Abstract: The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including an isolated polypeptide comprising an enzymatically active domain (EAD) of a Bacillus bacteriophage endolysin.

Abstract: A method of treating or preventing P. acnes and/or S. aureus infection is described, involving contacting P. acnes and/or S. aureus, or a physiological locus infected or susceptible to infection by P. acnes and/or S. aureus, with at least one of specified bacteriolytic agents. Corresponding pharmaceutical compositions containing such bacteriolytic agents are described, which are useful for treatment or prophylaxis of acne vulgaris and/or S. aureus infection, including methicillin-resistant S. aureus infection.

Abstract: The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including an isolated polypeptide comprising an enzymatically active domain (EAD) of a Bacillus bacteriophage endolysin.

Abstract: The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.

Abstract: The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.

Abstract: The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.

Abstract: An isolated oral bacterial polypeptide having amidolytic activity for cleavage of denatured polypeptides and nondenatured serpin polypeptides and particularly a human &agr;1-proteinase inhibitor polypeptide is provided. The mature polypeptide of the invention has a molecular weight of about 70 kD to about 80 kD. Also provided is an isolated nucleic acid sequence encoding the oral bacterial polypeptide of the invention, methods for identifying inhibitors of the polypeptide and compositions such as immunogenic compositions and inhibitor compositions.

Abstract: The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.

Abstract: The present invention identifies a new approach for antibiotic development. By identifying molecules in the cell wall of bacteria responsible for binding bacteriophage lytic enzymes, the present invention focuses on the pathways for possible antibiotic development. The pathway for the bacterial molecule is critical for bacterial survival and thus serves as a target for antibiotic identification.

Abstract: A decorative laminate is provided which includes one or more cellulosic core sheets, one or more decor sheets and optional overlay sheets. In one embodiment, one or more of the overlay sheets and/or decor sheets are impregnated prior to lamination with a mixture of a transparent resin and a photoluminescent material. As a result, the entire upper surface of the laminate visibly luminesces in the presence of exciting radiation. In another embodiment, an image or pattern is printed on one or more of the decor sheets with a ink including an organic photoluminescent material to provide an visibly luminescent image or pattern therein. It is envisioned that the invention could be used to provide a unique and appealing appearance when used as the surfacing for a wide variety of applications, including bowling lanes, game tables, counter-tops, dance floors, and signs such as “exit” signs.

Abstract: A decorative laminate is provided which includes one or more cellulosic core sheets, one or more decor sheets and optional overlay sheets. In one embodiment, one or more of the overlay sheets and/or decor sheets are impregnated prior to lamination with a mixture of a transparent resin and a photoluminescent material. As a result, the entire upper surface of the laminate visibly luminesces in the presence of exciting radiation. In another embodiment, an image or pattern is printed on one or more of the decor sheets with a ink including an organic photoluminescent material to provide an visibly luminescent image or pattern therein. It is envisioned that the invention could be used to provide a unique and appealing appearance when used as the surfacing for a wide variety of applications, including bowling lanes, game tables, counter-tops, dance floors, and signs such as “exit” signs.

Abstract: A decorative laminate is provided which is comprised of a one or more cellulosic core sheets, one or more decor sheets and optional overlay sheets. In one embodiment, one or more of the overlay sheets and/or decor sheets are impregnated prior to lamination with a mixture of a transparent resin and a photoluminescent material. As a result, the entire upper surface of the laminate visibly luminesces in the presence of exciting radiation. In another embodiment, an image or pattern is printed on one or more of the decor sheets with a ink including an organic photoluminescent material to provide an visibly luminescent image or pattern therein. It is envisioned that the invention could be used to provide a unique and appealing appearance when used as the surfacing for a wide variety of applications, including bowling lanes, game tables, counter-tops, dance floors, and signs such as “exit” signs.

Abstract: The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.

Abstract: Layered carbon-carbon composites having improved interlaminar tensile strength are disclosed together with a process for making such composites. A metal catalyst is first deposited on a panel comprising a plurality of layers of carbon fiber cloth. The panel is then exposed to a gaseous hydrocarbon in an inert atmosphere at elevated temperature in order to promote the growth of graphite whiskers between the carbon cloth layers.

Abstract: Layered carbon-carbon composites having improved interlaminar tensile strength are disclosed together with a process for making such composites. A metal catalyst is first deposited on a panel comprising a plurality of layers of carbon fiber cloth. The panel is then exposed to a gaseous hydrocarbon in an inert atmosphere at elevated temperature in order to promote the growth of graphite whiskers between the carbon cloth layers.

Abstract: A carbonizable body is formed by infusing a plurality of preoxidized (preferably stabilized by known processing to have about 9 to 14 weight percent oxygen) polyacrylonitrile fibers in a polar liquid plasticizer, preferably water, capable of extracting a tarry leachate from the fibers. The infusion of the fibers in the plasticizer is continued for a sufficient time for a substantial amount of leachate to form on the surface of the fibers, and are then consolidated or diffusion-bonded to one another or other fibers, as by orienting the treated fibers in a mold and subjecting them to isostatic pressing at relatively low temperatures and pressure. Further processing of the consolidated fibers with appropriate heat treatment in an inert atmosphere will produce a carbonized bulk product with higher values of Young's modulus for the carbonized material than have been previously achieved at such carbonization temperatures.

Abstract: A carbonizable body is formed by infusing a plurality of preoxidized, preferably stabilized by known processing to have about 17 to 30 weight percent oxygen, fibers prepared from pitch, in a non-polar liquid plasticizer, typically quinoline, capable of extracting a tarry leachate from the fibers. The infusion of the fibers in the plasticizer is continued for a sufficient time for a substantial amount of leachate to form on the surface of the fibers. The treated fibers are then consolidated or diffusion-bonded to one another or other fibers, as by orienting the treated fibers in a mold and subjecting them to isostatic pressing at relatively low temperatures and pressure. Further processing of the consolidated fibers with appropriate heat treatment in an inert atmosphere will produce a carbonized bulk product with higher values of Young's modulus for the carbonized material than have been previously achieved at such carbonization temperatures.

Abstract: A carbonizable body is formed by infusing a plurality of preoxidized, preferably stabilized by known processing to have about 9 to 14 weight percent oxygen, polyacrylonitrile fibers in a polar liquid plasticizer, preferably water, capable of extracting a tarry leachate from the fibers. The infusion of the fibers in the plasticizer is continued for a sufficient time for a substantial amount of leachate to form on the surface of the fibers, and are then consolidated or diffusion-bonded to one another or other fibers, as by orienting the treated fibers in a mold and subjecting them to isostatic pressing at relatively low temperatures and pressure. Further processing of the consolidated fibers with appropriate heat treatment in an inert atmosphere will produce a carbonized bulk product with higher values of Young's modulus for the carbonized material than have been previously achieved at such carbonization temperatures.

Abstract: A novel process is provided for the formation of improved carbonized fibrous materials with increased modulus of elasticity and strength as well as decreased diameter. Preferably, the precursor material is acrylonitrile, typically copolymerized with a minor amount of an acrylic monomer such as methyl acrylate. Drawing of the polymer fiber during oxidation is effected at an elevated temperature in the presence of a carboxylic acid (other than formic acid), or its anhydride, within the fiber. It is believed that the acid and/or its anhydride which is formed at the oxidizing temperature serves as a plasticizer and reduces the fiber yield stress and increases fiber plasticity so that the fibers may be drawn by as much as 300% or more in the presence of the acid and/or its anhydride during oxidation, thereby providing the desired improvement in increased modulus of elasticity and tensile strength of carbon fibers formed subsequently by carbonization of the oxidized fibers.