Abstract: The present disclosure provides, inter alia, a pharmaceutically acceptable oral dosage form comprising an ionically chargeable hydrogel and a protective coating for delivery of an ionically chargeable active agent to an intestinal site. Also provided are methods for treatment using the pharmaceutically acceptable oral dosage form disclosed herein.

Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.

Abstract: The present disclosure provides milk vesicles as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within or otherwise associated with the milk vesicles, methods of producing such milk vesicles and compositions thereof, as well as methods of delivering such milk vesicles and compositions to a specific patient tissue or organ. Also provided herein is a composition comprising milk vesicles, wherein the milk vesicles comprise a lipid membrane to which one or more proteins are associated, and wherein (a) a relative abundance of casein in the composition is less than about 40%, and/or (b) a relative abundance of lactoglobulin in the composition is less than about 25%.

Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.

Abstract: An oral dosage form provides a delivery structure having active agent delivery regions at an exterior surface of a body of super-porous hydrogel material, and a protective coating, for delivery of the active agent to an intestinal site.

Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.

Abstract: A pharmaceutically acceptable oral dosage form for delivery of an agent to an intestinal site has one or more active agent regions having an active agent to be delivered to the intestinal site, one or more drying agent regions having at least one drying agent therein capable of drying an area about the intestinal site, the one or more drying agent regions being separate from the one or more active agent regions, and a protective coating at least partially covering a surface of the form. The dosage form has a fluid uptake capacity as measured for the entire dosage form when immersed in a fluid media according to a Dosage Form Fluid Uptake Assay of at least about 20 g fluid per dosage form.

Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.

Abstract: A cranking device for use with a winch having a crankable shaft, the cranking device comprising an engagement member selectively engageable with an end of the crankable shaft in a loose fitting relationship such that the engagement member may be rotated relative to the shaft end, a handle fixed to the engagement member for cranking same, a locking mechanism provided with the engagement member for locking the engagement member onto the end of the crankable shaft in the loose fitting relationship such that the shaft may be cranked together with the engagement member under relatively low torque. Additionally, the engagement member is preferably formed as a socket having a plurality of spacer members provided on an inner surface thereof for engaging the shaft end when the socket is fitted thereover such that a gap is defined between an outer periphery of the shaft and an inner periphery of the socket.