Abstract: A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec10 gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided.

Abstract: A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec10 gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided.

Abstract: A method of treating an article made of a fluoropolymer such as PTFE and, in particular, expanded PTFE (ePTFE), to provide a hydrophilic surface characteristic to the article. A filler is dispersed in a solvent and combined with PTFE to form a paste, which is extruded to form a shaped article and then expanded to form a porous ePTFE article, such as a tubular filter, for example, that includes filler particles dispersed and embedded within the bulk ePTFE. Functional groups of at least some of the filler particles are exposed at the surfaces or within the pores of the ePTFE article, which serve as reaction sites for a hydrophilic treatment by which hydrophilic molecules are chemically bound to the filler particles to thereby provide the surface and/or pores of the ePTFE article with a hydrophilic characteristic.

Abstract: A fluoropolymer coating that includes nanoparticles for providing the coating with improved release characteristics together with improved abrasion resistance. In one embodiment, the nanoparticles are silica particles that may be incorporated into the coating by adding colloidal silica to the liquid coating formulation that is applied to a substrate, typically over a primer, and then cured. After the coating is cured, the coating demonstrates enhanced release characteristics together with improved abrasion resistance. It has been unexpectedly observed that a combination of desired release characteristics and improved abrasion resistance is found when the average particle size of the nanoparticles is between 30 and 120 nm, with the abrasion resistance generally increasing with increasing particle size.

Abstract: A shatter containment coating composition for glass substrates, such as the glass tubing of compact fluorescent light bulbs If the light bulb breaks or shatters, the coating aids in containing shattered glass fragments of the light bulb, as well as gases and other elements within the light bulb, to thereby aid in disposal of the light bulb and/or to prevent the escape of gases or other elements into the environment The coating may be provided in the form of an aqueous dispersion having a relatively low viscosity such that, when coated onto a glass surface having complex geometry, such as the tubing of a compact fluorescent light bulb for example, the coating can conform to the surfaces having the complex geometry The coating may be a modified polyolefin provided in one or more layers, including a base coat, and the coating may be cured to form a film at a temperature of less than 150 C.

Abstract: The present invention is directed to a combination therapy for inhibiting angiogenesis in a subject having, or at risk of having, an angiogenic disease/disorder. The method comprises both administering to the mammal an inhibitor of HIF-I and administering a second compound or agent that inhibits angiogenesis such as an inhibitor of IL-8, VEGF, angiopoietins, EGF, FGF, TGF, G-CSF, or PDGF. Administration of an inhibitor of hypoxia inducible factor-1 (HIF-I) in combination with an inhibitor of interleukin 8 (IL-8) is particularly useful for treatment of colon cancer, lung cancer, pancreatic cancer, and breast cancer.

Abstract: Single coat coating systems (22), as well as articles coated with such non-stick coating systems, are provided. The single coat system includes a fluoropolymer copolymer (14a), such as fluoropolymer terpolymer including tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride monomers, with fluoropolymer copolymers are referred to collectively as THV. The single coat system exhibits excellent substrates adhesion and release properties, is resistant to separation failure at the interface between the binder (12) and fluoropolymer components (14a), and exhibits adhesion to smooth substrates (16). The single coat system may also include a high level of fillers to provide increased damage resistance without compromising the above benefits.

Abstract: Multiple coat non-stick coating systems, as well as articles coated with such non-stick coating systems, are provided. The primer (22a) of the multiple coat system includes a fluoropolymer (14a) copolymer, such as a fluoropolymer terpolymer including tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride monomers, which fluoropolymer copolymers are referred to collectively as THV. The multiple coat system exhibits excellent substrate adhesion and release properties, and the primer exhibits excellent primer-substrate adhesion and primer-topcoat adhesion. The multiple coat system is additionally resistant to separation failure at the interface between the binder (12) and fluoropolymer components of the primer, exhibits excellent adhesion to smooth substrates (16), and may also include a high level of fillers to provide increased damage resistance without compromising the above benefits.

Abstract: Single coat coating systems (22), as well as articles coated with such non-stick coating systems, are provided. The single coat system includes a fluoropolymer copolymer (14a), such as a fluoropolymer terpolymer including tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride monomers, which fluoropolymer copolymers are referred to collectively as THV. The single coat system exhibits excellent substrate adhesion and release properties, is resistant to separation failure at the interface between the binder (12) and fluoropolymer components (14a), and exhibits excellent adhesion to smooth substrates (16). The single coat system may also include a high level of fillers to provide increased damage resistance without compromising the above benefits.

Abstract: Multiple coat non-stick coating systems, as well as articles coated with such non-stick coating systems, are provided. The primer (22a) of the multiple coat system includes a fluoropolymer (14a) copolymer, such as a fluoropolymer terpolymer including tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride monomers, which fluoropolymer copolymers are referred to collectively as THV. The multiple coat system exhibits excellent substrate adhesion and release properties, and the primer exhibits excellent primer-substrate adhesion and primer-topcoat adhesion. The multiple coat system is additionally resistant to separation failure at the interface between the binder (12) and fluoropolymer components of the primer, exhibits excellent adhesion to smooth substrates (16) and may also include a high level of fillers to provide increased damage resistance without compromising the above benefits.

Abstract: A method comprising the step of melt processing stabilized composition comprising a copolymer comprising from 70 to 95, and preferably 75 to 90 percent by weight of vinyl chloride and from 5 to 30 and preferably 10 to 25 percent by weight of chlorotrifuloroethylene and an effective amount of a stabilizer. The step of melt processing includes extruder processing or roll mill processing. A preferred melt processing step is melt coating the copolymer onto a substrate such as a wire. The present invention includes a substrate such as a wire melt coated with the above-described stabilized copolymer.

Abstract: About equimolar ethylene/chlorotrifluoroethylene copolymer compositions are stabilized against thermal degradation by incorporating therein a stabilizing system comprising (a) a phosphite of an organic plyhydric phenol; (b) a salt of a carboxylic acid and a metal of Group II of the Periodic Table; and (c) an ester of a (4-hydroxy-5-alkylphenyl)alkanoic acid.

Abstract: A melt processable fluoropolymer compositon stabilized against thermal degradation by incorporating therein a stabilizing system comprising (a) a hindered phenol pentaeythritol diphosphite, and (b) a salt of a carboxylic acid and a metal of Group II of the Periodic Table.

Abstract: A foam composition comprising an ethylene-chlorotrifluoroethylene copolymer, a blowing agent and a nucleating agent. The nucleating agent is the carbonate or oxide of a metal cation from the group of metals consisting of magnesium, calcium, barium, zinc and lead. The invention also is a method of making the above foam copolymer composition.

Abstract: A foam composition comprising an ethylene-chlorotrifluoroethylene copolymer, a blowing agent and a nucleating agent. The nucleating agent is the carbonate or oxide of a metal cation from the group of metals consisting of magnesium, calcium, barium, zinc and lead. The invention also is a method of making the above foam copolymer composition.

Abstract: Bisphenol-A/terephthalate/carbonate copolymer substrate in direct adhesive contact with a coating layer of polymerized allyl diglycol carbonate, ("ADGC") without substantial penetration of the copolymeric substrate by the coating layer. The coated article is prepared by forming a layer of monomeric ADGC on the substrate, then polymerizing the ADGC by free-radical initiation at temperatures maintained below successively higher limits as the polymerization progresses, whereby to avoid substantial penetration of the substrate by ADGC or its polymers. The resulting article, such as a clear sheet or plate, is abrasion resistant.

Abstract: A composition is described, useful as a thermoformable polymer, for producing shaped articles having high yield and impact strengths, good heat resistance, and good solvent resistance. The composition, which is cured, contains a crosslinked polycyanurate network polymer in which a high molecular weight thermoplastic polymer, such as a polyestercarbonate, is finely dispersed. The composition possesses a Vicat softening temperature (ASTM 1525) of at least about 10.degree. C. above that of said thermoplastic polymer alone, and an elongation-at-break value (ASTM D-638, at room temperature) at least twice that of said crosslinked polymer alone. Due to the high yield strength, lighter structural articles and components can be fabricated from the composition possessing high structural strength.