Abstract: Provided is a method including receiving a request for a media choreography asset to play on a first client computing device that has control over at least one connected device that has a feature configured to provide a sensory output to a user; obtaining the media choreography asset that includes a primary media track that includes at least one content track to be presented via an audio or video system, and the media choreography asset includes one or more triggers that include a first set of instructions to operate a first set of the at least one connected device at a first timecode and a first duration during a playback of the primary media track; and providing the media choreography asset to the first client computing device.

Abstract: The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: A traction battery assembly includes an enclosure assembly having an interior area, and a pressure relief device having a valve member movable from a closed position to an unlocked-release position, and movable from the unlocked-release position to a locked-release position. The valve member in the closed position blocks flow through the pressure relief device from the interior area. The valve member in the unlocked-release position permits flow from the interior area. The valve member in the locked-release position permits flow from the interior area. A ratchet mechanism that holds the valve member in the locked-release position.

Abstract: The present disclosure provides, in various embodiments, stable injectable particle suspensions of therapeutic biologics and hyaluronan degrading agents that permit administration without the need for resuspension. In particular, the compositions disclosed herein are highly concentrated, low-volume injectable particle suspensions that increase bioavailability of therapeutic biologics.

Abstract: Provided herein are materials and methods for plasma-free labeling of biological molecules with trifluoromethyl and hydroxyl radicals generated using a peroxide and a radical precursor such as sodium triflinate. The methods provided herein find use in labeling of molecules, such as cell-membrane proteins, in live, intact cells.

Abstract: Provided herein are materials and methods for in vivo labeling of membrane proteins using plasma-induced modification of biomolecules (PLIMB).

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: The present disclosure relates to a processes and systems for producing fuels from biomass with high carbon conversion efficiency. The processes and systems described herein provide a highly efficient process for producing hydrocarbons from biomass with very low Green House Gas (GHG) emissions using a specific combination of components, process flows, and recycle streams. The processes and systems described herein provide a carbon conversion efficiency greater than 95% with little to no GHG in the flue gas due to the novel arrangement of components and utilizes renewable energy to provide energy to some components. The system reuses water and carbon dioxide produced in the process flows and recycles naphtha and tail gas streams to other units in the system for additional conversion to syngas to produce hydrocarbon-based fuels.

Abstract: A device and method for transmitting vibration to the heart during open-heart surgery in order to dislodge air bubbles formed along interior walls of the heart so that they may be removed from the body, rather than allowed to enter the circulatory system.

Abstract: The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: Provided herein are materials and methods for plasma-based multiplexed labeling of biological molecules. In some aspects, provided herein is an optimized method for simultaneous labeling of proteins with trifluoromethyl, nitro, and hydroxyl radicals generated by a plasma in a single reaction vial, such as for protein footprinting.

Abstract: Provided is a method including providing a first audio content object that includes a plurality of audio content segments to a set of user computing devices. Each audio content segment of the plurality of audio content segments is associated with a first version. The method also includes obtaining a second version of a first audio content segment and updating the first version of the first audio content segment to the second version to generate a second audio content object that includes the second version of the first audio content segment and at least a first version of a second audio content segment. The method also includes providing the second audio content object to at least a first portion of the set of user computing devices and indicating a version history of the first audio content segment to at least the first portion of the set of user computing devices.

Abstract: Provided are mechanisms that allow automatic media content layering. The systems and methods obtain a media content list that includes a plurality of different types of media content segment entries. Media content tracks are determined from the plurality of media content segment entries and are based on the type of those entries. Media content track features are determined from the media content segment entries where those features are used to adjust the media content tracks, layering of multiple media content tracks, adjusting media content segments that make up the media content tracks or other features. A media content layered object is then generated based on the media content track features and the media content tracks. An action, such as storage, may be performed on the generated media content layered object.

Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: The present invention provides alternate means in form of a medicinal composition comprising botanical extracts comprised of an organic liquid extract derived from Laminaria japonica and an organic liquid extract derived from Andrographis paniculate along with other components as disclosed herein for the prevention of viral binding, uptake, replication, infection, and disease caused by viral pathogens. Combined the aforementioned organic botanical extracts produce strong additivity and synergistic effect against the viral pathogens contributing towards significant reduction in viral binding, uptake, replication, infection, and disease. Also disclosed are the methods to formulate the aforementioned medicinal composition and dosage forms for use in a method for prophylactic treatment and prevention of viral binding, uptake, replication, infection, and disease caused by viral pathogens in an individual, which is also disclosed herein.

Abstract: “Spacerless” cell block assemblies are provided for traction battery packs. Exemplary cell block assemblies may include a battery cell grouping, a bus bar module, and a heat exchanger plate. The battery cell grouping may be arranged between the bus bar module and the heat exchanger plate. The bus bar module may provide first spacer features, and the heat exchanger plate may provide second spacer features. The first and second spacer features cooperate to maintain air gaps between adjacent battery cells of the battery cell grouping.