Abstract: A centrifugal pump with a hydrodynamic bearing and a double involute is disclosed. Some embodiments may include an impeller housing comprising a fluid entrance to allow fluid to enter and an impeller located within the impeller housing, the impeller comprising a plurality of impeller blades, a plurality of fluid channels between the impeller blades, and a motor magnet. The impeller may rotate within the impeller housing about a pump centerline in response to an electromagnetic field and the fluid channels may each allow fluid to pass through when the impeller rotates. Embodiments may also include one or more hydrodynamic bearings positioned between the impeller and the impeller housing to support generated loads and a double involute coupled with the impeller housing and positioned to receive fluid exiting the plurality of fluid channels. Further embodiments may include a motor stator to generate the electromagnetic field. Other embodiments are disclosed and claimed.

Abstract: Generally speaking, a system with a metallic component and a thermoplastic component is disclosed. The metallic component may include a metallic outer surface and the thermoplastic component may be formed around the metallic outer surface to create a seal between the thermoplastic housing and the metallic component. In some embodiments, the thermoplastic component may include an inner surface and an outer surface where the inner surface is formed adjacent to an in contact with the metallic outer surface. Embodiments may also include a sealing ring positioned on the outer surface of the thermoplastic housing to provide a compressive spring force to the thermoplastic housing, where the force applied to the thermoplastic housing improves the seal between the thermoplastic component and the metallic component. In a further embodiment, the metallic component is a metallic cold plate and the thermoplastic component is a thermoplastic pump housing. Other embodiments are disclosed and claimed.

Abstract: An exit roll for use in an image forming device. The exit roll may include a body and a kicker section each configured to mount to a shaft. The kicker section may include a plurality of fingers spaced around the periphery. Each of the fingers may include a first section that is substantially parallel to the shaft, and a second section that extends outward way from the shaft. The fingers may be flexible in an upwards and downwards direction into and away from the shaft. The exit roll is constructed to move media sheets out of the exit port and away from the image forming device.

Abstract: Methods and devices for moving media sheets through an image forming device. A sensor is positioned within an input area to determine a height of a media stack. When the media stack is full, a top-most sheet of the media stack is physically closer to the beginning point of the media path. When the media stack is depleted, the top-most sheet is positioned a further distance away from the beginning point. Movement of the media sheet is determined based on the height of the media stack. When the media stack is above a predetermined amount, the media sheet is moved according to a first algorithm. When the media stack is below the predetermined amount, the media sheet is moved according to a second algorithm.

Abstract: A method is provided for evaluating drug compounds based on their binding properties to human serum albumin wherein structural information at particular albumin binding regions is entered into a computer database and assessed with regard to particular contacting binding residues located in accordance with the invention. The information obtained through the computer database is thus useful in assessing and predicting drug interactions at albumin binding sites. Further, protein fragments including one or more albumin binding sites are provided which can be used in methods of assessing and designing drugs.

Abstract: An isolated fusion protein is provided which is a conjugate of a therapeutic polypeptide and an albumin fragment, such as a fragment including an individual domain or subdomain of albumin, or a polymer of albumin (e.g., dimers, trimers, etc.) and which is used to optimize the half-life of that therapeutic agent in the bloodstream in a tunable fashion based on the molecular weight of the fragment or polymer. Albumin fragments useful in the invention include fragments containing any of the individual domains and subdomains of human serum albumin, as well as fragments including specific combinations of binding regions or subdomains. The present invention thus provides fragments or polymers which will allow for optimizing half-lives of therapeutic polypeptides depending on their molecular weight, and this will optimizes protein and vaccine therapeutics to have desired half lives for their greatest effectiveness.

Abstract: An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance of the conductive film or gel caused by the presence of infrared radiation and the effect of the infrared radiation on the thermal-sensing protein, and means to analyze the changes in conductivity or resistance in the conductive film caused by the infrared radiation so as to determine if infrared radiation is present.

Abstract: An image forming device in a color printer or the like includes duplex printing. Multiple media sheets are moved through a media path which includes a primary path and a duplex path. Various parameters of the image forming device control the interpage gap between sheets. Parameters include peek-a-boo duplexing, sharing of motors within the drive rollers, and sharing of power supplies.

Abstract: According to some embodiments, systems for an integrated cold plate and heat exchanger may be provided. In some embodiments, a device may comprise a cold plate to transfer heat to a fluid and a heat spreader integral with the cold plate, the heat spreader to accept heat from an electronic device. In some embodiments, the heat spreader and the cold plate are monolithic.

Abstract: According to some embodiments, a first sealing portion is provided on a valve shaft to seal a chamber. The first sealing portion may, for example, seal the chamber when the valve shaft is inserted a first distance into an opening of the chamber. A second sealing portion may also be provided on the valve shaft to seal the chamber when the valve shaft is inserted a second distance into the opening.

Abstract: According to some embodiments, systems for low cost coaxial liquid cooling may be provided. In some embodiments, a system may comprise an axis. The system may further comprise a heat exchanger coupled to a pump, wherein the heat exchanger and the pump are oriented with respect to the axis.

Abstract: According to some embodiments, systems for an integrated pump and reservoir may be provided. In some embodiments, a pump may comprise a housing defining an inlet to accept a fluid and an outlet to evacuate the fluid, an impeller disposed within the housing, wherein the impeller is to move the fluid toward the outlet, a motor to power the impeller, a reservoir hydraulically coupled to the inlet, and a cold plate disposed at least partially within the housing.

Abstract: An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the resulting fusion protein, and the protein may be of the endocapsid form when fused at the C terminus or an exocapsid form when fused at the N terminus. These fusion proteins may self-assemble into a variety of useful higher polymeric forms, e.g., capsid or other polymeric aggregate, and they are advantageous in that they are useful in a variety of applications, including human and veterinary vaccines and therapeutics, blood substitutes, image contrast agents, metal chelating agents, gelling agents, protein purification platforms, and therapeutic receptor-binding proteins.

Abstract: A method is provided for increasing the safety and efficacy of albumin-binding drugs such as those used as anti-cancer, anti-infective, or anti-hypertensive drugs, or for numerous other conditions. In the preferred method, the invention modulates those drugs which bind at the IB site on human serum albumin by co-administering a compound which is highly tolerable to humans and which can bind competitively with those albumin-binding drugs at the IB binding site so as to increase the safety and efficacy of the drug. The invention is advantageous in that by administering the highly tolerable compound in a sufficient amount to compete with the targeted drug, the latter can be administered at a much lower dosage while maintaining or exceeding its potency. Compositions containing the combination of highly tolerable compound and albumin-bind drugs are also disclosed.

Abstract: An image forming device having a body that receives a removable media input tray. The media input tray comprises a manual feed section and an input tray section each for feeding a media sheet to an aligner nip. The manual feed section includes a channel through which a user slides a media sheet into a main media path. The input tray section includes a space for holding a stack of media sheets that are individually picked and moved into the main media path.

Abstract: Alignment nip regulation may be implemented by controlling the approach of media to an alignment nip. Where media is fed from a plurality of sources and from a plurality of approach angles through a common alignment nip, nip entry may be controlled by focusing the media through a diverter or a jog in an existing path to alter the course followed by the media sheets. The diverter may be configured to direct the media sheets to a contact point at or near the alignment nip, such as on a roller that forms the alignment nip. Alternatively, media sheets arriving at the nip from separate conduits may be separately directed to a common contact point near the alignment nip. In either case, one or more sensors may detect the approach of the media sheets at a time when the sheets are a common, predetermined distance away from the alignment nip.

Abstract: A process extracts liquid from a fabric having a first content of liquid through the use of a mechanical extraction means and penetration of a surfactant monolayer created at the air-liquid interface of the first liquid contained in the fabric by a surfactant penetrant.

Abstract: A method is provided for identifying and isolating peptides capable of binding of inorganic materials such as silica, silver, germanium, cobalt, iron, or oxides thereof, or other materials on a nanometric scale such as carbon nanotubes, using a combinatorial phage display peptide library and a polymerase-chain reaction (PCR) step to obtain specific amino acids sequences. In the method of the invention, a combinatorial phage display library is used to isolate and select the desired binding peptides by a series of steps of target binding of phage with the nanometric material of interest, elution and purification of the bound phages, and amplification using PCR to determine the sequences of phages producing the desired binding peptides. The binding peptides of the invention are particularly advantageous in that they may be used as templates to guide the development of useful structures on a nanometric scale.

Abstract: A plasma measurement device comprises data sensors for sensing properties of the plasma environment together with diagnostic sensors for measuring properties related to the functional integrity of the measurement device. Events reported by the diagnostic sensors of the invention may be interpreted as failures of the measurement device, as warnings requiring operator attention or intervention, or alternatively may be employed as data in a predictive algorithm to estimate the remaining useful lifetime of the device. By providing an ability to detect events indicative of faults or failures in a plasma measurement device during use of the device, the invention provides enhanced certainty and confidence in the integrity of data collected by the plasma measurement device.

Abstract: A method and apparatus for moving media through an image forming device using a roller having a recessed kick area is described herein. The roller includes a contact surface having a first radius that extends 360° around the roller. The roller also includes at least one recess that extends inwardly from the contact surface along a sector of the roller, where a bottom surface of the recess has a second radius less than the first radius. As a result, along the sector of the roller having the recess, the width of the contact surface is less than the width of the roller. The recess comprises at least one kick surface on one end of the recess. As the roller rotates, the kick surface kicks a trailing edge of media exiting the exit roller system into a desired bin of the image forming device.