Patents by Inventor Daniel B. Graham

Daniel B. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED GENOMIC SEQUENCING IN SINGLE CELLS
    Publication number: 20260117280
    Abstract: Methods and compositions capable of obtaining paired transcriptome and genotype information from single cells in high throughput are provided. Disclosed methods and compositions obtain paired transcriptome and genotype information from single cells in a manner that is highly sensitive, capable of detecting even very low-level transcripts in single cells, and associating such low-level transcripts and abundance information with associated genotypes, within a single cell.
    Type: Application
    Filed: August 29, 2025
    Publication date: April 30, 2026
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Fei CHEN, Daniel B. GRAHAM, Kai LIU, Ramnik XAVIER
  • Systems and methods for MHC class II epitope prediction
    Patent number: 12374423
    Abstract: A system and method for prediction of immunodominant epitopes is provided herein. MHCII peptidomics was used to discover complex bacterial epitopes and host antigen processing pathways. Novel insights into the features of antigenicity are leveraged to build an algorithm for prediction of immunodominant epitopes. Use of immunodominant epitopes is described.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 29, 2025
    Assignees: THE BROAD INSTITUTE, INC, THE GENERAL HOSPTIAL CORPORATION
    Inventors: Ramnik Xavier, Daniel B. Graham, Chengwei Luo
  • SYSTEMS AND METHODS FOR MHC CLASS II EPITOPE PREDICTION
    Publication number: 20220293215
    Abstract: A system and method for prediction of immunodominant epitopes is provided herein. MHCII peptidomics was used to discover complex bacterial epitopes and host antigen processing pathways. Novel insights into the features of antigenicity are leveraged to build an algorithm for prediction of immunodominant epitopes. Use of immunodominant epitopes is described.
    Type: Application
    Filed: June 27, 2018
    Publication date: September 15, 2022
    Inventors: Ramnik Xavier, Daniel B. Graham, Chengwei Luo