Patents by Inventor Daniel Broek
Daniel Broek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100303726Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: June 10, 2010Publication date: December 2, 2010Applicant: CELLMATRIXInventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 7763247Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: GrantFiled: February 15, 2008Date of Patent: July 27, 2010Assignee: Cell Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 7763248Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: GrantFiled: May 8, 2008Date of Patent: July 27, 2010Assignee: Cell Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 7566770Abstract: The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: GrantFiled: July 14, 2006Date of Patent: July 28, 2009Assignee: Cell-Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20080260733Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: May 8, 2008Publication date: October 23, 2008Applicant: CELLMATRIXInventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20080233133Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: February 15, 2008Publication date: September 25, 2008Applicant: Cell Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 7390885Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: GrantFiled: December 6, 2001Date of Patent: June 24, 2008Assignee: Cell Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 7365167Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: GrantFiled: November 26, 2001Date of Patent: April 29, 2008Assignee: Cell Matrix, Inc.Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20080050388Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: December 6, 2001Publication date: February 28, 2008Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20070077199Abstract: The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: July 14, 2006Publication date: April 5, 2007Inventors: Jeffry Watkins, William Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20050271650Abstract: The invention features methods and compositions for inhibiting angiogenesis in a tissue or detecting angiogenesis using antagonists of denatured or proteolyzed forms of laminin.Type: ApplicationFiled: February 17, 2005Publication date: December 8, 2005Inventors: Bruce Freimark, Daniel Broek, Peter Brooks
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Publication number: 20040091482Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: November 26, 2001Publication date: May 13, 2004Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Publication number: 20030099655Abstract: The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.Type: ApplicationFiled: November 26, 2001Publication date: May 29, 2003Inventors: Jeffry D. Watkins, William D. Huse, Ying Tang, Daniel Broek, Peter Brooks
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Patent number: 4658966Abstract: The present invention provides a hanging file system for releasably suspending a plurality of relatively large flat pages of blueprints or the like in a hanging relationship to one another including a generally rectangular rack portion having a plurality of pins extending from the lower portion of a rear member of the rack. A binder has an aperture formed in one end for operatively engaging one of the pins and a hanger forming having a slotted channel for operatively receiving the front member of the rack therein for hangably supporting the binder and the plurality of pages contained therein from the rack. The outer front end portion of the binder contains a flared opening for guiding the pages into the channel and between the lower gripping jaws which are resiliently biased by the plastic material itself toward one another for clampably retaining the pages with the hollow channel of the binder.Type: GrantFiled: March 28, 1986Date of Patent: April 21, 1987Inventor: Daniel Broek