Abstract: Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

Abstract: A suture delivery device includes a base portion and a deployment portion extending from the base portion. The base portion defines a longitudinal axis. The deployment portion includes a plurality of petals extending along the longitudinal axis parallel to one another when the deployment portion is in a delivery position and extending radially outward from the longitudinal axis when the deployment portion is in a deployed position.

Abstract: A tissue fixation device includes an elongated body extending between a proximal portion and a distal portion including a plurality of barbed loops. The elongated body, proximal portion, and distal portion are provided in a variety of configurations depending upon the performance requirements desired of the tissue fixation device for the envisaged application of use.

Abstract: The present disclosure relates to implantable medical devices which include a film which includes predetermined folding characteristics via predetermined thicknesses along different areas of the implant.

Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.

Abstract: A tissue fixation device includes an elongated body defining a longitudinal axis and including a proximal end and a distal end. At least two barbed segments diverge distally away from the distal end of the elongated body and a pledget is disposed at distal ends of the barbed segments. The elongated body, barbed segments, and pledget are provided in a variety of configurations depending upon the performance requirements desired of the tissue fixation device for the envisaged application of use.

Abstract: A tissue fixation device includes an elongated body extending between a distal portion including a barbed loop, and a proximal portion including a blunt tip. The elongated body, proximal portion, and distal portion are provided in a variety of configurations depending upon the performance requirements desired of the tissue fixation device for the envisaged application of use.

Abstract: A suture delivery device includes a base portion and a deployment portion extending from the base portion. The base portion defines a longitudinal axis.

Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.

Abstract: Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

Abstract: Oral dosage forms for the delivery of therapeutic agents include mechanical fasteners for engaging tissue of the gastrointestinal tract.

Abstract: The present disclosure relates to implantable medical devices which include at least one mesh and at least one film pivotably attached to the mesh.

Abstract: A medical device includes a substrate having at least one surface. The surface has a central portion and a peripheral portion. At least one bioactive agent is disposed over at least a portion of the surface. The medical device having a concentration gradient of the at least one bioactive between the central and peripheral portions.

Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.

Abstract: The present disclosure relates to self-detachable medical devices containing a detachable film layer and polymeric film layer.

Abstract: The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one aperture between the mesh and the film.

Abstract: The present disclosure relates to a medical device and methods of making the same. The medical device includes a porous substrate and at least one film. The film is formed within the pore of the substrate. The film is intra-porous and does not contact adjacent pores or films.

Abstract: A method of closing a thoracic incision includes providing a barbed suture and threading the suture around first and second ribs of a chest wall in a generally S-shaped configuration to close an incision positioned therebetween. The barbed suture is threaded through the chest wall by introducing the barbed suture through a first terminal tissue layer and around a surface of the first rib that is facing a second terminal tissue layer, passing the barbed suture across the incision and around a surface of the second rib that is facing the first terminal tissue layer, and withdrawing the barbed suture through the second terminal tissue layer. A second barbed suture may be threaded through the chest wall in a complementary S-shaped configuration in which the second barbed suture enters and exits the chest wall through the opposing terminal tissue layer from that of the first barbed suture.

Abstract: The present disclosure relates to implantable medical devices which include at least one mesh and at least one film attached to the mesh along different portions of the mesh creating at least one aperture between the mesh and the film.

Abstract: Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact with a mesh. The first therapeutic agent may be released at a first rate and the second therapeutic agent may be released at a second rate.