Abstract: An upper for an article of footwear may include one or more of the following: a knitted component forming a collar of the upper, the collar at least partially forming an opening for providing access to an interior of the article of footwear; and a first knit edge and a second knit edge that extend along the collar of the upper, wherein a knitted central portion of the collar extends between the first knit edge and the second knit edge. The collar may consist of a single seam to join together the first knit edge and the second knit edge. The single seam may be offset from a centerline at the rear-most portion of a heel area such that the knitted central portion of the collar extends through the centerline of the heel area.

Abstract: The present invention provides receptor chaperons and means for producing cells having increased and/or decreased expression of nAChR subunit combinations and/or nAChR subtypes, which provide useful models for investigating pharmacological properties of the receptors and regulation of the binding sites of potential nAChR subtypes.

Abstract: A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof.