Patents by Inventor Daniel Bur

Daniel Bur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tropane derivatives and their use as ace inhibitors
    Publication number: 20060205768
    Abstract: The invention relates to novel tropane derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 14, 2006
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller, Thierry Sifferlen
  • Novel tetrahydropyridine derivatives as renin inhibitors
    Publication number: 20060009497
    Abstract: The invention relates to novel tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
    Type: Application
    Filed: April 29, 2003
    Publication date: January 12, 2006
    Applicant: ACTELION PHARMACEUTICALS, LTD.
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Thomas Weller
  • 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases
    Publication number: 20050176700
    Abstract: The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
    Type: Application
    Filed: April 8, 2003
    Publication date: August 11, 2005
    Inventors: Olivier Bezencon, Daniel Bur, Walter Fischli, Lubos Remen, Sylvia Richard-Bildstein, Hans-Peter Weber, Thomas Weller
  • Pyrrolidine derivatives
    Publication number: 20040242672
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Application
    Filed: June 30, 2004
    Publication date: December 2, 2004
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Ulrike Obst, Hans Peter Wessel
  • Pyrrolidine derivatives
    Patent number: 6790860
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: September 14, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Ulrike Obst, Hans Peter Wessel
  • Pyrrolidine derivatives
    Patent number: 6660738
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: December 9, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow
  • Pyrrolidine derivatives
    Publication number: 20030199569
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Application
    Filed: February 25, 2003
    Publication date: October 23, 2003
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Ulrike Obst, Hans Peter Wessel
  • Pyrrolidine derivatives
    Patent number: 6541638
    Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: April 1, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Johannes Aebi, Denise Blum, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Bernd Michael Loeffler, Ulrike Obst, Sabine Wallbaum
  • Pyrrolidine derivatives
    Publication number: 20020055632
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Application
    Filed: July 17, 2001
    Publication date: May 9, 2002
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow
  • Pyrrolidine derivatives
    Publication number: 20020049243
    Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
    Type: Application
    Filed: July 17, 2001
    Publication date: April 25, 2002
    Inventors: Johannes Aebi, Denise Blum, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Bernd Michael Loeffler, Ulrike Obst, Sabine Wallbaum
  • Pyrrolidine derivatives
    Publication number: 20020040146
    Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
    Type: Application
    Filed: July 17, 2001
    Publication date: April 4, 2002
    Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Ulrike Obst, Hans Peter Wessel
  • Piperidine derivatives
    Patent number: 6197959
    Abstract: Compounds of formula (I) wherein R1 and R2 are as defined in the description and claims and pharmaceutically acceptable salts thereof, are useful for the treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, for example, cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: March 6, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Volker Breu, Daniel Bur, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl
  • Piperidine derivative having renin inhibiting activity
    Patent number: 6150526
    Abstract: Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: November 21, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl
  • Piperidine derivatives having renin inhibiting activity
    Patent number: 6051712
    Abstract: Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: April 18, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl