Patents by Inventor Daniel C. H. Lin

Daniel C. H. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNAI CONSTRUCTS FOR INHIBITING HSD17B13 EXPRESSION AND METHODS OF USE THEREOF
    Publication number: 20230279399
    Abstract: The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 7, 2023
    Applicant: Amgen Inc.
    Inventors: Daniel C. H. LIN, Michael OLLMANN, Justin K. MURRAY, Bradley J. HERBERICH, Amrita DAS, Patrick COLLINS, Oliver HOMANN
  • RNAI CONSTRUCTS FOR INHIBITING SCAP EXPRESSION AND METHODS OF USE THEREOF
    Publication number: 20220307022
    Abstract: The present invention relates to RNAi constructs for reducing expression of the SCAP gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 29, 2022
    Applicant: AMGEN INC.
    Inventors: Amrita DAS, Bradley J. HERBERICH, Justin K. MURRAY, Oliver HOMANN, Michael OLLMANN, Daniel C.H. LIN
  • Benzimidazole derivatives and their uses
    Patent number: 11332459
    Abstract: The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 17, 2022
    Assignee: TEIJIN PHARMA LIMITED
    Inventors: Michael D. Bartberger, Nagasree Chakka, Hua Gao, Angel Guzman-Perez, Daniel B. Horne, Zihao Hua, Madeleine Kieffer, Daniel C. H. Lin, Benjamin Charles Milgram, Jane Panteleev, Laurie Schenkel, John Stellwagen, Matthew Weiss, Ryan D. White, Wei Zhao
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USES
    Publication number: 20200308145
    Abstract: The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
    Type: Application
    Filed: October 18, 2018
    Publication date: October 1, 2020
    Applicant: Amgen Inc.
    Inventors: Michael D. BARTBERGER, Nagasree CHAKKA, Hua GAO, Angel GUZMAN-PEREZ, Daniel B. HORNE, Zihao HUA, Madeleine KIEFFER, Daniel C. H. Lin, Benjamin Charles MILGRAM, Jane PANTELEEV, Laurie SCHENKEL, John STELLWAGEN, Matthew WEISS, Ryan D. WHITE, Wei ZHAO
  • Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
    Patent number: 9474792
    Abstract: Methods of treating or ameliorating metabolic diseases using a PLA2G12A polypeptide or PLA2G12A mutant polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes mellitus, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 25, 2016
    Assignee: Amgen Inc.
    Inventors: Daniel C. H. Lin, Jinghong Wang, Yang Li
  • Method of Treating Metabolic Disorders Using PLA2G12A Polypeptides and PLA2G12A Mutant Polypeptides
    Publication number: 20160008439
    Abstract: Methods of treating or ameliorating metabolic diseases using a PLA2G12A polypeptide or PLA2G12A mutant polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes mellitus, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 14, 2016
    Inventors: Daniel C.H. LIN, Jinghong WANG, Yang LI
  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Patent number: 7816367
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: October 19, 2010
    Assignee: Amgen Inc.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel C. H. Lin, Jiwen Liu, Jian Luo, Julio C. Medina, Wei Qiu, Jeffrey D. Reagan, Rajiv Sharma, Stephen J. Shuttleworth, Ying Sun, Jian Zhang, Liusheng Zhu, Jinqian Liu, Zhihua Ma, Yingcai Wang, Michael J. Schmitt
  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Patent number: 7649110
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: January 19, 2010
    Assignee: Amgen Inc.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel C. H. Lin, Jinqian Liu, Jiwen Liu, Jian Luo, Zhihua Ma, Julio C. Medina, Wei Qiu, Jeffrey D. Reagan, Rajiv Sharma, Michael J. Schmitt, Stephen J. Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu