Abstract: A method of predicting a patient's prognosis of prostate cancer, the method comprising providing and analysing a patients germline genetic material and detecting germline variants of genes up-regulated by activation of the PI3K/AKT/mTOR pathway, genes up-regulated by activation of the PI3K/AKT/mTOR pathway, genes up-regulated by KRAS activation, genes up-regulated in response to low oxygen levels, genes regulated by NF-kB in response to tumour necrosis factor (TNF) and/or genes specifically up-regulated in pancreatic beta cells or at least one gene from Table 1. Also provided is a method of determining treatment regimen and a biomarker panel.

Abstract: A method of generating an annual product quality review report includes defining at least one author for generating the report; selecting a chapter for inclusion in the report, wherein the chapter is associated with one or more predefined data requirements which predefined data requirements may be presented to the author for inclusion in the report; defining at least one system of record from a plurality of systems of record as a source of raw data for providing data to the one or more predefined data requirements. The at least one system of record provides raw data to the predefined data requirements through a tech fabric that causes the raw data to populate one or more enterprise object models to standardize the raw data.

Abstract: Systems, apparatuses, methods, and computer program products are provided herein. For example, the method includes identifying production data representative of an object process and an object. In some embodiments, the object process comprises a plurality of subsidiary object processes. In some embodiments, the method includes generating an object process state representation template using the production data. In some embodiments, the method includes, from at least one of the plurality of processing systems, operational data. In some embodiments, the method includes the operational data to determine an object process state. In some embodiments, processing the operational data comprises applying the operational data to an object process state model. In some embodiments, the method includes generating an object process state representation in response to determining the object process state.

Abstract: A method of generating an annual product quality review report includes defining at least one author for generating the report; selecting a chapter for inclusion in the report, wherein the chapter is associated with one or more predefined data requirements which predefined data requirements may be presented to the author for inclusion in the report; defining at least one system of record from a plurality of systems of record as a source of raw data for providing data to the one or more predefined data requirements. The at least one system of record provides raw data to the predefined data requirements through a tech fabric that causes the raw data to populate one or more enterprise object models to standardize the raw data.

Abstract: Systems and methods for a vapor compression system including primary actuators, secondary actuators, primary sensors that provide a primary set of system outputs, and secondary sensors that provide a secondary set of system outputs. A primary controller receives the primary set of system outputs, and produces a primary set of control inputs for the primary actuators, to regulate one or more zone temperatures to set-points and to regulate one or more critical process variables to set-points. A secondary controller receives the secondary set of system outputs, and produces a secondary set of control inputs, to minimize an overall system power consumption. The secondary inputs may include set-points to the primary controller. The primary outputs may include estimates of critical process variables that are used as inputs to the secondary controller.

Abstract: Systems and methods for a vapor compression system including primary actuators, secondary actuators, primary sensors that provide a primary set of system outputs, and secondary sensors that provide a secondary set of system outputs. A primary controller receives the primary set of system outputs, and produces a primary set of control inputs for the primary actuators, to regulate one or more zone temperatures to set-points and to regulate one or more critical process variables to set-points. A secondary controller receives the secondary set of system outputs, and produces a secondary set of control inputs, to minimize an overall system power consumption. The secondary inputs may include set-points to the primary controller. The primary outputs may include estimates of critical process variables that are used as inputs to the secondary controller.

Abstract: A controller controls a first air-conditioning system and a second air-conditioning system having separate refrigerant circuits, but arranged for conditioning a common space. The controller includes a multi-variable regulator to determine control signals for controlling operations of first components of the first and the second refrigerant circuits to reduce jointly and concurrently an environmental error between setpoint and measured values of environment in the common space. The controller also includes at least two single-variable regulators to receive operational errors between setpoint and measured values of an operation of a second component of the first and the second refrigerant circuits. The controller separately determines control signals for controlling the operation of different refrigerant circuits that reduce the operational errors.

Abstract: A controller controls a first air-conditioning system and a second air-conditioning system having separate refrigerant circuits, but arranged for conditioning a common space. The controller includes a multi-variable regulator to determine control signals for controlling operations of first components of the first and the second refrigerant circuits to reduce jointly and concurrently an environmental error between setpoint and measured values of environment in the common space. The controller also includes at least two single-variable regulators to receive operational errors between setpoint and measured values of an operation of a second component of the first and the second refrigerant circuits. The controller separately determines control signals for controlling the operation of different refrigerant circuits that reduce the operational errors.

Abstract: A method for controlling a vapor compression system determines a value of a metric of performance of the vapor compression system using a previous value of an estimated parameter and a previous value of a control signal determined for a previous time step of the control. The values of the estimated parameter represent a relationship between values of the control signal and values of the metric of performance. A current value of the estimated parameter is determined based on the previous value of the estimated parameter and an error between the determined value of the metric of performance and a measured value of the metric of performance. Next, a current value of the control signal is determined based on the current value of the estimated parameter.

Abstract: A method of assembling a core stiffened structure that includes bonding a composite core to a substructure by utilizing magnetic force to create pressure between a flat surface of the composite core the substructure, and bonding a face sheet onto a surface network of the composite core.

Abstract: A method for controlling a vapor compression system determines a value of a metric of performance of the vapor compression system using a previous value of an estimated parameter and a previous value of a control signal determined for a previous time step of the control. The values of the estimated parameter represent a relationship between values of the control signal and values of the metric of performance. A current value of the estimated parameter is determined based on the previous value of the estimated parameter and an error between the determined value of the metric of performance and a measured value of the metric of performance. Next, a current value of the control signal is determined based on the current value of the estimated parameter.

Abstract: A method of assembling a core stiffened structure that includes bonding a composite core to a substructure by utilizing magnetic force to create pressure between a flat surface of the composite core the substructure, and bonding a face sheet onto a surface network of the composite core.

Abstract: A hemostatic agent comprises diatomaceous earth in particle form. Devices for promoting hemostasis comprise diatomaceous earth in particle form and a receptacle for retaining the particles therein. The receptacle is defined by a mesh having openings therein. A hemostatic sponge comprises a substrate, diatomaceous earth disposed on the substrate, and a release agent disposed on the substrate. A hemostatic sponge may also comprise a film into which diatomaceous earth is incorporated, or it may comprise a substrate, diatomaceous earth disposed on the substrate, and a film disposed over the diatomaceous earth. A hemostatic sponge may also comprise a first substrate, diatomaceous earth disposed on the first substrate, and a second substrate disposed on the diatomaceous earth. When treating a bleeding wound using any of the foregoing devices, application of the device causes the diatomaceous earth to come into contact with blood to cause a clotting effect.

Abstract: A digital wireless intercom system provides voice communications between selected mobile user stations via allocated radio channels. All communications flow via channels between the mobile stations and the base station. The base station includes a crosspoint processor for setting up desired communication links between users. A data store contains data identifying the preferences of each user, including the other users with whom communication links are to be set up. On receipt of a user ID from a mobile station, a correlator in the base station correlates the particular user with the channel being used by the mobile station of the user, so that the crosspoint processor can identify the channels in use for setting up the required communication links. The correlator dynamically updates the channel allocations as channels used by any particular user change. In this way, the crosspoint processor seamlessly follows channel changes, maintaining the required communication links with particular users.

Abstract: The present invention concerns a vehicle seat having an opposingly located seat frame and located base. A dampener is connected to and disposed between the seat frame and the base. The invention includes at least one flexible anchor for coupling the seat frame to a point on the seat which is lower than the seat frame. In addition, a portion of said seat frame may be made of a light weight material such as magnesium.

Abstract: A digital wireless intercom system provides voice communications between selected mobile user stations via allocated radio channels. All communications flow via channels between the mobile stations and the base station. The base station includes a crosspoint processor for setting up desired communication links between users. A data store contains data identifying the preferences of each user, including the other users with whom communication links are to be set up. On receipt of a user ID from a mobile station, a correlator in the base station correlates the particular user with the channel being used by the mobile station of the user, so that the crosspoint processor can identify the channels in use for setting up the required communication links. The correlator dynamically updates the channel allocations as channels used by any particular user change. In this way, the crosspoint processor seamlessly follows channel changes, maintaining the required communication links with particular users.

Abstract: A triangular-shaped portable collapsible stand to accommodate either sheet music or books. It is a three-piece stand is designed for table top use. It is assembled by sliding angled slots into grooves.

Abstract: Control logic and a method for controlling turbine speed. In an embodiment, the inventive control logic controls turbine speed of turbine generators operating in a stand-alone mode and/or a grid mode.

Abstract: A portable marker and retriever assembly is designed to be attached to a snowmobile or some similar vehicle. In one application, the assembly releases a tethered float in that situation when the snow mobile breaks through ice and sinks below the surface of a body of water. In another situation, the tether can be attached from one snowmobile to another to facilitate a towing operation.

Abstract: A memory cell is provided comprising a bistable latch (I1, I2) having first and second nodes (NODE 1, NODE 2) and a nonvolatile transistor (NV1). The control gate of the nonvolatile transistor is connected to the first node and either the source or drain is connected to the second node. A switching transistor is provided for maintaining the control gate and the substrate of the nonvolatile transistor at substantially the same potential during volatile operation of the latch, thereby reducing voltage stress which would lead to charge tunnelling to or from the floating gate. In this way, disturbance of the floating gate charge is avoided during volatile operation. The cell is particularly suited to silicon gate fabrication technology.