Patents by Inventor Daniel C. Capaldi

Daniel C. Capaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF OLIGOMERIC COMPOUNDS COMPRISING PHOSPHOROTHIOATE DIESTER AND PHOSPHODIESTER LINKAGES
    Publication number: 20220251128
    Abstract: The present disclosure provides methods for synthesizing oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage. In certain embodiments, the present disclosure provides oxidation reagents that produce low amounts of unwanted phosphate diester impurities in oligomeric compounds having at least one phosphorothioate diester linkage and at least one phosphate diester internucleoside linkage.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 11, 2022
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Andrew K. McPherson, Andrew A. Rodriguez, Daniel C. Capaldi
  • Chloral-free DCA in oligonucleotide synthesis
    Patent number: 7759480
    Abstract: A process of manufacturing oligonucleotides includes a 5?-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: July 20, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Achim Krotz, Daniel C. Capaldi, Hans-Joachim Josef Gaus, Brett Turney
  • Methods for detection of chloral hydrate in dichloroacetic acid
    Patent number: 7446193
    Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: November 4, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Patrick Wheeler, Daniel C. Capaldi
  • Compounds and methods for the characterization of oligonucleotides
    Patent number: 7427675
    Abstract: The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: September 23, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Daniel C. Capaldi, Hans-Joachim Josef Gaus, Claus Andre Frank Rentel, Philip Dmitri Olsen, Christine C. Kurata, Quanlai Song
  • Process for the synthesis of oligomeric compounds
    Patent number: 7227016
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: June 5, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7199236
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: April 3, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7186822
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: March 6, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei P. Guzaev
  • Methods for detection of chloral hydrate in dichloroacetic acid
    Patent number: 7173123
    Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: February 6, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Patrick Wheeler, Daniel C. Capaldi
  • Process for the synthesis of oligomeric compounds
    Patent number: 7041816
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: May 9, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligomer phosphoramidite compositions and processes for synthesizing the same
    Patent number: 6858722
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 22, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6858715
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20040219577
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: January 20, 2004
    Publication date: November 4, 2004
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligomer phosphoramidite compositions and processes for synthesizing the same
    Publication number: 20030229220
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Application
    Filed: May 23, 2003
    Publication date: December 11, 2003
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the preparation of oligonucleotide compounds
    Patent number: 6649750
    Abstract: Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: November 18, 2003
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole
  • Methods for detection of chloral hydrate in dichloroacetic acid
    Patent number: 6645716
    Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: November 11, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Patrick Wheeler, Daniel C. Capaldi
  • Processes for the synthesis of oligomers using phosphoramidite compositions
    Patent number: 6610842
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: August 26, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030088088
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 6465628
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: October 15, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Methods for detection of chloral hydrate in dichloroacetic acid
    Publication number: 20020119483
    Abstract: Methods for detecting chloral hydrate in dichloroacetic acid are described.
    Type: Application
    Filed: January 29, 2002
    Publication date: August 29, 2002
    Inventors: Patrick Wheeler, Daniel C. Capaldi
  • Reagent useful for synthesizing sulfurized oligonucleotide analogs
    Patent number: 6399831
    Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole, Daniel C. Capaldi