Patents by Inventor Daniel Christopher Leslie

Daniel Christopher Leslie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11919971
    Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: March 5, 2024
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher Leslie, Thomas Doyle, Anna Waterhouse, Melissa Rodas, Alexander L. Watters, Michael Super, Donald E. Ingber
  • Publication number: 20190144567
    Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 16, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher LESLIE, Thomas DOYLE, Anna WATERHOUSE, Melissa RODAS, Alexander L. WATTERS, Michael SUPER, Donald E. INGBER
  • Publication number: 20140158233
    Abstract: The present invention is directed to systems and methods for delivering aerosolized micro-droplets into microfluidic devices. In some embodiments, the microfluidic devices are designed for the culture of living cells at an air interface. In some embodiments, the systems and methods described herein can be used to deliver aerosolized micro-droplet into detection systems and small animals, tissues, organs and organisms.
    Type: Application
    Filed: May 9, 2012
    Publication date: June 12, 2014
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher Leslie, Karel Domansky, Geraldine A. Hamilton, Anthony Bahinski, Donald E. Ingber
  • Publication number: 20130157283
    Abstract: A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid.
    Type: Application
    Filed: January 19, 2011
    Publication date: June 20, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Chong Wing Yung, Donald E. Ingber, Ryan Mcomber Cooper, Frank Vollmer, Karel Domansky, Daniel Christopher Leslie, Michael Super