Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: A block construction system includes interlocking, self-aligning blocks that can be used to construct structures with mortarless joints. A typical block has a top face that is formed with a raised, substantially flat horizontal portion that extends between a pair of longitudinally aligned rounded edges. Longitudinally aligned horizontal stop surfaces extend from each rounded edge. A bottom face of the block is formed with a pair of longitudinally aligned stop surfaces and a substantially flat portion that is positioned between and recessed from the stop surfaces. For two stacked blocks, the recessed portion of the top block receives and engages the raised portion of the bottom block preventing lateral movement of one block relative to the other. To interlock adjacent blocks on a common course, one end face of each block is formed with a vertically aligned tongue and the other end face is formed with a corresponding groove.

Abstract: A block construction system includes interlocking, self-aligning blocks that can be used to construct structures with mortarless joints. A typical block has a top face that is formed with a raised, substantially flat horizontal portion that extends between a pair of longitudinally aligned rounded edges. Longitudinally aligned horizontal stop surfaces extend from each rounded edge. A bottom face of the block is formed with a pair of longitudinally aligned stop surfaces and a substantially flat portion that is positioned between and recessed from the stop surfaces. For two stacked blocks, the recessed portion of the top block receives and engages the raised portion of the bottom block preventing lateral movement of one block relative to the other. To interlock adjacent blocks on a common course, one end face of each block is formed with a vertically aligned tongue and the other end face is formed with a corresponding groove.