Abstract: A method of obtaining a three-dimensional digital model of an artificial object, made up of a plurality of geometric primitives, the artificial object being in a single two-dimensional photograph, the method comprising: using edge detection to define a two-dimensional outline of the artificial object within the photograph; interactively allowing a user to define two-dimensional profiles of successive ones of the geometric primitives; interactively allowing a user to sweep respective profiles over an extent of a corresponding one of the geometric primitives within the image; generating successive three-dimensional model parts from existing detected edges of the corresponding geometric primitives and the sweeping of the respective profile; and aligning the plurality of three-dimensional model parts to form the three-dimensional model.

Abstract: The invention relates to compositions and methods for improving memory and related functions as alertness, attention, concentration, learning, and language processing. More particularly, the invention relates to compositions comprising at least two drugs selected from cinacalcet, baclofen, acamprosate, mexiletine, sulfisoxazole and torasemide useful to enhance memory and related functions in healthy subjects or subjects suffering from conditions or disorders having a negative impact on their memory.

Abstract: A method of mapping a collection of images, or other higher dimensional items including text documents, and three-and-higher dimensional objects, onto a navigable grid for browsing via a user interface comprises obtaining for each of the images a list of nearest neighbor images and similarity scores for each nearest neighbor; placing a first image on a cell within a grid; from a respective list of nearest neighbors of said first image, finding images that maximize a compatibility score with images already placed on the grid and placing resulting images on neighboring cells; and continuing to place further images on the grid until all cells visible to a user are filled with images. As the user pans or zooms the grid, more cells move into the visible area of the screen and are filled with images in the same way.

Abstract: The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.

Abstract: A method of obtaining a three-dimensional digital model of an artificial object, made up of a plurality of geometric primitives, the artificial object being in a single two-dimensional photograph, the method comprising: using edge detection to define a two-dimensional outline of the artificial object within the photograph; interactively allowing a user to define two-dimensional profiles of successive ones of the geometric primitives; interactively allowing a user to sweep respective profiles over an extent of a corresponding one of the geometric primitives within the image; generating successive three-dimensional model parts from existing detected edges of the corresponding geometric primitives and the sweeping of the respective profile; and aligning the plurality of three-dimensional model parts to form the three-dimensional model.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: The present disclosure provides a three-dimensional point cloud model reconstruction method, a computer readable storage medium and a device.

Abstract: The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.

Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.

Abstract: The present disclosure provides a navigation method based on a three-dimensional scene, comprising: calculating an interest value of a viewpoint of a camera based on heights, volumes, irregularities and uniqueness of buildings in a scene; generating trajectory parameters of the camera according to the interest value of the viewpoint, so as to navigate according to the trajectory parameters. The navigation method based on a three-dimensional scene of the present disclosure obtains a reasonable interest value of the viewpoint based on heights, volumes, irregularities and uniqueness of the buildings, thereby achieving a high-quality navigation.

Abstract: To manage a plurality of parking spaces, one or more images are acquired, with each parking space appearing in at least one image. Periodically acquired images of occupancy and identity are used in directing a customer to a parked vehicle. Periodically acquired images of just occupancy are used in controlling respective environmental aspects, such as illumination and ventilation, of the parking spaces. For these purposes, the images are classified automatically as “vacant” or “occupied”, and are displayed along with their classifications so that the classifications can be corrected manually.

Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ? toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: The present disclosure relates to a computer-implemented method for electronic design verification. Embodiments may include providing an electronic design including, at least in part, one or more hardware description languages and one or more software programming languages. Embodiments may further include calculating configuration information without analyzing the electronic design, wherein the configuration information includes one or more memory elements configured to control a mode of operation of the electronic design. Embodiments may also include determining a change in the one or more memory elements and altering a function associated with the electronic design verification based upon, at least in part, the determined change.

Abstract: A method for reconstructing surface from a point cloud includes following steps: (a) extracting skeletal curves from an input point cloud; (b) editing the extracted skeletal curves, and assigning sweeping path; (c) obtaining sliced point clouds along the edited skeletal curves, and fitting a closed NURBS curve according to the sliced point clouds; (d) reconstructing the point cloud to get generalized cylinders along the assigned sweeping path, according to the closed NURBS curves; (e) merging the generalized cylinders into a single surface, and smoothing intersections of the generalized cylinders so as to reconstruct surface from the point cloud. The invention further relates to a system for reconstructing surface from a point cloud. The invention can reconstruct the surface with high accuracy by the minimum interactions, and can deal with point cloud data having missing region caused by occlusion. In addition, the invention can achieve high reconstruction quality and fine controllability.

Abstract: The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signalling and thyroid hormone pathway in a subject.

Abstract: To manage a plurality of parking spaces, one or more images are acquired, with each parking space appearing in at least one image. Periodically acquired images of occupancy and identity are used in directing a customer to a parked vehicle. Periodically acquired images of just occupancy are used in controlling respective environmental aspects, such as illumination and ventilation, of the parking spaces. For these purposes, the images are classified automatically as “vacant” or “occupied”, and are displayed along with their classifications so that the classifications can be corrected manually.

Abstract: A method for depth mapping includes projecting a pattern of optical radiation onto an object. A first image of the pattern on the object is captured using a first image sensor, and this image is processed to generate pattern-based depth data with respect to the object. A second image of the object is captured using a second image sensor, and the second image is processed together with another image to generate stereoscopic depth data with respect to the object. The pattern-based depth data is combined with the stereoscopic depth data to create a depth map of the object.