Abstract: A stylet may be used to perform measurements via an indwelling catheter. The stylet can be configured in various ways to selectively occlude the indwelling catheter. Because of this selective occlusion, the indwelling catheter can be used for blood draws, infusions, and other functions even while the stylet remains extended through the indwelling catheter.

Abstract: A catheter system may include a catheter assembly and a catheter delivery device. The catheter assembly may include a catheter adapter, which may include a catheter adapter distal end, a catheter adapter proximal end, and a catheter adapter lumen extending through the catheter adapter distal end and the catheter adapter proximal end. The catheter assembly may include a primary catheter extending from the catheter adapter distal end. The catheter delivery device may include a housing, which may include a housing distal end coupled to the catheter assembly, a housing proximal end, and a housing lumen extending through the housing distal end and the housing proximal end. A secondary catheter may be disposed within the housing. The secondary catheter may be configured to move distally through the catheter assembly in response to a fluid pressure provided by a fluid delivery device coupled to the housing proximal end.

Abstract: A catheter system may be configured such that in response to the movement from a first position to a second position, a guidewire slider may push out on a catheter hub slider. The catheter hub slider is then removed from contact with a needle hub and may slide distally. The guidewire slider and the catheter hub slider may each include a tab to facilitate one-handed advancement. Another catheter system may be configured such that in response to movement of a guidewire slider from a proximal position to a distal position, a guidewire carriage uncouples from the guidewire slider. Further advancement of the guidewire slider may not advance the guidewire. Another catheter system may be configured such that in response to movement of a guidewire slider from a proximal position, the guidewire slider is configured to engage the safety housing and advance a catheter and a guidewire together.

Abstract: A securement device for securing a catheter assembly may include one or more anchor pads having an adhesive surface. The securement device may include a retainer positioned on the one or more anchor pads. The retainer may include one or more retaining edges configured to contact a wing of the catheter assembly. The retainer may include a catheter angle adjuster. The securement device may include an extension tube securement element disposed on the one or more anchor pads. Another securement device for securing a catheter assembly may include a bracelet configured to wrap around a wrist of a patient. Another securement device for securing a catheter assembly may include a retainer having a bottom cover and a top cover hingedly coupled to the bottom cover. When the top cover is in the closed position, the retainer may secure the catheter assembly between the top cover and the bottom cover.

Abstract: A measurement device may be used with an indwelling catheter. The measurement device can include a housing from which a stylet extends. The housing can include circuitry for receiving measurements from one or more sensors on the stylet. The circuitry may also include a wireless module for wirelessly transmitting the measurements to a patient's electronic medical record or monitoring device.

Abstract: Provided herein is a blood draw syringe connectable to a vascular access device for performing a blood draw. The blood draw syringe includes a syringe barrel and a plunger assembly. The plunger assembly includes a plunger rod and a stopper positioned at the distal end of the plunger rod, with the plunger assembly moveable within the syringe barrel to move the stopper between a starting position and a stop position, with a first volume provided in the chamber with the stopper at the starting position and a second volume provided in the chamber with the stopper at the stop position. The syringe is configured to enable pre-setting of the plunger assembly within the syringe barrel prior to a blood draw, with the stopper being positioned at the starting to provide a first volume that limits a maximum vacuum pressure in the syringe barrel during the blood draw.

Abstract: Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of SARS-CoV-2, including SARS-CoV-2 variants, or other coronaviruses from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.

Abstract: A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

Abstract: Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the detection of target nucleic acids, including those from microbes and/or from infectious agents such as SARS-CoV-2 and other viruses. Embodiments described herein are designed to enable processing and analysis of the sample to detect target nucleic acids within the sample without requiring extraction and/or isolation of nucleic acid from the sample prior to subsequent processing steps. Samples analyzed can thus be “crude” biological samples that do not require pre-processing prior to placement in the workflow.

Abstract: A catheter assembly may include a catheter adapter, which may include a distal end and a proximal end. The catheter assembly may include a catheter extending from the distal end of the catheter adapter. The catheter may include a shaft and a lumen extending through the shaft. The shaft may include a wall and multiple reinforcement fibers within the wall. Each of the reinforcement fibers may have a greater tensile strength than the wall, facilitating kink-resistance and strength of the catheter.

Abstract: A catheter system may include a catheter assembly and a catheter delivery device. The catheter assembly may include a catheter adapter, which may include a catheter adapter distal end, a catheter adapter proximal end, and a catheter adapter lumen extending through the catheter adapter distal end and the catheter adapter proximal end. The catheter assembly may include a primary catheter extending from the catheter adapter distal end. The catheter delivery device may include a housing, which may include a housing distal end coupled to the catheter assembly, a housing proximal end, and a housing lumen extending through the housing distal end and the housing proximal end. A secondary catheter may be disposed within the housing. The secondary catheter may be configured to move distally through the catheter assembly in response to a fluid pressure provided by a fluid delivery device coupled to the housing proximal end.

Abstract: A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

Abstract: A catheter system may include a catheter assembly and a catheter delivery device. The catheter assembly may include a catheter adapter, which may include a catheter adapter distal end, a catheter adapter proximal end, and a catheter adapter lumen extending through the catheter adapter distal end and the catheter adapter proximal end. The catheter assembly may include a primary catheter extending from the catheter adapter distal end. The catheter delivery device may include a housing, which may include a housing distal end coupled to the catheter assembly, a housing proximal end, and a housing lumen extending through the housing distal end and the housing proximal end. A secondary catheter may be disposed within the housing. The secondary catheter may be configured to move distally through the catheter assembly in response to a fluid pressure provided by a fluid delivery device coupled to the housing proximal end.

Abstract: A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

Abstract: A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

Abstract: A catheter system may include a catheter assembly and a catheter delivery device. The catheter assembly may include a catheter adapter, which may include a catheter adapter distal end, a catheter adapter proximal end, and a catheter adapter lumen extending through the catheter adapter distal end and the catheter adapter proximal end. The catheter assembly may include a primary catheter extending from the catheter adapter distal end. The catheter delivery device may include a housing, which may include a housing distal end coupled to the catheter assembly, a housing proximal end, and a housing lumen extending through the housing distal end and the housing proximal end. A secondary catheter may be disposed within the housing. The secondary catheter may be configured to move distally through the catheter assembly in response to a fluid pressure provided by a fluid delivery device coupled to the housing proximal end.

Abstract: Systems and methods are provided for a computer-implemented method for identifying pairs of cohesive words within a text. A supervised model is trained to detect cohesive words within a text to be scored. Training the supervised model includes identifying a plurality of pairs of candidate cohesive words in a training essay and an order associated with the pairs of candidate cohesive words based on an order of words in the training essay. The pairs of candidate cohesive words are filtered to form a set of evaluation pairs. The evaluation pairs are provided via a graphical user interface based on the order associated with the pairs of candidate cohesive words. An indication of cohesion or no cohesion is received for the evaluation pairs via the graphical user interface. The supervised model is trained based on the evaluation pairs and the received indications.

Abstract: Systems and methods are provided for a computer-implemented method for identifying pairs of cohesive words within a text. A supervised model is trained to detect cohesive words within a text to be scored. Training the supervised model includes identifying a plurality of pairs of candidate cohesive words in a training essay and an order associated with the pairs of candidate cohesive words based on an order of words in the training essay. The pairs of candidate cohesive words are filtered to form a set of evaluation pairs. The evaluation pairs are provided via a graphical user interface based on the order associated with the pairs of candidate cohesive words. An indication of cohesion or no cohesion is received for the evaluation pairs via the graphical user interface. The supervised model is trained based on the evaluation pairs and the received indications.

Abstract: Systems and methods are provided for scoring a constructed response. The constructed response is processed according to a set of grammar rules to generate a data structure. The grammar rules specify a set of preferred responses for the item. The grammar rules utilize a plurality of variables that specify legitimate word patterns for the constructed response. It is determined whether the data structure indicates that the constructed response is included in the set of preferred responses, and if so, a maximum score is assigned to the constructed response. If the data structure indicates that the constructed response is not included in the set of preferred responses, a partial credit score for the constructed response is determined by assessing from the data structure which ones of the concepts represented by the variables are present in the constructed response. The partial credit score is assigned based on the presence of the concepts.

Abstract: The invention is an apparatus for forming an ultrasonic weld that includes a sonotrode having an ultrasonic actuator coupled to an elongate sealing end face for delivering ultrasonic energy to the webs in the sealing gap and a rotating cylindrical anvil having at least one raised portion extending longitudinally along an outer surface thereof. The raised portion has a radially outer surface, whereby the sealing gap is defined intermittently between the end face of the sonotrode and the radially outer surface of the raised portion of the anvil as the raised portion rotates past the end face of the sonotrode. The elongate sealing end face of the sonotrode has a substantially helical surface, whereby the sealing gap travels helically along the surface as the raised portion of the anvil cylinder rotates past the end face of the sonotrode.