Patents by Inventor Daniel Bucheli

Daniel Bucheli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND DEVICES FOR PRODUCING BIOMOLECULES
    Publication number: 20150307911
    Abstract: A scalable process and device for producing a bio molecule, in particular pharmaceutical grade plasmid DNA is described. The process includes the steps of alkaline lysis, neutralization and clarification and can be further extended. For separating the lysate and the precipitate an improved floatation method is disclosed. This method is based on attachment of CO2 bubbles on the precipitate floe. The CO2 is released from a carbonate salt during or after neutralization (acidification). The method of the invention is preferably carried out in an automated continuous mode applying devices for lysis and neutralization and a novel device for completely continuous clarification (separation of floes and clarified lysate).
    Type: Application
    Filed: July 8, 2015
    Publication date: October 29, 2015
    Inventors: Jochen URTHALER, Christine ASCHER, Daniel BUCHELI
  • METHODS AND DEVICES FOR PRODUCING BIOMOLECULES
    Publication number: 20140154747
    Abstract: A scalable process and device for producing a bio molecule, in particular pharmaceutical grade plasmid DNA is described. The process includes the steps of alkaline lysis, neutralization and clarification and can be further extended. For separating the lysate and the precipitate an improved floatation method is disclosed. This method is based on attachment of CO2 bubbles on the precipitate floe. The CO2 is released from a carbonate salt during or after neutralization (acidification). The method of the invention is preferably carried out in an automated continuous mode applying devices for lysis and neutralization and a novel device for completely continuous clarification (separation of flocs and clarified lysate).
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Applicant: Boehringer Ingelheim RCV GmbH & Co. KG
    Inventors: Jochen URTHALER, Christine ASCHER, Daniel BUCHELI
  • METHODS AND DEVICES FOR PRODUCING BIOMOLECULES
    Publication number: 20110124101
    Abstract: A scalable process and device for producing a bio molecule, in particular pharmaceutical grade plasmid DNA is described. The process includes the steps of alkaline lysis, neutralization and clarification and can be further extended. For separating the lysate and the precipitate an improved floatation method is disclosed. This method is based on attachment of CO2 bubbles on the precipitate floe. The CO2 is released from a carbonate salt during or after neutralization (acidification). The method of the invention is preferably carried out in an automated continuous mode applying devices for lysis and neutralization and a novel device for completely continuous clarification (separation of floes and clarified lysate).
    Type: Application
    Filed: February 6, 2009
    Publication date: May 26, 2011
    Applicant: BOEHRINGER INGELHEIM RCV GMBH & CO. KG
    Inventors: Jochen Urthaler, Christine Ascher, Daniel Bucheli