Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Liquid filter assemblies, features, components and methods are described. In general, a liquid filter cartridge is provided which includes features that help ensure that when the assembly is serviced, the cartridge positioned within the assembly is a proper one, in proper sealing orientation, for appropriate use. Features that can be used to provide for this include: a seal on the filter cartridge that defines a seal pattern non-orthogonal to a plane perpendicular to a central axis of the filter cartridge; and, a member of a projection/receiver arrangement on the filter cartridge which is orientated to engage a portion of a liquid filter assembly, for example a liquid flow collar, to allow sealing when the cartridge is a properly positioned cartridge and a properly configured cartridge. Assembly features are described. Also, a flexible radial projection arrangement providing snap-fit interaction between a cartridge and housing is provided. Methods of assembly and use as described.

Abstract: A computer-implemented method of generating a security language query from a user input query includes receiving, at a computer system, an input security hunting user query indicating a user intention; selecting, using a trained machine learning model and based on the input security hunting query, an example user security hunting query and corresponding example security language query; generating, using the trained machine learning model, query metadata from the input security hunting query; generating a prompt, the prompt comprising: the input security hunting user query; the selected example user security hunting query and the corresponding example security language query; and the generated query metadata; inputting the prompt to a large language model; receiving a security language query from the large language model corresponding to the input security hunting query reflective of the user intention.

Abstract: An exemplary unmanned aerial vehicle (UAV) mountable to a conductor of an aerial power transmission line system includes a body having a rotor system, a motivation system attached to the body to motivate the UAV along the conductor, a battery carried by the body and electrically connected to at least one of the rotor system and the motivation system, a monitoring tool mounted with the body and an inductive coil carried by the body and in electric connection with the battery, wherein the inductive coil is configured to harvest electricity from the aerial power transmission line system and charge the battery.

Abstract: A versatile door system for a vehicle having a frame with an opening. The door system includes a door assembly including a hingeable door and a slidable door. The hingeable door is hingeably coupled to the frame proximate the opening. The slidable door is slidably coupled to the hingeable door. A rail system includes a segmented upper rail having a first portion coupled to the frame and a second portion formed on an exterior side of the hingeable door. The slidable door includes a slider bearing configured to sequentially engage the first and second portions of the segmented upper rail along a path of travel of the slidable door. In a closed configuration, the hingeable door and the slidable door are securably disposed within the opening. The hingeable door and the slidable door are configured to collectively provide access to selectable portions of the opening.

Abstract: A ducted fan assembly includes a duct having an inlet, an inner surface, an expanding diffuser and an outlet. A fan disposed within the duct between the inlet and the expanding diffuser is configured to rotate about a fan axis to generate airflow. An active flow control system includes a plurality of injection zones circumferentially distributed about the inner surface. The expanding diffuser has a diffuser angle configured to create flow separation when the airflow is uninfluenced by the active flow control system such that the airflow has a thrust vector with a first direction that is substantially parallel to the fan axis. Injection of pressurized air from one of the injection zones asymmetrically reduces the flow separation between the airflow and the expanding diffuser downstream of that injection zone such that the thrust vector of the airflow has a second direction that is not parallel to the first direction.

Abstract: An exemplary unmanned aerial vehicle (UAV) mountable to a conductor of an aerial power transmission line system includes a body having a rotor system, a motivation system attached to the body to motivate the UAV along the conductor, a battery carried by the body and electrically connected to at least one of the rotor system and the motivation system, a monitoring tool mounted with the body and an inductive coil carried by the body and in electric connection with the battery, wherein the inductive coil is configured to harvest electricity from the aerial power transmission line system and charge the battery.

Abstract: Systems and methods for generating database schema change documents based on a data model and model changes indicated by a user. Information items related to one or more objects defined in the data model are received, and user input regarding changed objects is requested. In embodiments, changes are evaluated against configurable design criteria. One or more human and/or machine readable database schema change documents, and are stored in memory. Design criteria and change documents can vary based on a target database platform in embodiments.

Abstract: An exemplary unmanned aerial vehicle (UAV) mountable to a conductor of an aerial power transmission line system includes a body having a rotor system, a motivation system attached to the body to motivate the UAV along the conductor, a battery carried by the body and electrically connected to at least one of the rotor system and the motivation system, a monitoring tool mounted with the body and an inductive coil carried by the body and in electric connection with the battery, wherein the inductive coil is configured to harvest electricity from the aerial power transmission line system and charge the battery.

Abstract: A differential thrust vectoring system includes a first thruster, a second thruster, a main actuator, and a trim actuator. The system is configured such that actuation of the main actuator causes rotation of the thrusters together about an axis, whereas actuation of the trim actuator causes relative rotation of the first and second thrusters about the axis.

Abstract: Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein.

Abstract: A tail sitter aircraft includes a fuselage having a forward portion, an aft portion and a longitudinally extending fuselage axis. At least two wings are supported by the forward portion of the fuselage. A distributed propulsion system includes at least one propulsion assembly operably associated with each fixed wing and is operable to provide forward thrust during forward flight and vertical thrust during vertical takeoff, hover and vertical landing. A tailboom assembly extends from the aft portion of the fuselage and includes a plurality of rotatably mounted tail arms having control surfaces and landing members. In a forward flight configuration, the tail arms are radially retracted to reduce tail surface geometry and provide yaw and pitch control with the control surfaces. In a landing configuration, the tail arms are radially extended relative to the fuselage axis to form a stable ground contact base with the landing members.

Abstract: Methods and systems for designing, testing, and validating genome designs based on rules or constraints or conditions or parameters or features and scoring are described herein.

Abstract: A differential thrust vectoring system including a first thruster rotation assembly configured to rotate a first thruster relative of an aircraft, a second thruster rotation assembly configured to rotate a second thruster of an aircraft, and an actuator. The system is configured such that actuation of the actuator causes disparate rotation about the tilt axis of the first and second thrusters.

Abstract: A vehicle has a pod carrier, a pod rotatably connected to the pod carrier, and an energy attenuating system (EAS) disposed between the pod and the pod carrier to attenuate forces associated with a deflection of the pod relative to the pod carrier. A method of operating an energy attenuating system (EAS) is provided for attenuating energy associated with movement between a pod and a pod carrier. The method includes providing a vehicle having a pod carrier and providing the pod carrier with an EAS configured in an undeflected state.

Abstract: A ducted fan assembly for generating thrust during edgewise forward flight. The ducted fan assembly includes a duct having an inlet with a leading portion and a diffuser with a trailing portion during the edgewise forward flight. A fan disposed within the duct is configured to rotate relative to the duct about a fan axis to generate an airflow through the duct from the inlet to the diffuser. An active flow control system includes a plurality of injectors including a first injector configured to inject pressurized air substantially tangential with the leading portion of the inlet and a second injector configured to inject pressurized air substantially tangential with the trailing portion of the diffuser such that when the injectors are injecting pressurized air, flow separation of the airflow at the leading portion of the inlet and the trailing portion of the diffuser is reduced.

Abstract: A versatile door system for a vehicle having a frame with an opening. The door system includes a door assembly including a hingeable door and a slidable door. The hingeable door is hingeably coupled to the frame proximate the opening. The slidable door is slidably coupled to the hingeable door. A rail system includes a segmented upper rail having a first portion coupled to the frame and a second portion formed on an exterior side of the hingeable door. The slidable door includes a slider bearing configured to sequentially engage the first and second portions of the segmented upper rail along a path of travel of the slidable door. In a closed configuration, the hingeable door and the slidable door are securably disposed within the opening. The hingeable door and the slidable door are configured to collectively provide access to selectable portions of the opening.

Abstract: An active flow control system for generating yaw control moments for an aircraft during hover flight. The system includes right and left yaw effectors disposed proximate the right and left wingtips of the wing. A pressurized air system includes a pressurized air source and a plurality of injectors operably associated with the right and left yaw effectors. Based upon which of the injectors is injecting pressurized air, the right and left yaw effectors generate no yaw control moment, generate a yaw right control moment or generate a yaw left control moment.

Abstract: A versatile door system for an aircraft includes forward and aft door assemblies. The forward door assembly includes a forward hingeable door hingeably coupled to the airframe proximate a forward location of an aircraft opening and a forward slidable door slidably coupled to the forward hingeable door. The aft door assembly includes an aft hingeable door hingeably coupled to the airframe proximate an aft location of the aircraft opening and an aft slidable door slidably coupled to the aft hingeable door. In a closed configuration, the forward hingeable door, the forward slidable door, the aft hingeable door and the aft slidable door are securably disposed within the aircraft opening. In operation, the forward hingeable door, the forward slidable door, the aft hingeable door and the aft slidable door are individually operable to collectively provide access to a selectable width of the aircraft opening.