Patents by Inventor Daniel B. Kassel

Daniel B. Kassel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Automated on-line evaporating light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
    Patent number: 6426006
    Abstract: Single pass methods and systems for measuring the total masses of individual compounds present in fluid samples in real time, and particularly for fluid samples prepared in microtiter plate format are provided. Individual compounds are isolated by fluid separation column (14). Portions of the individual compounds isolated by column (14) are analyzed by mass spectrometer (16), which determines their concentration on the basis of their molecular weights, and an evaporative light scattering detector (24), (which determines the total masses of each of the isolated compounds passing therethrough). Total collected masses of the individual compounds are calculated by determining the amount and portion of the isolated compounds diverted into evaporative light scattering detector (24) during a period of fraction collection.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: July 30, 2002
    Assignee: Deltagen Research Laboratories, L.L.C.
    Inventors: Robert A. Zambias, Daniel B. Kassel
  • Automated on-line evaporating light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
    Patent number: 6210571
    Abstract: Single pass methods and systems for measuring the total masses of individual compounds present in fluid samples in real time, and particularly for fluid samples prepared in microtiter plate format are provided. Individual compounds are isolated by fluid separation column (14). Portions of the individual compounds isolated by column (14) are analyzed by mass spectrometer (16), which determines their concentration on the basis of their molecular weights, and an evaporative light scattering detector (24), (which determines the total masses of each of the isolated compounds passing therethrough). Total collected masses of the individual compounds are calculated by determining the amount and portion of the isolated compounds diverted into evaporative light scattering detector (24) during a period of fraction collection.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: April 3, 2001
    Assignee: CombiChem, Inc.
    Inventors: Robert A. Zambias, Daniel B. Kassel
  • Automated on-line evaporation light scattering detection to quantify isolated fluid sample compounds in microtiter plate format
    Patent number: 6077438
    Abstract: Single pass methods and systems for measuring the total masses of individual compounds present in fluid samples in real time, and particularly for fluid samples prepared in microtiter plate format are provided. Individual compounds are isolated by fluid separation column (14). Portions of the individual compounds isolated by column (14) are analyzed by mass spectrometer (16), which determines their concentration on the basis of their molecular weights, and an evaporative light scattering detector (24), (which determines the total masses of each of the isolated compounds passing therethrough). Total collected masses of the individual compounds are calculated by determining the amount and portion of the isolated compounds diverted into evaporative light scattering detector (24) during a period of fraction collection.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: June 20, 2000
    Assignee: Combichem, Inc.
    Inventors: Robert A. Zambias, Daniel B. Kassel
  • Parallel fluid electrospray mass spectrometer
    Patent number: 6066848
    Abstract: A method of analyzing each of a plurality of fluid samples (11-16), comprising, simultaneously spraying a plurality fluid samples (11-16) from electrospray needle array (20) towards mass spectrometer (50); positioning blocking device (40) to block all but one (32-34) of fluid samples (31-34) from reaching mass spectrometer (50); moving electrospray needle array (20) and blocking device (40) relative to one another to permit at least two of the plurality of fluid samples (31, 32) to reach mass spectrometer (50) one at a time; and analyzing the mass spectrum of fluid samples (31, 32, 33, 34) sequentially reaching mass spectrometer (50).
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: May 23, 2000
    Assignee: CombiChem, Inc.
    Inventors: Daniel B. Kassel, Tao Wang, Lu Zeng