Patents by Inventor Daniel Caballero-Rivera

Daniel Caballero-Rivera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A4B2 nicotinic acetylcholine receptors with reduced or increased nicotine sensitivity and transgenic mouse model for the same
    Patent number: 10676518
    Abstract: The ?4?2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction. The invention studied the effect of subunit phosphorylation on ?4?2 nAChR function and expression, and eleven residues located in the M3-M4 cytoplasmic loop were mutated to alanine and aspartic acid. When nicotine was used as an agonist, four mutations exhibited a statistically significant hypersensitivity to nicotine (S438D, S469A, Y576A, and S589A). Additionally, two mutations (S516D and T536A) that displayed normal activation with ACh displayed remarkable reductions in sensitivity to nicotine. The invention provides a knock-in mutant construct for the development of a transgenic mouse line with reduced nicotine sensitivity to be used in future studies.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: June 9, 2020
    Assignee: University of Puerto Rico
    Inventors: Jose A Lasalde-Dominicci, Nilza M Biaggi-Labiosa, Emir Aviles-Pagan, Daniel Caballero-Rivera