Abstract: The present disclosure provides, among other things, methods of drying porcine thyroid gland material and manufacturing DTE comprising vacuum drying porcine thyroid gland material in a way such that the temperature of the porcine thyroid gland material is maintained above a threshold temperature. Since applying vacuum, or reducing pressure, has a cooling effect on the porcine thyroid gland material, maintaining the porcine thyroid gland material above a threshold temperature can be achieved by gradually reducing pressure while simultaneously increasing the heat applied to the porcine thyroid gland material during the period of gradual pressure change. Such methods are advantageous in reducing bioburden (killing and impeding the growth of microorganisms) while maintaining therapeutic levels of thyroid hormones, as compared to certain methods of drying porcine thyroid gland material and/or manufacturing DTE known in the art.

Abstract: A device and method for processing a 3D polymer structure with a paramagnetic substance distributed homogeneously in the material of the 3D polymer structure is disclosed. A magnetic field generator generates a static magnetic field in a working zone of the device. Gradient coils for generating magnetic gradient fields in at least all three spatial directions x, y, z, where the paramagnetic substance can be spatially encoded in a defined voxel V of the 3D polymer structure. An RF field generator irradiates RF radiation into the working zone. A control unit controls the RF field generator in such a way that the spatially encoded paramagnetic substance in the voxel V can be excited by a field frequency of the RF radiation which is tuned to the paramagnetic substance, in order to destroy or decompose the 3D polymer structure solely in the defined voxel V.

Abstract: An apparatus for generating a 3D structure is disclosed. A magnetic field generator generates a static magnetic field Bo in a working zone of the apparatus, in which a polymer precursor having at least one paramagnetic substance can be arranged. Gradient coils for generating magnetic gradient fields in all three spatial directions x, y, z, by means of which gradient coils the paramagnetic substance can be spatially encoded in a defined voxel V of the polymer precursor. A radio-frequency field generator is for irradiating RF radiation into the working zone. A control unit is configured to control the RF field generator in such a way that the spatially encoded paramagnetic substance in the voxel V can be excited by means of a field frequency of the RF radiation tuned to the paramagnetic substance in order to trigger the polymerization of the polymer precursor in the defined voxel V.

Abstract: The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Abstract: The invention relates to a method for determining deformations on an object, wherein the object is illuminated and moved while being illuminated. In the process, the object is observed by means of at least one camera and at least two camera images are generated at different times by said camera. In the camera images, polygonal chains are ascertained in each case for reflections at the object caused by form features. The form features are classified on the basis of the behavior of the polygonal chains over the at least two camera images and a two-dimensional representation is generated, the latter representing a spatial distribution of deformations. Moreover, the invention relates to a corresponding apparatus.

Abstract: A packaging for sterile products, comprising a tray and a hood made from cellular plastic material comprising at least two covering sheets held at a distance from one another by a plurality of spacers having cells longitudinally parallel to each other, the tray and the hood comprising a base and sidewalls cut from a plate of said material and with at least one of said sidewalls having double thickness and being formed by folding two panels of the plate around the folding lines perpendicular to the direction of said spacers. The interior covering sheets are perforated to allow the passage of a sterilizing gas through said covering sheet, the perforations allowing the passage of the gas but preventing the passage of dust, wide cut-outs traversing at least the other covering sheet of the plate in order to ensure communication of said cells with the outside and being provided along the folding lines of said panels.

Abstract: A packaging for sterile products, comprising a tray and a hood made from cellular plastic material comprising at least two covering sheets held at a distance from one another by a plurality of spacers having cells longitudinally parallel to each other, the tray and the hood comprising a base and sidewalls cut from a plate of said material and with at least one of said sidewalls having double thickness and being formed by folding two panels of the plate around the folding lines perpendicular to the direction of said spacers. The interior covering sheets are perforated to allow the passage of a sterilising gas through said covering sheet, the perforations allowing the passage of the gas but preventing the passage of dust, wide cut-outs traversing at least the other covering sheet of the plate in order to ensure communication of said cells with the outside and being provided along the folding lines of said panels.

Abstract: A sanitary fitting includes a joint arrangement having a support connection piece that defines an abutment face that is at least approximately flat; a joint part that rests flat against the abutment face by way of an at least approximately flat mating face, and defines a neutral position; a spring that is supported at one end against the support connection piece and at the other end against the joint part, the spring using a spring force to push the joint part against the abutment face by way of the mating face; and a rod-like extremity that is arranged on the joint part at a fixed angle in relation to the mating face.

Abstract: A sanitary fitting includes a cold water connection; a hot water connection; a mixed water outlet; a valve device for setting a mixed water temperature and a mixed water throughflow rate, wherein the valve device is connected to the cold water connection and the hot water connection at one end and is connected to the mixed water outlet at the other end; an electrical controller for actuating a valve; and a control signal transmitter for generating an input signal to the controller, wherein the valve is an integral constituent part of the valve device, and the controller actuates the valve device as a function of the input signal of the control signal transmitter such that a mixed water temperature and a mixed water throughflow rate are set.

Abstract: A sanitary fitting includes a light-permeable water-carrying outflow pipe that has (i) an exposed end face and (ii) an input face located upstream of the exposed end face. A light source, preferably including light emitting diodes (LED), inputs light into the outflow pipe through the input face. The light emerges from the outflow pipe at the end face, and may also emerge at an exposed outer peripheral surface area of the outflow pipe. The outflow pipe has a stationary first outflow pipe piece with the input face and a rotatable second outflow pipe piece with the exposed end face.

Abstract: A sanitary fitting includes a joint arrangement having a support connection piece that defines an abutment face that is at least approximately flat; a joint part that rests flat against the abutment face by way of an at least approximately flat mating face, and defines a neutral position; a spring that is supported at one end against the support connection piece and at the other end against the joint part, the spring using a spring force to push the joint part against the abutment face by way of the mating face; and a rod-like extremity that is arranged on the joint part at a fixed angle in relation to the mating face.

Abstract: A sanitary fitting includes a cold water connection; a hot water connection; a mixed water outlet; a valve device for setting a mixed water temperature and a mixed water throughflow rate, wherein the valve device is connected to the cold water connection and the hot water connection at one end and is connected to the mixed water outlet at the other end; an electrical controller for actuating a valve; and a control signal transmitter for generating an input signal to the controller, wherein the valve is an integral constituent part of the valve device, and the controller actuates the valve device as a function of the input signal of the control signal transmitter such that a mixed water temperature and a mixed water throughflow rate are set.

Abstract: A sanitary fitting includes a light-permeable water-carrying outflow pipe that has (i) an exposed end face and (ii) an input face located upstream of the exposed end face. A light source, preferably including light emitting diodes (LED), inputs light into the outflow pipe through the input face. The light emerges from the outflow pipe at the end face, and may also emerge at an exposed outer peripheral surface area of the outflow pipe. The outflow pipe has a stationary first outflow pipe piece with the input face and a rotatable second outflow pipe piece with the exposed end face.

Abstract: An NMR apparatus comprising an NMR magnet system disposed in a first cryocontainer (2) of a cryostat (9), and an NMR probe head (1), wherein the first cryocontainer (2) is installed in an evacuated outer jacket and is surrounded by a radiation shield (24) and/or a further cryocontainer (3), wherein a cooling device is provided for cooling the NMR probe head (1) and a cryocontainer (2, 3), which comprises a cold head (4, 4a, 4b, 4c) with several cold stages (12a, 12b, 12c, 18a, 18b, 18c, 19a), wherein one cold stage (12a, 12b, 12c, 18a, 18b, 18c, 19a) is connected to a heat-transferring device, and wherein a cooling circuit is provided between the cooling device and the NMR probe head (1), is characterized in that the cooling device is disposed in a separate, evacuated housing (6) which is positioned directly above the cryostat (9), wherein the heat-transferring device is inserted directly into suspension tubes (29a, 29c) of the cryocontainer (2, 3) and/or is in contact with the radiation shield (24).

Abstract: An NMR spectrometer comprising an NMR magnet system (27) disposed in a helium tank of a cryostat and an NMR probe head (11) disposed in a room temperature bore of the cryostat, which contains a cooled RF resonator (9) for receiving NMR signals from a sample to be investigated, and a cooled pre-amplifier (10), wherein the NMR probe head (11) is cooled by a common multi-stage compressor-operated refrigerator (2), wherein the refrigerator (2) comprises a cold head and several heat exchangers (5, 6) at different temperature levels, wherein the refrigerator (2) is disposed at a spatial separation from the cryostat in a separate, evacuated and thermally insulated housing (1) and wherein at least one cooling circuit with cooling lines, which are thermally insulated by a transfer line (13, 14) is disposed between the housing (1) containing the heat exchangers (5, 6) and the NMR probe head (11), is characterized in that additional cooling lines to an LN2 tank (18) or radiation shield (21) disposed in the cryostat and

Abstract: Packing box (2) of polygonal general shape that widens out, is made from a flat cellular plastic blank that is cut and folded. The box (2) comprises a base (4) and side walls (5, 6) which are formed from side panels of the blank and are joined together, and an outer reinforcing frame (7), used for holding the box. The frame runs around the side walls (5, 6) and comprises frame members (8, 9) joined together and fixed to the side walls (5, 6). The frame members are formed from at least four flaps extending from side panels of the blank and rolled up spiral-fashion.

Abstract: The data processing circuit has a self-timed instruction execution unit, which operates asynchronously, signalling the completion of processes and starting subsequent processes in response to such signalling. In order to satisfy real time constraints upon program execution ready signals generated after completion of selected instructions are gated with a timer signal before they are used to start a next instruction. In an embodiment, the amount of time left between the ready signal is used to start a next instruction is measured and used to regulate a power supply voltage of the instruction execution unit so that it is just high enough to make the instruction execution unit sufficiently fast to meet the real time constraints.