Abstract: The present disclosure is directed to isolated or recombinant antigen binding proteins, such as antibodies, which bind to coronavirus spike (S) protein receptor binding domain (RBD), including S protein RBD from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The present disclosure is also directed to the use of the isolated or recombinant proteins as therapeutic, prophylactic and/or diagnostic agents for respiratory conditions associated with coronavirus infection, such as infection by SARS-CoV-2. The present disclosure is also related to nucleic acid sequences which encode said antigen binding proteins and their expression in recombinant host cells.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The present disclosure relates to methods of generating antibodies with improved specificity and/or affinity for a target antigen, as well as B-cells and hybridomas expressing the antibodies and compositions comprising antibodies with improved specificity and/or affinity for the target antigen.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The present disclosure generally relates to proteins containing immunoglobulin light chain variable region homodimers, to methods of providing such proteins and to various uses of such proteins. In one example, the disclosure provides a method for screening a plurality of immunoglobulin homodimers, each homodimer comprising two identical light chain variable domain monomers, wherein screening of the immunoglobulin homodimers comprises identifying homodimers that are capable of binding specifically to an antigen to form an immunoglobulin-antigen complex.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The present disclosure provides an isolated protein comprising an antibody heavy chain variable region (VH) comprising a negatively charged amino acid at position 28 and/or 31 and/or 32 and/or 33 and/or 35 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The invention relates to a device for detecting the abrasive wear on components of water turbines, having a wearing body, and a measuring unit for detecting the wear on the wearing body. The invention is characterized in that the wearing body is arranged in the flow flowing through the water turbine, the wearing body is implemented as a sonotrode and is connected to an ultrasound generator, and the measuring unit is implemented to measure the resonant frequency of the sonotrode.

Abstract: The present disclosure provides proteins comprising antibody variable regions that bind specifically to NPY and PYY and uses thereof and methods of treating or preventing cancer or inducing an immune response by inhibiting NPY and PYY.

Abstract: The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (VL) which may comprise at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

Abstract: The invention relates to a device for detecting the abrasive wear on components of water turbines, having a wearing body, and a measuring unit for detecting the wear on the wearing body. The invention is characterized in that the wearing body is arranged in the flow flowing through the water turbine, the wearing body is implemented as a sonotrode and is connected to an ultrasound generator, and the measuring unit is implemented to measure the resonant frequency of the sonotrode.

Abstract: The present disclosure provides an isolated protein comprising an antibody heavy chain variable region (VH) comprising a negatively charged amino acid at position 28 and/or 31 and/or 32 and/or 33 and/or 35 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.