Patents by Inventor Daniel Blankschtein
Daniel Blankschtein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220118170Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.Type: ApplicationFiled: October 28, 2021Publication date: April 21, 2022Applicants: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Carl Magnus SCHOELLHAMMER, Carlo Giovanni TRAVERSO, Avraham SCHROEDER, Baris POLAT, Daniel BLANKSCHTEIN, Robert S. LANGER, William BRUGGE
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Patent number: 11229892Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.Type: GrantFiled: February 25, 2019Date of Patent: January 25, 2022Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Patent number: 11185626Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.Type: GrantFiled: October 6, 2017Date of Patent: November 30, 2021Assignee: Massachusetts Institute of TechnologyInventors: Carl Magnus Schoellhammer, Carlo Giovanni Traverso, Avraham Schroeder, Baris Polat, Daniel Blankschtein, Robert S. Langer, William Brugge
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Patent number: 10814115Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.Type: GrantFiled: December 27, 2012Date of Patent: October 27, 2020Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATIONInventors: Carlo Giovanni Traverso, Avraham D. Schroeder, Baris Erinc Polat, Carl Magnus Schoellhammer, Daniel Blankschtein, Daniel G. Anderson, Robert S. Langer
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Publication number: 20190184356Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.Type: ApplicationFiled: February 25, 2019Publication date: June 20, 2019Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Patent number: 10252231Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.Type: GrantFiled: October 30, 2015Date of Patent: April 9, 2019Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Patent number: 10005058Abstract: The present invention generally relates to colloids and methods for changing the arrangement of droplet phases. In some embodiments, the colloids and methods comprise a plurality of droplets comprising two or more components, such that the two or more components can change arrangement of the components in the presence of an external stimulus. In some embodiments, the change in component arrangement is reversible. In certain embodiments, the change in component arrangement forms Janus droplets.Type: GrantFiled: October 30, 2015Date of Patent: June 26, 2018Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Publication number: 20180055991Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.Type: ApplicationFiled: October 6, 2017Publication date: March 1, 2018Inventors: Carl Magnus SCHOELLHAMMER, Carlo Giovanni TRAVERSO, Avraham SCHROEDER, Baris POLAT, Daniel BLANKSCHTEIN, Robert S. LANGER, William BRUGGE
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Publication number: 20160151756Abstract: The present invention generally relates to colloids and methods for changing the arrangement of droplet phases. In some embodiments, the colloids and methods comprise a plurality of droplets comprising two or more components, such that the two or more components can change arrangement of the components in the presence of an external stimulus. In some embodiments, the change in component arrangement is reversible. In certain embodiments, the change in component arrangement forms Janus droplets.Type: ApplicationFiled: October 30, 2015Publication date: June 2, 2016Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Publication number: 20160151753Abstract: The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.Type: ApplicationFiled: October 30, 2015Publication date: June 2, 2016Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Edmundo Daniel Blankschtein, Lauren Dell Zarzar, Vishnu Sresht, Ellen Sletten, Julia Ann Kalow
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Publication number: 20140228715Abstract: A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.Type: ApplicationFiled: May 14, 2012Publication date: August 14, 2014Applicants: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Avraham D. Schroeder, Carlo Giovanni Traverso, Baris E. Polat, Kathryn A. Whitehead, Daniel G. Anderson, Robert S. Langer, Jr., Carl Magnus Schoellhammer, Daniel Blankschtein
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Patent number: 6018678Abstract: Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).Type: GrantFiled: October 19, 1995Date of Patent: January 25, 2000Assignee: Massachusetts Institute of TechnologyInventors: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer
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Patent number: 6002961Abstract: Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).Type: GrantFiled: July 25, 1995Date of Patent: December 14, 1999Assignee: Massachusetts Institute of TechnologyInventors: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer
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Patent number: 5947921Abstract: Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by providing chemical enhancers which increase the solubility of the compound to be transported and/or lipid bilayer solubility, and/or additional driving forces for transport, such as mechanical or osmotic pressure, magnetic fields, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities and other forces or concentrations than that required if each means of enhancing transport is used individually.Type: GrantFiled: December 18, 1995Date of Patent: September 7, 1999Assignee: Massachusetts Institute of TechnologyInventors: Mark E. Johnson, Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer, Michael Pishko, Joseph Kost
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Patent number: 5814599Abstract: Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).Type: GrantFiled: August 4, 1995Date of Patent: September 29, 1998Assignee: Massachusetts Insitiute of TechnologyInventors: Samir S. Mitragotri, Daniel Blankschtein, Robert S. Langer
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Patent number: 5772888Abstract: The present invention provides a method, device and diagnostic kit for separating and/or concentrating an analyte from a mixture containing one or more contaminants according to size using a two-phase aqueous micellar system. The methods and devices are applicable to a wide range of analytes including environmental pollutants and biological materials. Conditions for optimizing size separation of analyte and contaminant are provided and include selection of a single surfactant type or surfactant mixture, surfactant concentration and composition, temperature, pH, salt type and concentration, and the addition of polymers. The separation or concentration efficiencies can be further enhanced by repeatedly generating the two-phase aqueous systems in a multi-stage operation. This invention can be used for removing viruses from proteins following fermentation processes, as well as for concentrating viruses for vaccine manufacturing or gene therapy.Type: GrantFiled: July 18, 1996Date of Patent: June 30, 1998Assignee: Massachusetts Institute of TechnologyInventors: Chia-Li Liu, Daniel Blankschtein