publication date: May 2, 2024
    Inventors: Daniel Arlow, Sebastian Palluk, Weidong Wu
  • Nucleic acid synthesis and sequencing using tethered nucleoside triphosphates
    Patent number: 11732283
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Grant
    Filed: January 9, 2022
    Date of Patent: August 22, 2023
    Assignee: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk
  • Polymerase-tethered nucleotides for nucleic acid synthesis
    Patent number: 11624079
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: April 11, 2023
    Assignee: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk
  • Nucleic Acid Synthesis and Sequencing Using Tethered Nucleoside Triphosphates
    Publication number: 20220251617
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Application
    Filed: March 9, 2022
    Publication date: August 11, 2022
    Applicant: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk
  • Nucleic Acid Synthesis and Sequencing Using Tethered Nucleoside Triphosphates
    Publication number: 20220205008
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Application
    Filed: January 9, 2022
    Publication date: June 30, 2022
    Applicant: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk
  • Polymerase-tethered nucleoside triphosphates for use in nucleic acid synthesis
    Patent number: 11254961
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk
  • Nucleic Acid Synthesis and Sequencing Using Tethered Nucleoside Triphosphates
    Publication number: 20190112627
    Abstract: Provided herein, among other things, is a conjugate comprising a polymerase and a nucleoside triphosphate, where the polymerase and the nucleoside triphosphate are covalently linked via a linker that comprises a cleavable linkage. A set of such conjugates, where the conjugates correspond to G, A, T (or U) and C is also provided. Methods for synthesizing a nucleic acid of a defined sequence are also provided. The conjugates can also be used for sequencing applications.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Applicant: The Regents of the University of California
    Inventors: Daniel Arlow, Sebastian Palluk