Abstract: Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in a desired cell, tissue and/or organ of interest while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbody™, that include an effector target binding domain specific for an effector target, and an address binding domain specific for an address target are described.

Abstract: Macromolecule compositions and related methods that effect targeted delivery of therapeutic agents to effector targets in a desired cell, tissue and/or organ of interest while minimizing or avoiding undesirable delivery to other cells, tissues or organs are provided. Compositions and methods related to macromolecules, such as an ANDbody™, that include an effector target binding domain specific for an effector target, and an address binding domain specific for an address target are described.

Abstract: A method for providing a model for a part of a vehicle includes selecting at least one operation state, selecting at least one possible fault type for the vehicle part, simulating vehicle part performance for the at least one operation state during the occurrence of the at least one possible fault type, for each simulation creating a representation of the vehicle part performance in which each representation is associated with at least one operating parameter value, and storing the at least one representation.

Abstract: A turbocompound unit includes a bearing housing and a turbine shaft being rotatably supported in the bearing housing, wherein one end of the turbine shaft is provided with a turbine wheel. The turbocompound unit further includes a diffuser duct in which the turbine wheel is arranged to rotate, an exhaust collector extending from the diffuser duct to an exhaust outlet, and a sealing arrangement positioned in the vicinity of the turbine wheel for preventing oil from escaping from the bearing housing to the diffuser duct. The exhaust collector forms part of a buffer gas duct that is arranged to supply exhaust gas from the exhaust collector to the sealing arrangement for pressurizing the sealing arrangement.

Abstract: A turbocompound unit includes a bearing housing and a turbine shaft being rotatably supported in the bearing housing, wherein one end of the turbine shaft is provided with a turbine wheel. The turbocompound unit further includes a diffuser duct in which the turbine wheel is arranged to rotate, an exhaust collector extending from the diffuser duct to an exhaust outlet, and a sealing arrangement positioned in the vicinity of the turbine wheel fir preventing oil from escaping from the bearing housing to the diffuser duct. The exhaust collector forms part of a butler gas duct that is arranged to supply exhaust gas from the exhaust collector to the sealing arrangement for pressurizing the sealing arrangement.

Abstract: A method for providing a model for a part of a vehicle includes selecting at least one operation state, selecting at least one possible fault type for the vehicle part, simulating vehicle part performance for the at least one operation state during the occurrence of the at least one possible fault type, for each simulation creating a representation of the vehicle part performance in which each representation is associated with at least one operating parameter value, and storing the at least one representation.