Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: A system for electrically stimulating a user includes an electrode assembly, a control module, an electrode usage module, a communication module, a stimulus generator, and a client application. Additionally or alternatively, the system 100 can include any or all of: a head apparatus, a power source, a sensor subsystem, an electrical coupling subsystem, a user device, and/or any other suitable component(s). A method for electrically stimulating a user includes reading a tag of the electrode assembly, applying electrical stimulation to a user, determining and/or updating an electrode usage, and triggering an action based on the tag. Additionally or alternatively, the method can include any or all of: coupling an electrode assembly with a head apparatus, receiving an input from a user to initiate an electrical stimulation session, transmitting tag information, updating the tag, applying electrical stimulation to a user, verifying tag information, and/or any other suitable process(es).

Abstract: A system and method for stimulating a user, the system comprising: a set of pads configured at head regions of the user; a band having a first end coupled to a first pad of the set of pads and a second end coupled to a second pad of the set of pads; a bridge coupled the band and to an electrode during use; and a set of links, each link coupled at a first region to an interior portion of its corresponding pad, and coupled at a second region to the bridge, having an elastic modulus above a threshold modulus such that: in a first mode, displacement of the set of pads produces displacement of the electrode away from the head region of the user, and in a second mode, release of the set of pads orients protrusions of the electrode approximately normal to the head region.

Abstract: A system for electrically stimulating a user includes an electrode assembly, a control module, an electrode usage module, a communication module, a stimulus generator, and a client application. Additionally or alternatively, the system 100 can include any or all of: a head apparatus, a power source, a sensor subsystem, an electrical coupling subsystem, a user device, and/or any other suitable component(s). A method for electrically stimulating a user includes reading a tag of the electrode assembly, applying electrical stimulation to a user, determining and/or updating an electrode usage, and triggering an action based on the tag. Additionally or alternatively, the method can include any or all of: coupling an electrode assembly with a head apparatus, receiving an input from a user to initiate an electrical stimulation session, transmitting tag information, updating the tag, applying electrical stimulation to a user, verifying tag information, and/or any other suitable process(es).

Abstract: A system and method for stimulating a user, the system comprising: a set of pads configured at head regions of the user; a band having a first end coupled to a first pad of the set of pads and a second end coupled to a second pad of the set of pads; a bridge coupled the band and to an electrode during use; and a set of links, each link coupled at a first region to an interior portion of its corresponding pad, and coupled at a second region to the bridge, having an elastic modulus above a threshold modulus such that: in a first mode, displacement of the set of pads produces displacement of the electrode away from the head region of the user, and in a second mode, release of the set of pads orients protrusions of the electrode approximately normal to the head region.

Abstract: A system and method for stimulating a user, the system comprising: a set of pads configured at head regions of the user; a band having a first end coupled to a first pad of the set of pads and a second end coupled to a second pad of the set of pads; a bridge coupled the band and to an electrode during use; and a set of links, each link coupled at a first region to an interior portion of its corresponding pad, and coupled at a second region to the bridge, having an elastic modulus above a threshold modulus such that: in a first mode, displacement of the set of pads produces displacement of the electrode away from the head region of the user, and in a second mode, release of the set of pads orients protrusions of the electrode approximately normal to the head region.

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: A system and method for stimulating a user, the system comprising: a set of pads configured at head regions of the user; a band having a first end coupled to a first pad of the set of pads and a second end coupled to a second pad of the set of pads; a bridge coupled the band and to an electrode during use; and a set of links, each link coupled at a first region to an interior portion of its corresponding pad, and coupled at a second region to the bridge, having an elastic modulus above a threshold modulus such that: in a first mode, displacement of the set of pads produces displacement of the electrode away from the head region of the user, and in a second mode, release of the set of pads orients protrusions of the electrode approximately normal to the head region.

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: Disclosed are methods, devices, and systems for inducing neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Further disclosed are methods, devices, and systems for identifying where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces are also disclosed, including diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.

Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Methods described herein may comprise contacting the substrate of a lead body and/or an electrode of a medical electrical lead system with at least one bioactive agent, where the lead body and the electrode are connected to each other.

Abstract: Medical electrical lead systems and related methods are described. The lead systems may be configured to be at least partially implanted in neural tissue of a subject, such as a brain of a subject. Some variations of the lead systems may comprise a lead body, an electrode connected to the lead body, and a bioactive agent. The electrode and/or lead body may comprise a substrate, and the bioactive agent may be supported by the substrate (e.g., by a substantial portion of the area of the substrate). Examples of bioactive agents that may be used in the lead system include bioactive agents that promote neural adhesion and living cells that have been biologically manipulated, engineered cells, and cells of a particular phenotype and/or adapted to induce a desired neural or glial response.