Abstract: A tissue treating device includes a capsule and first and second clip arms each having a proximal end received within the capsule for movement between an open configuration and a closed configuration. A tissue retention feature extends radially inward from each arm to grip tissue in the tissue clipping configuration and release the tissue in the open configuration. The retention features are coupled to the arms via curved portions. The second clip arm includes a second tissue retention feature extending radially inward from the first portion of the second clip arm toward the longitudinal axis.

Abstract: The present disclosure relates generally to positioning elongate members at a target site within a body lumen, such as for acquiring a biopsy from a peripheral airway. Some embodiments are particularly directed to an elongate member with an embedded transducer positioned at a predefined rotational angle with respect to a projected position of an instrument extended out of a distal opening of a first lumen in the elongate member. In many such embodiments, a rotational transducer may be positioned within a second lumen in the elongate member to generate a radial image including indicia of the embedded transducer. Accordingly, an operator may determine a projected position of the instrument prior to extending the instrument out of the lumen. In several embodiments, the embedded transducer may include a forward imaging transducer, such as a fiber optic.

Abstract: A device includes a housing having a first opening for receiving tissue therein and a distal head disposed at least partly within the housing. The distal head is configured to rotate about a longitudinal axis of the distal head. The device also includes a first holding member coupled to the housing and a second holding member coupled to the distal head. The first and second holding members are configured so that rotating the distal head stretches a first ligation band coupled to the first and second holding members, permitting tissue drawn into the first opening to pass through an opening of the first ligation band.

Abstract: A tissue treating device includes a capsule and first and second clip arms each having a proximal end received within the capsule for movement between an open configuration and a closed configuration. A tissue retention feature extends radially inward from each arm to grip tissue in the tissue clipping configuration and release the tissue in the open configuration. The retention features are coupled to the arms via curved portions. The second clip arm includes a second tissue retention feature extending radially inward from the first portion of the second clip arm toward the longitudinal axis.

Abstract: A device for treating tissue including a capsule including a channel extending therethrough; clip arms extending from a proximal end to a distal end, proximal ends received within the channel to be moved between a tissue receiving configuration, in which distal ends of the arms are separated, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another, the arms including proximal and distal portions, the proximal portion including longitudinal legs extending from the proximal end to the distal portion, a plane of the legs being rotated about a longitudinal axis of the arms from a plane including the distal portion; and a yoke including proximal and distal portions, the distal portion being releasably coupled to the clip legs via a pin, the pin is inserted through the distal portion.

Abstract: A device includes a housing having a first opening for receiving tissue therein and a distal head disposed at least partly within the housing. The distal head is configured to rotate about a longitudinal axis of the distal head. The device also includes a first holding member coupled to the housing and a second holding member coupled to the distal head. The first and second holding members are configured so that rotating the distal head stretches a first ligation band coupled to the first and second holding members, permitting tissue drawn into the first opening to pass through an opening of the first ligation band.

Abstract: A device for treating tissue including a capsule including a channel extending therethrough; clip arms extending from a proximal end to a distal end, proximal ends received within the channel to be moved between a tissue receiving configuration, in which distal ends of the arms are separated, and a tissue clipping configuration, in which distal ends of the arms are moved toward one another, the arms including proximal and distal portions, the proximal portion including longitudinal legs extending from the proximal end to the distal portion, a plane of the legs being rotated about a longitudinal axis of the arms from a plane including the distal portion; and a yoke including proximal and distal portions, the distal portion being releasably coupled to the clip legs via a pin, the pin is inserted through the distal portion.

Abstract: A region-specific monofunctionalization of a phenolic hydroxy onto a polyphenol for the preparation of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, --CN, formyl, carboxy, alkoxy carbonyl of up to 9 carbon atoms, aralkoxy carbonyl or up to 12 carbon atoms and halogen and R' is a hydroxy protective group comprising reacting a polyphenol of the formula ##STR2## wherein R has the above definition with a base to form the corresponding dianion, reacting the latter with a trialkyl borate of the formulaB(OAlk).sub.3wherein Alk is alkyl of 1 to 6 carbon atoms to form a compound of the formula ##STR3## reacting the latter with a reagent capable of introducing a hydroxy protective group and reacting the latter with a hydrolysis agent for the oxygen-boron bond to obtain the corresponding compound of Formula I.