Patents by Inventor Daniel Cimino

Daniel Cimino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists
    Patent number: 7232659
    Abstract: The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection of ligand-GPCR complexes and to methods for identifying compounds as agonists, partial agonists or antagonists of the binding of G-protein coupled receptors to G-protein and for use of these compounds in the treatment of conditions or disease states in a mammalian subject or patient, including humans, where G-protein coupled receptor binding to G-protein is implicated.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: June 19, 2007
    Assignee: STC.UNM
    Inventors: Larry A. Sklar, Eric R. Prossnitz, Peter Simons, Anna Waller, Daniel Cimino, Sean Biggs
  • Bead-based detection of ligand-GPCR-G protein complexes
    Patent number: 7189519
    Abstract: The present invention provides a general approach for G protein coupled receptors that may be used to define agonists and antagonists, and the specificity of receptor coupling to G protein subunits. Methods of the present invention use small volumes (microliters) and are compatible with high throughput flow cytometry. When assays of the present invention are multiplexed, the specificity of the interactions of a receptor with many G proteins may be determined simultaneously.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: March 13, 2007
    Assignees: STC.UNM, Univeristy of Michigan
    Inventors: Larry A. Sklar, Tione Buranda, Daniel Cimino, Alex T. Key, Richard Neubig, Peter C. Simons, Eric R. Prossnitz, Mei Shi
  • Bead-based detection of ligand-GPCR-G protein complexes
    Publication number: 20030235863
    Abstract: The present invention provides a general approach for G protein coupled receptors that may be used to define agonists and antagonists, and the specificity of receptor coupling to G protein subunits. Methods of the present invention use small volumes (microliters) and are compatible with high throughput flow cytometry. When assays of the present invention are multiplexed, the specificity of the interactions of a receptor with many G proteins may be determined simultaneously.
    Type: Application
    Filed: May 5, 2003
    Publication date: December 25, 2003
    Inventors: Larry A. Sklar, Tione Buranda, Daniel Cimino, T. Alex Key, Richard Neubig, Peter C. Simons, Eric R. Prossnitz, Mei Shi