Abstract: The present disclosure provides a cargo delivery fusion polypeptide comprising an endosomolytic polypeptide and a cell penetrating polypeptide; and compositions comprising the cargo delivery fusion polypeptide. The present disclosure also provides methods of delivering a cargo into a target eukaryotic cell, using a composition comprising an amphiphilic polypeptide.

Abstract: An oxygen gas supply device includes a tubular hydrated ion-exchange membrane defining an inner surface, an outer surface and an outlet. An outer catalytic membrane at the outer surface and an inner catalytic membrane at the inner surface are in electrical communication with a direct current power source. Application of electromotive force between the outer and inner catalytic membranes causes an oxygen gas component of the ambient air in contact with one or the other of the outer and inner catalytic membranes to be separated and collected at the other catalytic membrane and thereby be collected as an oxygen gas supply.

Abstract: Inflammation caused by disease states such as rheumatism, gout, neurodegeneration and tumours result in the increased effectiveness of the opioid peptide biphalin or its analogues, due likely to the increased permeability of the “blood-brain barrier”, due to which it becomes possible to use the opioid peptide to produce a new analgesic for use during inflammation caused by rheumatism, gout, neurodegeneration, post-surgical or post-accidental trauma or tumours.

Abstract: Provided are compounds represented by: wherein R1 is a D-alanine, D-serine, D-threonine, D-methionine, D-leucine, D-asparagine or D-glutamine side chain and R2 is a phenylalanine or tryptophan side-chain, and compositions containing such compounds.

Abstract: Inflammation caused by disease states such as rheumatism, gout, neurodegeneration and tumours result in the increased effectiveness of the opioid peptide biphalin or its analogues, due likely to the increased permeability of the “blood-brain barrier”, due to which it becomes possible to use the opioid peptide to produce a new analgesic for use during inflammation caused by rheumatism, gout, neurodegeneration, post-surgical or post-accidental trauma or tumours.

Abstract: A control system for a marine vessel having one or more engines and a transmission associated with each engine is disclosed. The control system includes one or more control stations, each having a control arm and arm position means coupled to the control arm for providing an electrical signal that represents a position of the control arm within its operating range. The system includes one or more electronic control units, each of which is electro-mechanically coupled to an engine and a transmission. A first electronic control unit (ECU) includes input means for receiving the electrical signal, control means for controlling a throttle of a first engine and shift position of a first transmission based on the electrical signal, and output means for providing a control signal that represents a current position of the control arm to a second ECU.

Abstract: A modular component securing apparatus includes a chassis, a securing member moveably coupled to the chassis and including an activation surface, a biasing member coupled to the securing member and operable to bias the securing member into a deactivated position, a component detection member coupled to the securing member and operable to move the securing member relative to the chassis and into an activated position in response to the component detection member being engaged by a modular component, and an activation member including an activator surface. In response to the securing member being moved into the activated position, the activator surface may engage the activation surface in order to move the securing member relative to the chassis and into a securing position. The securing member may be moved into the securing position only when a modular component is positioned in the chassis.

Abstract: Application of peptides with analgesic properties as the active ingredient in devices for the direct application of medication to the site of their expected analgesic activity, particularly in the central nervous system.

Abstract: A modular component securing apparatus includes a chassis, a securing member moveably coupled to the chassis and including an activation surface, a biasing member coupled to the securing member and operable to bias the securing member into a deactivated position, a component detection member coupled to the securing member and operable to move the securing member relative to the chassis and into an activated position in response to the component detection member being engaged by a modular component, and an activation member including an activator surface. In response to the securing member being moved into the activated position, the activator surface may engage the activation surface in order to move the securing member relative to the chassis and into a securing position. The securing member may be moved into the securing position only when a modular component is positioned in the chassis.

Abstract: According to some embodiments, a ventilated toilet has an airflow path through an overflow tube to an air space above a water level in a tank, and an air vent path leading from the air space. In some embodiments, the air vent path includes an air duct or conduit leading to an exhaust fan. In some embodiments, the device further includes a dip tube for providing ventilation to the air space upon lowering of the water level in the tank.

Abstract: The present invention provides a novel chimeric peptide containing an opioid peptide moiety and a nociceptive peptide moiety for producing analgesia

Abstract: A control system for a marine vessel having one or more engines and a transmission associated with each engine is disclosed. The control system includes one or more control stations, each having a control arm and arm position means coupled to the control arm for providing an electrical signal that represents a position of the control arm within its operating range. The system includes one or more electronic control units, each of which is electro-mechanically coupled to an engine and a transmission. A first electronic control unit (ECU) includes input means for receiving the electrical signal, control means for controlling a throttle of a first engine and shift position of a first transmission based on the electrical signal, and output means for providing a control signal that represents a current position of the control arm to a second ECU.

Abstract: The invention features an antimicrobial composition comprising a substance P peptide and methods of inhibiting growth of a microorganism by contacting the microorganism with a substance P peptide. Bacterial and fungal pathogens are inhibited by the substance P compositions.

Abstract: An information handling system lid releases from an associated housing with an actuator that frees the lid and then pushes the lid from a secured position to an unsecured position for ease of removal. The actuator rotationally couples through the housing to translate a user rotation of the actuator to open and then move the lid. On the interior of the housing, the actuator is a cam having a latch push and an inclined surface. The latch push moves a latch to an open position upon initial movement of the actuator and holds the latch in the open position to release a latch catch of the lid and allow movement of the lid. The inclined surface pushes against a lid removal protrusion extending from the lid and moves the lid an increasing distance as the actuator turns to complete release of the lid from the housing by sliding hooks of the lid from slots of the housing.

Abstract: A blank expansion card adjusts to selected widths within an information handling system expansion card bay having horizontally aligned connectors in order to provide support to an adjacent expansion card. The blank expansion card has a base that couples with an expansion card connector, a body extending from the base along a side wall of the expansion card bay, and an adjustable member that extends from the body an adjustable distance to engage the adjacent expansion card and ensure that the expansion card remains in position against an opposing side wall of the expansion card bay. The adjustable member essentially adjusts the width of the expansion card bay to snuggly fit expansion cards of varying width by extending from or retracting into a housing of the expansion card blank body.

Abstract: A processor retainer assembly prevents inadvertent removal of a processor from a circuit board socket by forces exerted on an information handling system that are translated from a heat sink to the processor by the coupling of thermal grease between the heat sink and the processor. A retention frame couples to a motherboard around the processor socket to support movement of the processor retainer between open and closed positions. A securing device hinge rotationally couples the processor retainer to the retention frame and a securing device latch locks the processor retainer in the closed position to restrict movement of the processor from the socket. A heat sink contacts the processor through an opening in the processor retainer. Heat sink supports extending from the retention frame engage the heat sink so that a single processor retainer assembly retains the processor in the socket and the heat sink proximate to the processor.

Abstract: A high speed aluminum wire anodizing machine and process are provided which includes anodizing aluminum wire in an anodizer tank having wire ingress and egress openings. At least two adjacent rotatable wire accumulator drums are provided in the tank, preferably with means for producing a flow of anodizing electrolytes into each of the drums through an end hub thereof and out of the sidewalls of the drums passed circumferential wire separators. An anode is located proximal to the wire ingress opening, preferably in a contact cell which has an adjustable wire egress window. At least one cathode is provided in the tank. The cathode is preferably either between the drums or a pair of cathodes are provided above and below the drums adjacent to the sidwalls thereof, or both.