Abstract: A spirit bottle greeting card is configured to contain a small bottle of spirits as a gift for a recipient. The spirits are typically in 50 ml spirit bottle, a quantity of sufficient size for the sender to “toast” the occasion for the recipient. The spirit bottle greeting card includes a cover that is attached to a container with a hinge. A spirit bottle retainer is received in the container and suspends the spirit bottle within an interior cavity. The spirit bottle retainer has a recess to releasably and captively receive the spirit bottle. The recess has a neck portion to conform to a neck of the spirit bottle, a shoulder portion to conform to a shoulder of the spirit bottle, and a body portion to conform to a body of the spirit bottle. A plurality of retaining tabs hold the spirit bottle in a snap fit configuration.