Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Some embodiments of the invention may reduce the amount of time a consumer spends coordinating a move. A system is provided which may guide the consumer through the process of planning the move, including developing an inventory of items to be transported. Based on the consumer's plan, quotes for the move may be provided from multiple movers, and each quote may be an exact price that a mover will charge, rather than merely an estimate. To enable movers to provide exact quotes, some embodiments of the invention implement a standard pricing methodology. The system may allow movers to define pricing information in accordance with the methodology, and this information may be used to calculate a quote for a move when a consumer requests one.

Abstract: Some embodiments of the invention may reduce the amount of time a consumer spends coordinating a move. A system is provided which may guide the consumer through the process of planning the move, including developing an inventory of items to be transported. Based on the consumer's plan, quotes for the move may be provided from multiple movers, and each quote may be an exact price that a mover will charge, rather than merely an estimate. To enable movers to provide exact quotes, some embodiments of the invention implement a standard pricing methodology. The system may allow movers to define pricing information in accordance with the methodology, and this information may be used to calculate a quote for a move when a consumer requests one.

Abstract: Some embodiments of the invention may reduce the amount of time a consumer spends coordinating a move. A system is provided which may guide the consumer through the process of planning the move, including developing an inventory of items to be transported. Based on the consumer's plan, quotes for the move may be provided from multiple movers, and each quote may be an exact price that a mover will charge, rather than merely an estimate. To enable movers to provide exact quotes, some embodiments of the invention implement a standard pricing methodology. The system may allow movers to define pricing information in accordance with the methodology, and this information may be used to calculate a quote for a move when a consumer requests one.

Abstract: Some embodiments of the invention may reduce the amount of time a consumer spends coordinating a move. A system is provided which may guide the consumer through the process of planning the move, including developing an inventory of items to be transported. Based on the consumer's plan, quotes for the move may be provided from multiple movers, and each quote may be an exact price that a mover will charge, rather than merely an estimate. To enable movers to provide exact quotes, some embodiments of the invention implement a standard pricing methodology. The system may allow movers to define pricing information in accordance with the methodology, and this information may be used to calculate a quote for a move when a consumer requests one.

Abstract: Neurosurgical devices including or used with cannulas or catheters and associated systems and methods are disclosed herein. The neurosurgical devices can include, for example, a cannula having a main portion and an angle-forming member proximate a distal end of the main portion. The angle-forming member can be configured to transition from a substantially straight configuration while the cannula is advanced through tissue along a substantially straight first portion of a path to an angled configuration when the angle-forming member reaches an end of the substantially straight first portion of the path. The neurosurgical devices also can include, for example, a neurosurgical catheter including a surface disrupter, an elongated macerator, or a lateral opening. Neurosurgical catheterization portals also are disclosed. The neurosurgical catheterization portals can, for example, have an adjustable portal that is movable relative to a body to accommodate different entry angles of a catheterization path.

Abstract: A lead includes a lead body extending from a lead proximal end portion to a lead distal end portion and having an intermediate portion therebetween, one or more tissue sensing/stimulation electrodes disposed along the lead body, one or more terminal connections disposed along the lead proximal end portion. The lead further includes one or more conductors contained within the lead body extending between the tissue sensing/stimulation electrodes and the terminal connections, and a fibrous matrix coating is disposed onto at least a portion of the lead body and/or sensing/stimulation electrodes.

Abstract: A cardiac lead comprising a lead body extending from a proximal end portion to a distal end portion; a cardiac electrode disposed along the lead body; and a coating associated with at least a portion of the electrode, wherein the coating comprises a conductive polymer.

Abstract: A medical lead including a lead body extending from a first end portion to a second end portion and a coating disposed along a portion of the lead, wherein the coating includes at least one matrix polymer layer, at least one anti-inflammatory agent and at least one anti-proliferative agent.

Abstract: A lead assembly is provided that includes an outer insulative body, at least one conductor disposed within the outer insulative body, and an inner electrode coupled with the at least one conductor. The lead assembly further includes an outer electrode disposed over the inner electrode, where the outer electrode coupled with at least a portion of the inner electrode outer surface, for example by laser welding or magnetic swaging.

Abstract: An electro-medical system includes a porous covering that has a pore structure to resist in vivo fibrotic tissue ingrowth. The system includes an electrode where the porous covering includes a porous communication through the covering to the electrode. The system includes a can that is covered with the porous covering. The system also includes a can with a dielectric coating over the can, and the porous covering allows for a hot can. The system also includes a lead with a dielectric coating over the lead.