Patents by Inventor Daniel BIASSE

Daniel BIASSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIGAND-DRUG-CONJUGATES AS SUBSTRATES FOR SELECTIVE CLEAVAGE BY THE EXOPEPTIDASE ACTIVITY OF CATHEPSIN B
    Publication number: 20220062371
    Abstract: The present invention relates to ligand-drug-conjugates for the treatment of disease. In particular, the present invention relates to ligand-drug-conjugates comprising a linker system, which is selectively recognized and cleaved by the exopeptidase (i.e. carboxydipeptidase) activity of Cathepsin B, resulting in improved intracellular delivery of a drug to a target cell. The present invention also relates to ligand-drug-conjugates for the intracellular delivery of cytotoxic agents in tumor cells.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 3, 2022
    Inventors: Manfred MUTTER, Nathalie BELLOCQ, Daniel BIASSE, Alain RAZANAME, Léo MARX, Christophe CHARDONNENS, Patrick GARROUSTE