Patents by Inventor Daniel BYGRAVE

Daniel BYGRAVE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING DOUBLE STRANDED POLYNUCLEOTIDES BASED ON OLIGONUCLEOTIDES WITH SELECTED AND DIFFERENT MELTING TEMPERATURES
    Publication number: 20210139957
    Abstract: A method for identifying a group of single-stranded oligonucleotides for self-assembly into a double-stranded polynucleotide, the group comprising a plurality of overlapping complementary oligonucleotides, wherein each overlap between complementary oligonucleotides is selected to have a melting temperature (Tm) that differs from the melting temperatures of all other overlapping complementary oligonucleotides in the group.
    Type: Application
    Filed: March 13, 2018
    Publication date: May 13, 2021
    Inventors: Joseph BRENNAN, Daniel BYGRAVE, Sangeeta ADITYA, Raquel SANCHES-KUIPER
  • OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS
    Publication number: 20210047361
    Abstract: The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XNA, wherein the process comprises thermally controlled deprotection steps at the 5?-OH of previously coupled nucleosides or nucleotides at selected sites on the surface of the substrate.
    Type: Application
    Filed: January 23, 2019
    Publication date: February 18, 2021
    Inventors: Stuart CROSBY, Mathew JENISON, Joseph BRENNAN, Iain BARLOW, Pascal LANG, Matthew HAYES, Catherine FITZPATRICK, Daniel BYGRAVE