Patents by Inventor Daniel C. Tessier

Daniel C. Tessier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for folding unfolded proteins
    Patent number: 6476194
    Abstract: The present invention relates to methods of treating and diagnosing protein trafficking disorders and controlling secretory protein production. The present invention also relates to methods for folding unfolded proteins, especially in heterelogous expression systems. The methods comprise exposing an unfolded protein to a biological preparation comprising ERp57 in combination with calnexin or calreticulin under conditions to permit folding of the unfolded protein.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: November 5, 2002
    Assignee: National Research Council of Canada
    Inventors: Daniel C. Tessier, Andrë Zapun, John J. M. Bergeron, David Y. Thomas
  • Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT
    Patent number: 6399321
    Abstract: The present invention relates to a method for determining the effect of a test sample on UGGT activity. The method comprises the steps of: a) exposing an acceptor substrate of UGGT such as acid phosphatase to a labeled donor such as UDP-3H-glucose in the presence of the test sample and UGGT; and b) detecting the amount of donor which was transferred to the acceptor substrate wherein a decrease of donor intake when compared to a control means that the test sample is a UGGT stimulator and a decrease means that the test sample is a UGGT inhibitor. The present invention also relates to an isolated mammalian cDNA which encodes for rat UGGT and to methods of producing mammalian UGGT using recombinant vectors.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: June 4, 2002
    Assignee: National Research Council of Canada
    Inventors: Daniel C. Tessier, Daniel Dignard, John J. M. Bergeron, David Y. Thomas