Patents by Inventor Daniel Bar-Shalom

Daniel Bar-Shalom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190298757
    Abstract: The present invention relates to a GI-cleansing composition comprising i) one or more gelling or swelling agents, ii) one or more laxative agents, iii) one of more taste-improving agents, and iv) water.
    Type: Application
    Filed: May 5, 2017
    Publication date: October 3, 2019
    Applicants: UNIVERSITY OF COPENHAGEN, SJÆLLANDS UNIVERSITETSHOSPITAL
    Inventors: Daniel BAR-SHALOM, Peter VILMANN, Anette MÜLLERTZ, Jacob Kolstrup ZEDERKOF, Hanne HOLM, Jette JACOBSEN
  • Patent number: 9937295
    Abstract: A syringe (1) for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe (1) comprises a syringe body (2) defining a first lumen (8), a first plunger (4) arranged movably in said first lumen (8), said first plunger (4) being hollow, thereby defining a second lumen (9) being separated from the first lumen (8), and a second plunger (5) arranged movably in said second lumen (9). A liquid diluent is contained in one of the first lumen (8) and the second lumen (9), and an active pharmaceutical ingredient is contained in the other of the first lumen (8) and the second lumen (9). The second plunger (5) is movable in such a manner that the active pharmaceutical ingredient and the liquid diluent are brought together, e.g.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: April 10, 2018
    Assignee: BIONEER A/S
    Inventor: Daniel Bar-Shalom
  • Patent number: 9884029
    Abstract: A oral pharmaceutical composition for controlled release of an opioid from a pharmaceutical composition is described that comprises (i) an erodible matrix composition comprising a mixture of (a) a polymer or a mixture of polymers (b) an opioid, and optionally, (c) one or more pharmaceutically acceptable excipients; and (ii) a single, substantially insoluble in and impermeable coating having two openings exposing at least one surface of the matrix, and comprising one or more polymers. The composition exhibits controlled release of the opioid by erosion of the matrix and exhibits a zero order release profile wherein about 75% w/w of the opioid is released from the composition within 4-10 hours when tested in a dissolution test as described herein.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: February 6, 2018
    Assignee: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Patent number: 9795745
    Abstract: A syringe for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe is designed in such a manner that it is ensured that substantially all of the mixed drug is ejected, and in such a manner that an active pharmaceutical ingredient can be lyophilized directly into the syringe. The syringe comprises a syringe body, a first plunger arranged movably inside the syringe body and a second plunger arranged movably inside the first plunger. In one aspect the second plunger comprises a first plunger part and a second plunger part, and the first and second plunger parts are adapted to cooperate to collapse the cavity of the first plunger. In a second aspect the cavity of the first plunger has a first diameter at a distal end and a second diameter at a proximal end, the first diameter being smaller than the second diameter.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: October 24, 2017
    Assignee: Bioneer A/S
    Inventors: Daniel Bar-Shalom, Lasse Johansson
  • Patent number: 9707179
    Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: July 18, 2017
    Assignee: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Publication number: 20170189333
    Abstract: An aqueous gel composition comprising a) water, at least one polysaccharide and at least one high molecular weight polyethylene oxide, wherein the water content is at least 90% by weight of the composition, and b) a local anaesthetic agent or an analgesic agent, for use as a local anaesthetic or analgesic. The aqueous gel shows transparency, lubricity, stringiness, elongation, extensiveness, and cohesiveness while being devoid of taste and smell and non-tacky or non-sticky.
    Type: Application
    Filed: May 21, 2015
    Publication date: July 6, 2017
    Inventors: Daniel Bar-Shalom, Jette Jacobsen, Kasper Dalby, Anne Marie Lynge Pedersen, Peter Vilmann
  • Patent number: 9694080
    Abstract: A pharmaceutical composition for controlled release of an active substance, the composition being a matrix composition of: (a) a substantially water soluble or crystalline polymer, (b) an active substance, and optionally, (c) one or more pharmaceutically acceptable excipients having a water solubility of at least 1 mg/ml at ambient temperature. The matrix composition does not contain a water dispersible or water soluble surface active agent that has at least one domain, which is compatible with the polymer in the matrix composition, and which substantially eliminates water diffusion between the interface between the polymer crystals.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 4, 2017
    Assignee: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Anne-Marie Lademann, Christine Andersen
  • Patent number: 9642809
    Abstract: Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: May 9, 2017
    Assignee: EGALET LTD.
    Inventors: Pernille Hoyrup Hemmingsen, Anders Vagno Pedersen, Daniel Bar-Shalom
  • Publication number: 20160361269
    Abstract: A composition for controlled release of an opioid from a pharmaceutical composition, the method comprises controlling the release of at least one opioid into an aqueous medium by erosion of at least one surface of a pharmaceutical composition comprising I) a matrix composition comprising a) polymer or a mixture of polymers, b) an opioid and, optionally, c) one or more pharmaceutically acceptable excipients, and (i) a coating. The matrix composition has a conus-like shape so the surface area exposed to the aqueous medium increases at least during initial erosion of the matrix composition, and the dissolution of the opioid—when tested in a Dissolution Test as described herein with or without application of sinkers—results in a zero order release of at least 80% of the opioid contained in the composition. Such compositions are especially suitable for controlled release of an opioid to obtain a delayed pead concentration and a prolonged therapeutically effective plasma concentration upon oral administration.
    Type: Application
    Filed: May 9, 2016
    Publication date: December 15, 2016
    Applicant: Egalet Ltd.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Patent number: 9375428
    Abstract: Described are controlled release oral pharmaceutical composition comprising an erodible matrix composition comprising a polyethylene oxide, a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt, complex, solvate or anhydrate thereof, or a mixture thereof and, optionally, one or more pharmaceutically acceptable excipients, and a coating on the matrix composition, wherein the coating has at least one opening exposing a surface of an end portion of the matrix composition, thereby allowing controlled release of the opioid by erosion of the matrix surface, wherein the composition exhibits zero order release of at least 80% of the opioid contained in the composition. The matrix may have a cylindrical shape having a long axis and a conus-shaped end portion having a largest diameter and a smallest diameter, such that the surface area exposed increases during erosion of the conus-shaped end portion.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: June 28, 2016
    Assignee: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Publication number: 20160074586
    Abstract: Disclosed herein is a ready-to-use injection device for single use and a container for such device. The container comprises at least one first closed chamber for containine an active substance and optionally a second closed chamber for containing a quid substance comprising an active substance or a solvent. The two chambers are separated by a separation wall which is impermeable and breakable upon exertion of an external force, resulting in enhanced mixing of the substances contained in the device with a minimal formation of air bubbles. The present injection device is safe and particularly well suited for enhanced mixing of pharmaceutically active compositions to be injected in patients and can be used for vaccination programs.
    Type: Application
    Filed: May 2, 2014
    Publication date: March 17, 2016
    Applicant: INJECTOR ApS
    Inventors: Morten Mernøe, Daniel Bar-Shalom
  • Publication number: 20150190584
    Abstract: A syringe for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe is designed in such a manner that it is ensured that substantially all of the mixed drug is ejected, and in such a manner that an active pharmaceutical ingredient can be lyophilized directly into the syringe. The syringe comprises a syringe body, a first plunger arranged movably inside the syringe body and a second plunger arranged movably inside the first plunger. In one aspect the second plunger comprises a first plunger part and a second plunger part, and the first and second plunger parts are adapted to cooperate to collapse the cavity of the first plunger. In a second aspect the cavity of the first plunger has a first diameter at a distal end and a second diameter at a proximal end, the first diameter being smaller than the second diameter.
    Type: Application
    Filed: June 25, 2013
    Publication date: July 9, 2015
    Inventors: Daniel Bar-Shalom, Lasse Johansson
  • Publication number: 20150079150
    Abstract: A composition for controlled release of an opioid from a pharmaceutical composition, the method comprises controlling the release of at least one opioid into an aqueous medium by erosion of at least one surface of a pharmaceutical composition comprising I) a matrix composition comprising a) polymer or a mixture of polymers, b) an opioid and, optionally, c) one or more pharmaceutically acceptable excipients, and (i) a coating. The matrix composition has a conus-like shape so the surface area exposed to the aqueous medium increases at least during initial erosion of the matrix composition, and the dissolution of the opioid-when tested in a Dissolution Test as described herein with or without application of sinkers-results in a zero order release of at least 80% of the opioid contained in the composition. Such compositions are especially suitable for controlled release of an opioid to obtain a delayed pead concentration and a prolonged therapeutically effective plasma concentration upon oral administration.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 19, 2015
    Applicant: Egalet Ltd.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Publication number: 20150037417
    Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.
    Type: Application
    Filed: July 15, 2014
    Publication date: February 5, 2015
    Applicant: Egalet Ltd.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Publication number: 20150024048
    Abstract: Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof.
    Type: Application
    Filed: July 29, 2014
    Publication date: January 22, 2015
    Inventors: Pernille Hoyrup Hemmingsen, Anders Vagno Pedersen, Daniel Bar-Shalom
  • Patent number: 8821928
    Abstract: Layered pharmaceutical composition suitable for oral use in the treatment of diseases where absorption takes place over a large part of the gastrointestinal tract. The composition comprising A) a solid inner layer comprising i) an active substance, and ii) one or more disintegrants/exploding agents, one of more effervescent agents or a mixture thereof.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: September 2, 2014
    Assignee: Egalet Ltd.
    Inventors: Pernille Hoyrup Hemmingsen, Anders Vagno Pedersen, Daniel Bar-Shalom
  • Publication number: 20140236121
    Abstract: A syringe (1) for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe (1) comprises a syringe body (2) defining a first lumen (8), a first plunger (4) arranged movably in said first lumen (8), said first plunger (4) being hollow, thereby defining a second lumen (9) being separated from the first lumen (8), and a second plunger (5) arranged movably in said second lumen (9). A liquid diluent is contained in one of the first lumen (8) and the second lumen (9), and an active pharmaceutical ingredient is contained in the other of the first lumen (8) and the second lumen (9). The second plunger (5) is movable in such a manner that the active pharmaceutical ingredient and the liquid diluent are brought together, e.g.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 21, 2014
    Applicant: BIONEER A/S
    Inventor: Daniel Bar-Shalom
  • Patent number: 8808745
    Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: August 19, 2014
    Assignee: Egalet Ltd.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
  • Publication number: 20140120164
    Abstract: A pharmaceutical composition for controlled release of an active substance, the composition being a matrix composition of: (a) a substantially water soluble or crystalline polymer, (b) an active substance, and optionally, (c) one or more pharmaceutically acceptable excipients having a water solubility of at least 1 mg/ml at ambient temperature. The matrix composition does not contain a water dispersible or water soluble surface active agent that has at least one domain, which is compatible with the polymer in the matrix composition, and which substantially eliminates water diffusion between the interface between the polymer crystals.
    Type: Application
    Filed: August 23, 2013
    Publication date: May 1, 2014
    Applicant: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Anne-Marie Lademann, Christine Andersen
  • Publication number: 20140093569
    Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.
    Type: Application
    Filed: August 23, 2013
    Publication date: April 3, 2014
    Applicant: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen